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#1Kevin Tong (RU: Rutgers University)H-Index: 4
#2Om A. Kothari (RU: Rutgers University)H-Index: 1
Last. Jinchuan Xing (RU: Rutgers University)H-Index: 50
view all 13 authors...
BRAF-driven colorectal cancer is among the poorest prognosis subtypes of colon cancer. Previous studies suggest that BRAF-mutant serrated cancers frequently exhibit Microsatellite Instability (MSI) and elevated levels of WNT signaling. The loss of tumor-suppressor Smad4 in oncogenic BRAF-V600E mouse models promotes rapid serrated tumor development and progression, and SMAD4 mutations co-occur in human patient tumors with BRAF-V600E mutations. This study assesses the role of SMAD4 in early-stage ...
#1M Kathryn Leonard (UMB: University of Maryland, Baltimore)H-Index: 4
#2Gemma S Puts (UMB: University of Maryland, Baltimore)H-Index: 2
Last. Marian Novak (UMB: University of Maryland, Baltimore)H-Index: 12
view all 25 authors...
Hepatocyte growth factor-overexpressing mice that harbor a deletion of the Ink4a/p16 locus (HP mice) form melanomas with low metastatic potential in response to UV irradiation. Here we report that these tumors become highly metastatic following hemizygous deletion of the Nme1 and Nme2 metastasis suppressor genes (HPN mice). Whole-genome sequencing of melanomas from HPN mice revealed a striking increase in lung metastatic activity that is associated with missense mutations in eight signature gene...
#1Pengxiang Qiu (UM: University of Macau)H-Index: 1
#2Weilong Hou (UM: University of Macau)H-Index: 1
Last. Samson Sek Man Su (UM: University of Macau)
view all 15 authors...
Sirtuin-1 (SIRT1) is involved in various metabolic pathways, including fatty acid synthesis and gluconeogenesis in the liver. However, its role in initiation and progression of liver cancer remains unclear. Studying Sirt1 liver-specific knockout (LKO) mice in combination with diethylnitrosamine (DEN) treatment, we demonstrated that loss of Sirt1 rendered mice resistant to DEN-induced hepatocellular carcinoma (HCC) development. RNA-seq revealed that livers from LKO mice exhibited an enrichment in...
#1Joanne Lundy (Monash University, Clayton campus)
#2Linden J. Gearing (Monash University, Clayton campus)H-Index: 3
Last. Paul J. Hertzog (Monash University, Clayton campus)H-Index: 76
view all 12 authors...
Pancreatic ductal adenocarcinoma (PDAC) has an extremely poor prognosis, and is plagued by a paucity of targeted treatment options and tumour resistance to chemotherapeutics. The causal link between chronic inflammation and PDAC suggests that molecular regulators of the immune system promote disease pathogenesis and/or therapeutic resistance, yet their identity is unclear. Here, we couple endoscopic ultrasound-guided fine-needle aspiration, which captures tumour biopsies from all stages, with wh...
#1Arnold J. Levine (IAS: Institute for Advanced Study)H-Index: 152
The p53 protein is a transcription factor that prevents tumors from developing. In spontaneous and inherited cancers there are many different missense mutations in the DNA binding domain of the TP53 gene that contributes to tumor formation. These mutations produce a wide distribution in the transcriptional capabilities of the mutant p53 proteins with over four logs differences in the efficiencies of forming cancers in many diverse tissue types. These inherited and spontaneous TP53 mutations prod...
#1Guang Yang (SJTU: Shanghai Jiao Tong University)H-Index: 1
#2Ling Huang (SJTU: Shanghai Jiao Tong University)
Last. Shuchun Li (SJTU: Shanghai Jiao Tong University)H-Index: 1
view all 13 authors...
N-myc downstream-regulated gene 1 (NDRG1) is a key regulator that interacts with many classic tumor signaling pathways, including some molecules downstream of the epidermal growth factor receptor (EGFR). However, whether NDRG1 is involved in the mechanism of resistance to cetuximab (CTX), the first monoclonal antibody targeting the EGFR has not been reported. Here, we found that NDRG1 enhanced the sensitivity of CTX in colorectal cancer (CRC) cell lines. Afterwards, we determined the underlying ...
#1Bo Cen (MUSC: Medical University of South Carolina)H-Index: 8
#2Jie Wei (MUSC: Medical University of South Carolina)H-Index: 3
Last. Raymond N. DuBois (MUSC: Medical University of South Carolina)H-Index: 4
view all 6 authors...
PD-L1 expression is elevated in various human cancers, including colorectal cancer. High levels of PD-L1 expressed on tumor epithelial cells are one of the potential mechanisms by which tumor cells become resistant to immune attack. However, PD-L1 regulation in tumor cells is not fully understood. Here we demonstrate that mutations in the adenomatous polyposis coli (APC) gene lead to colonic epithelial cell resistance to CD8+ T cell cytotoxicity by induction of PD-L1 expression. Mechanistically,...
#1Jun Sun (UM: University of Miami)H-Index: 10
#2Gabriel Gaidosh (UM: University of Miami)H-Index: 8
Last. Stephen D. Nimer (UM: University of Miami)H-Index: 36
view all 11 authors...
The activity of Rho family GTPase protein, RAC1, which plays important normal physiological functions, is dysregulated in multiple cancers. RAC1 is expressed in both estrogen receptor alpha (ER)-positive and ER-negative breast cancer (BC) cells. However, ER-positive BC is more sensitive to RAC1 inhibition. We have determined that reducing RAC1 activity, using siRNA or EHT 1864 (a small molecule Rac inhibitor), leads to rapid ER protein degradation. RAC1 interacts with ER within the ER complex an...
#1Haoran Li (Fudan University)H-Index: 6
#2Zihao QiH-Index: 1
Last. Ziliang Wang (Fudan University)H-Index: 14
view all 10 authors...
Fructose-1,6-bisphosphatase (FBP1) is a rate-limiting enzyme in gluconeogenesis and an important tumor suppressor in human malignancies. Here, we aimed to investigate the expression profile of FBP1 in ovarian cancer, the molecular mechanisms that regulate FBP1 expression and to examine how the FBP1 regulatory axis contributes to tumorigenesis and progression in ovarian cancer. We showed that FBP1 expression was significantly decreased in ovarian cancer tissues compared with normal ovarian tissue...
#1Luigi Magrin (University of Palermo)
#2Daniele Fanale (University of Palermo)H-Index: 22
Last. Viviana Bazan (University of Palermo)H-Index: 35
view all 10 authors...
POLE, POLD1, and NTHL1 are involved in DNA replication and have recently been recognized as hereditary cancer-predisposing genes, because their alterations are associated with colorectal cancer and other tumors. POLE/POLD1-associated syndrome shows an autosomal dominant inheritance, whereas NTHL1-associated syndrome follows an autosomal recessive pattern. Although the prevalence of germline monoallelic POLE/POLD1 and biallelic NTHL1 pathogenic variants is low, they determine different phenotypes...
Top fields of study
Molecular biology
Cancer research
Cell biology