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#1Ling Yin (Sun Yat-sen University)
#2Yongji Zeng (Eppley Institute for Research in Cancer and Allied Diseases)H-Index: 7
Last. Jixin Dong (Eppley Institute for Research in Cancer and Allied Diseases)H-Index: 27
view all 10 authors...
Anti-tubulin agents, such as paclitaxel, have been used extensively for treatment of several types of cancer, including ovarian, lung, breast, and pancreatic cancers. Despite their wide use in cancer treatment, however, patient response is highly variable and drug resistance remains a major clinical issue. Protein kinase RNA-activated (PKR) plays a critical role in immune response to viral infection. We identified PKR as a phospho-protein in response to anti-tubulin agents and this phosphorylati...
#1Ya Kong (CAS: Chinese Academy of Sciences)H-Index: 1
#2Yu-Tian Zhang (CAS: Chinese Academy of Sciences)H-Index: 1
Last. Jia Li
view all 8 authors...
Emerging evidence shows the association between nuclear envelope and tumor progression, however, the functional contributions of specific constituents of the nuclear envelope remain largely unclear. We found that the expression level of transmembrane protein 201 (TMEM201), an integral inner nuclear membrane protein of unknown function, was significantly elevated in invasive breast cancer and predicted poor breast cancer prognosis. We showed that TMEM201, as a positive modulator, was both necessa...
#1Yang Chen (WHU: Wuhan University)H-Index: 4
#2H Zhao (WHU: Wuhan University)H-Index: 1
Last. Zheng-Jun Shang (WHU: Wuhan University)H-Index: 18
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Autophagy is an essential catabolic process that orchestrates cellular homeostasis and plays dual roles in tumor promotion and suppression. However, the mechanism by which autophagy affects the self-renewal of cancer stem cells (CSCs) remains unclear. In this study, we investigated whether autophagy activation contributes to CSC properties of head and neck squamous cell carcinoma (HNSCC). The results showed that the autophagy level and CSC properties of HNSCC cells were elevated in response to s...
#1Dawei Song (Karolinska University Hospital)H-Index: 2
#2Sonia Cismas (Karolinska University Hospital)H-Index: 1
Last. Leonard Girnita (Karolinska University Hospital)H-Index: 35
view all 11 authors...
As the p53 tumor suppressor is rarely mutated in conjunctival melanoma (CM), we investigated its activation as a potential therapeutic strategy. Preventing p53/Mdm2 interaction by Nutlin-3, the prototypical Mdm2 antagonist, or via direct siRNA Mdm2 depletion, increased p53 and inhibited viability in CM cell lines. The sensitivity to Nutlin-3 p53 reactivation with concomitant Mdm2 stabilization was higher than that achieved by siRNA, indicative of effects on alternative Mdm2 targets, identified a...
#2Carmen DorneburgH-Index: 4
Last. Christian BeltingerH-Index: 19
view all 7 authors...
CHD5, a tumor suppressor at 1p36, is frequently lost or silenced in poor prognosis neuroblastoma (NB) and many adult cancers. The role of CHD5 in metastasis is unknown. We confirm that low expression of CHD5 is associated with stage 4 NB. Forced expression of CHD5 in NB cell lines with 1p loss inhibited key aspects of the metastatic cascade in vitro: anchorage-independent growth, migration, and invasion. In vivo, formation of bone marrow and liver metastases developing from intravenously injecte...
#1Christina Demetriadou (UCY: University of Cyprus)H-Index: 3
#2Anastasia Raoukka (UCY: University of Cyprus)
Last. Antonis Kirmizis (UCY: University of Cyprus)H-Index: 14
view all 11 authors...
Aberrant function of epigenetic modifiers plays an important role not only in the progression of cancer but also the development of drug resistance. N-alpha-acetyltransferase 40 (NAA40) is a highly specific epigenetic enzyme catalyzing the transfer of an acetyl moiety at the N-terminal end of histones H4 and H2A. Recent studies have illustrated the essential oncogenic role of NAA40 in various cancer types but its role in chemoresistance remains unclear. Here, using transcriptomic followed by met...
#1Seung Un Seo (KMU: Keimyung University)H-Index: 12
#2Seon Min Woo (KMU: Keimyung University)H-Index: 15
Last. Taeg Kyu Kwon (KMU: Keimyung University)H-Index: 72
view all 11 authors...
Cathepsin K is highly expressed in various types of cancers. However, the effect of cathepsin K inhibition in cancer cells is not well characterized. Here, cathepsin K inhibitor (odanacatib; ODN) and knockdown of cathepsin K (siRNA) enhanced oxaliplatin-induced apoptosis in multiple cancer cells through Bax upregulation. Bax knockdown significantly inhibited the combined ODN and oxaliplatin treatment-induced apoptotic cell death. Stabilization of p53 by ODN played a critical role in upregulating...
#1Yonghwan Shin (USC: University of Southern California)H-Index: 9
#2Sungmin Kim (USC: University of Southern California)
Last. Woojin An (USC: University of Southern California)H-Index: 32
view all 5 authors...
Melanoma is a type of skin cancer that develops in pigment-producing melanocytes and often spreads to other parts of the body. Aberrant gene expression has been considered as a crucial step for increasing the risk of melanomagenesis, but how chromatin reorganization contributes to this pathogenic process is still not well understood. Here we report that matrix metalloproteinase 9 (MMP-9) localizes to the nucleus of melanoma cells and potentiates gene expression by proteolytically clipping the hi...
#1Chen Chen Jiang (UoN: University of Newcastle Australia)H-Index: 31
#2Mark Marsland (UoN: University of Newcastle Australia)H-Index: 1
Last. Hubert Hondermarck (UoN: University of Newcastle Australia)H-Index: 45
view all 12 authors...
Nerve infiltration in the tumor microenvironment is emerging as a promoter of cancer progression that could be targeted in therapies, but the mechanisms initiating tumor innervation remain to be elucidated. Here we report that endoplasmic reticulum (ER) stress in cancer cells is transmitted to neuronal cells, resulting in neurite outgrowth and tumor innervation. In vitro, the induction of ER stress in various human cancer cells resulted in the synthesis and release of the precursor for brain-der...
#1Xin Jin (CSU: Central South University)H-Index: 8
#2Bin Zhang (HUST: Huazhong University of Science and Technology)H-Index: 1
Last. Haixin Yu (HUST: Huazhong University of Science and Technology)
view all 4 authors...
Although tobacco smoking is a risk factor for lung adenocarcinoma (LUAD), the mechanisms by which tobacco smoking induces LUAD development remain elusive. Histone methylation levels in human bronchial epithelial cells have been reported to increase after exposure to cigarettes. In this study, we explored the mechanisms regulating histone methylation in LUAD in response to smoking. We found that the histone H3K9 methylation reader CBX3 was upregulated in current smokers with LUAD, and that CBX3 o...
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