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#1Yi Wang (WMU: Wenzhou Medical College)H-Index: 58
#2Haitao Yu (First Affiliated Hospital of Wenzhou Medical University)H-Index: 1
Last. Gang Chen (First Affiliated Hospital of Wenzhou Medical University)H-Index: 15
view all 13 authors...
Cholangiocarcinoma (CCA) is aggressive and has poor clinical outcomes because of typically delayed diagnosis and a lack of effective non-surgical therapeutic options. Recent studies have shown that plasmalemma vesicle-associated protein (PLVAP) is related to angiogenesis in various tumors, and in vivo PLVAP targeting therapy has been proven effective against hepatocellular carcinoma and pancreatic cancer. The goal of this study was to determine the potential therapeutic utility of targeting PLVA...
#1Yuning Liao (Guangzhou Medical University)H-Index: 16
#2Yuan Liu (Guangzhou Medical University)H-Index: 7
Last. Hongbiao Huang (Guangzhou Medical University)H-Index: 24
view all 15 authors...
Prostate cancer (PC) is the second most common cancer with limited treatment option in males. Although the reactivation of embryonic signals in adult cells is one of the characteristics of cancer, the underlying protein degradation mechanism remains elusive. Here, we show that the molecular chaperone GRP75 is a key player in PC cells by maintaining the protein stability of SIX1, a transcription factor for embryonic development. Mechanistically, GRP75 provides a platform to recruit the deubiquiti...
#1Jacqueline Nathansen (HZDR: Helmholtz-Zentrum Dresden-Rossendorf)H-Index: 1
#2Vasyl Lukiyanchuk (HZDR: Helmholtz-Zentrum Dresden-Rossendorf)H-Index: 1
Last. Anna Dubrovska (HZDR: Helmholtz-Zentrum Dresden-Rossendorf)H-Index: 32
view all 11 authors...
Head and neck squamous cell carcinoma (HNSCC) is often being diagnosed at an advanced stage, conferring a poor prognosis. The probability of local tumor control after radiotherapy depends on the eradication of cancer stem cells (CSCs) with activated DNA repair. This study provides evidence that the CSC-related transcription factor Oct4 contributes to HNSCC radioresistance by regulating DNA damage response and the CSC phenotype. Knockdown of Oct4 A isoform reduced self-renewal capacity in HNSCC a...
#1Quanyou Wu (Peking Union Medical College)
#2Yuan Zhang (XMU: Xinjiang Medical University)H-Index: 1
Last. Kaitai Zhang (Peking Union Medical College)
view all 7 authors...
Aberrant alternative splicing events (AASEs) are key biological processes for tumorigenesis and the rationale for designing splice-switching oligonucleotides (SSOs). However, the landscape of AASEs in esophageal squamous cell carcinoma (ESCC) remains unclear, which undermines the development of SSOs for ESCC. Here, we profiled AASEs based on 125 pairs of RNA-seq libraries. We identified 14,710 AASEs in ESCC, most of which (92.67%) affected coding genes. The first exon of transcripts was frequent...
#1Punit Saraon (OICR: Ontario Institute for Cancer Research)
#2Shivanthy Pathmanathan (U of T: University of Toronto)H-Index: 1
Last. Igor Stagljar (U of T: University of Toronto)H-Index: 55
view all 6 authors...
Receptor tyrosine kinases (RTKs) are transmembrane receptors of great clinical interest due to their role in disease, notably cancer. Since their discovery, several mechanisms of RTK dysregulation have been identified, resulting in multiple cancer types displaying 'oncogenic addiction' to RTKs. As a result, RTKs have represented a major class for targeted therapeutics over the past two decades, with numerous small molecule-based tyrosine kinase inhibitor (TKI) therapeutics having been developed ...
#1Craig S Thomson (UC: University of Cincinnati)H-Index: 1
#2Jay Pundavela (Cincinnati Children's Hospital Medical Center)H-Index: 8
Last. Nancy Ratner (Cincinnati Children's Hospital Medical Center)H-Index: 66
view all 9 authors...
Malignant peripheral nerve sheath tumors (MPNST) are aggressive soft-tissue sarcomas that cause significant mortality in adults with neurofibromatosis type 1. We compared gene expression of growth factors in normal human nerves to MPNST and normal human Schwann cells to MPNST cell lines. We identified WNT5A as the most significantly upregulated ligand-coding gene and verified its protein expression in MPNST cell lines and tumors. In many contexts WNT5A acts as an oncogene. However, inhibiting WN...
2 CitationsSource
#1Xin Yang (Soochow University (Suzhou))H-Index: 2
#2Yan Chen (Soochow University (Suzhou))H-Index: 7
Last. Mei Ji (Soochow University (Suzhou))H-Index: 16
view all 12 authors...
Lung cancer is the leading cause of cancer-related death worldwide. Glypican-5 (GPC5) is a member of heparan sulfate proteoglycans, and its biological importance in initiation and progression of lung cancer remains controversial. In the present study, we revealed that GPC5 transcriptionally enhanced the expression of CTDSP1 (miR-26b host gene) via AhR-ARNT pathway, and such up-regulation of CTDSP1 intracellularly contributed to the inhibited proliferation of lung cancer cells. Moreover, exosomes...
#1Mengqin Shen (SJTU: Shanghai Jiao Tong University)H-Index: 4
#2Ruixue Zhang (SJTU: Shanghai Jiao Tong University)H-Index: 1
Last. Jianjun Liu (SJTU: Shanghai Jiao Tong University)H-Index: 23
view all 8 authors...
Hypoxia and related oxidative stress are closely related to the development and treatment of hepatocellular carcinoma (HCC). However, the mechanism mediated by hypoxia in HCC has not yet been elucidated. Here, we found multifunction scaffold protein p54nrb/NONO exerted pleiotropic effects to regulate hypoxia transcription signals, thereby enhancing the progression of liver cancer. Extensive analysis of clinical data demonstrated that NONO was significantly upregulated and represented as a poor p...
#1Yina Qiao (MOE: Chinese Ministry of Education)H-Index: 4
#2Ting Jin (MOE: Chinese Ministry of Education)H-Index: 2
Last. Yixuan Hou (CQMU: Chongqing Medical University)H-Index: 15
view all 13 authors...
Invasion and metastasis are the leading causes of death in patients with breast cancer (BC), and epithelial-mesenchymal transformation (EMT) plays an essential role in this process. Here, we found that Lnc-408, a novel long noncoding RNA (lncRNA), is significantly upregulated in BC cells undergoing EMT and in BC tumor with lymphatic metastases compared with those without lymphatic metastases. Lnc-408 can enhance BC invasion and metastasis by regulating the expression of LIMK1. Mechanistically, L...
#1Jun You (Ha Tai: Xiamen University)
#2Jiayi Li (Fujian Medical University)H-Index: 1
Last. Qiyuan Li (Ha Tai: Xiamen University)
view all 9 authors...
Emerging evidences suggest that long noncoding RNA (lncRNA) plays a vital role in tumorigenesis and cancer progression. Here, the aim of this study is to investigate the biological function of long intervening noncoding RNA Linc00284 in colorectal cancer (CRC). The expression levels of Linc00284, miR-27a and c-Met were evaluated by qPCR and/or Western blotting. Immunohistochemistry was used to detect the expression of Ki67 and Phh3 in tumor tissues. The interaction between Linc00284, miR-27a and...
Top fields of study
Molecular biology
Cancer research
Cell biology