Duc-Hiep Bach
University of Texas MD Anderson Cancer Center
Drug resistanceCancermicroRNAChemistryTumor microenvironmentLung cancerMetastasisTumor progressionEpidermal growth factor receptorAngiogenesisGefitinibBone morphogenetic proteinCancer researchCarcinogenesisSignal transductionComputational biologyMedicinePI3K/AKT/mTOR pathwayBiologyCancer cell
21Publications
13H-index
606Citations
Publications 20
Newest
#1Kyunghee Noh (University of Texas MD Anderson Cancer Center)H-Index: 5
#2Duc-Hiep Bach (University of Texas MD Anderson Cancer Center)H-Index: 13
Last. Anil K. Sood (University of Texas MD Anderson Cancer Center)H-Index: 107
view all 15 authors...
Paxillin (PXN), a key component of the focal adhesion complex, has been associated with cancer progression, but the underlying mechanisms are poorly understood. The purpose of this study was to elucidate mechanisms by which PXN affects cancer growth and progression, which we addressed using cancer patient data, cell lines, and orthotopic mouse models. We demonstrated a previously unrecognized mechanism whereby nuclear PXN enhances angiogenesis by transcriptionally regulating SRC expression. SRC,...
3 CitationsSource
#1Thi-Thu-Trang Luu (SNU: Seoul National University)H-Index: 5
#2Duc-Hiep Bach (SNU: Seoul National University)H-Index: 13
Last. Sang Kook Lee (SNU: Seoul National University)H-Index: 46
view all 6 authors...
BACKGROUND/AIM: The resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs), such as gefitinib or erlotinib, is considered a major challenge in the treatment of patients with non-small cell lung cancer (NSCLC). Herein, we identified the critical roles of anterior gradient 2 (AGR2) in gefitinib (Gef) resistance of mutant NSCLC cells. MATERIALS AND METHODS: Using datasets from a pair of NSCLC-sensitive and NSCLC-resistant cells, immunoblotting, immunofluorescence and ...
1 CitationsSource
#1Duc-Hiep Bach (University of Texas MD Anderson Cancer Center)H-Index: 13
#2Wei ZhangH-Index: 103
Last. Anil K. Sood (University of Texas MD Anderson Cancer Center)H-Index: 107
view all 3 authors...
Chromosomal instability (CIN) is one of the major forms of genomic instability in various human cancers and is recognized as a common hallmark of tumorigenesis and heterogeneity. However, some malignant tumors show a paucity of chromosomal alterations, suggesting that tumor progression and evolution can occur in the absence of CIN. It is unclear whether CIN is stable between precursor lesions, primary tumor, and metastases or if it evolves during these steps. In this review, we describe the infl...
9 CitationsSource
#1Duc-Hiep Bach (SNU: Seoul National University)H-Index: 13
#2Sang Kook Lee (SNU: Seoul National University)H-Index: 46
: Cancer chemotherapies or antitumor agents mainly remain the backbone of current treatment based on killing the rapidly dividing cancer cell such as tylophora alkaloids and their analogues which have also demonstrated anticancer potential through diverse biological pathways including regulation of the immune system. The introduction of durable clinically effective monoclonal antibodies, however, unmasked a new era of cancer immunotherapies. Therefore, the understanding of cancer pathogenesis wi...
9 CitationsSource
#1Ji Yun LeeH-Index: 3
#2Thi-Thu-Trang LuuH-Index: 5
Last. Sang Kook LeeH-Index: 46
view all 6 authors...
Source
#1Duc-Hiep Bach (SNU: Seoul National University)H-Index: 13
#2Sang Kook Lee (SNU: Seoul National University)H-Index: 46
Last. Anil K. Sood (University of Texas MD Anderson Cancer Center)H-Index: 107
view all 3 authors...
Circular RNAs (circRNAs) are a class of single-stranded closed RNA molecules that are formed by precursor mRNA back-splicing or skipping events of thousands of genes in eukaryotes as covalently closed continuous loops. High-throughput sequencing and bioinformatics approaches have uncovered the broad expression of circRNAs across species. Their high stability, abundance, and evolutionary conservation among species points to their distinct properties and diverse cellular functions as efficient mic...
128 CitationsSource
#1Yanhua Fan (SNU: Seoul National University)H-Index: 5
#2Huaiwei Ding (SPU: Shenyang Pharmaceutical University)H-Index: 1
Last. Sang Kook Lee (SNU: Seoul National University)H-Index: 46
view all 7 authors...
Aberrant activation of hepatocyte growth factor (HGF)/c-Met signaling pathway caused by gene amplification or mutation plays an important role in tumorigenesis. Therefore, c-Met is considered as an attractive target for cancer therapy and c-Met inhibitors have been developed with great interests. However, cancers treated with c-Met inhibitors inevitably develop resistance commonly caused by the activation of PI3K/Akt signal transduction pathway. Therefore, the combination of c-Met and PI3Kα inhi...
7 CitationsSource
#1Donghwa Kim (SNU: Seoul National University)H-Index: 8
#2Duc-Hiep Bach (SNU: Seoul National University)H-Index: 13
Last. Sang Kook Lee (SNU: Seoul National University)H-Index: 46
view all 7 authors...
Acquired resistance to epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) has been a major obstacle in the treatment of non-small cell lung cancer (NSCLC) patients. AXL has been reported to mediate EGFR-TKIs. Recently, third generation EGFR-TKI osimertinib has been approved and yet its acquired resistance mechanism is not clearly understood. We found that AXL is involved in both gefitinib and osimertinib resistance using in vitro and in vivo model. In addition, AXL overexpre...
21 CitationsSource
#1Phung Thanh Huong (Hanoi University)H-Index: 3
#2Lap Thi Nguyen (Hanoi University)H-Index: 2
Last. Duc-Hiep Bach (SNU: Seoul National University)H-Index: 13
view all 5 authors...
Besides the critical functions in hemostasis, thrombosis and the wounding process, platelets have been increasingly identified as active players in various processes in tumorigenesis, including angiogenesis and metastasis. Once activated, platelets can release bioactive contents such as lipids, microRNAs, and growth factors into the bloodstream, subsequently enhancing the platelet–cancer interaction and stimulating cancer metastasis and angiogenesis. The mechanisms of treatment failure of chemot...
41 CitationsSource
#1Duc-Hiep Bach (SNU: Seoul National University)H-Index: 13
#2Nguyen Phuoc Long (SNU: Seoul National University)H-Index: 12
Last. Sang Kook Lee (SNU: Seoul National University)H-Index: 46
view all 6 authors...
Forkhead box (FOX) proteins are multifaceted transcription factors that are significantly implicated in cancer, with various critical roles in biological processes. Herein, we provide an overview of several key members of the FOXA, FOXC, FOXM1, FOXO and FOXP subfamilies. Important pathophysiological processes of FOX transcription factors at multiple levels in a context-dependent manner are discussed. We also specifically summarize some major aspects of FOX transcription factors in association wi...
24 CitationsSource