Oncogene
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#1Zeyuan Yu (Lanzhou University)H-Index: 4
#2Xiangyan Jiang (Lanzhou University)H-Index: 2
Last. Zuoyi Jiao (Lanzhou University)H-Index: 1
view all 17 authors...
Dysregulation of the Wnt/β-catenin signaling pathway is critically involved in gastric cancer (GC) progression. However, current Wnt pathway inhibitors being studied in preclinical or clinical settings for other cancers such as colorectal and pancreatic cancers are either too cytotoxic or insufficiently efficacious for GC. Thus, we screened new potent targets from β-catenin destruction complex associated with GC progression from clinical samples, and found that scaffolding protein RACK1 deficien...
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#1Anderly C. ChuehH-Index: 13
#2Gahana Advani (University of Melbourne)H-Index: 1
Last. Heung-Chin Cheng (University of Melbourne)H-Index: 26
view all 22 authors...
Hyperactivation of SRC-family protein kinases (SFKs) contributes to the initiation and progression of human colorectal cancer (CRC). Since oncogenic mutations of SFK genes are rare in human CRC, we investigated if SFK hyperactivation is linked to dysregulation of their upstream inhibitors, C-terminal SRC kinase (CSK) and its homolog CSK-homologous kinase (CHK/MATK). We demonstrate that expression of CHK/MATK but not CSK was significantly downregulated in CRC cell lines and primary tumours compar...
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#1Carolina Mantilla-Rojas (A&M: Texas A&M University)
#2Ming Yu (UNC: University of North Carolina at Chapel Hill)H-Index: 3
Last. David W. ThreadgillH-Index: 55
view all 11 authors...
Although epidermal growth factor receptor (EGFR)-targeted therapies are approved for colorectal cancer (CRC) treatment, only 15% of CRC patients respond to EGFR inhibition. Here, we show that colorectal cancers (CRC) can initiate and grow faster through an EGFR-independent mechanism, irrespective of the presence of EGFR, in two different mouse models using tissue-specific ablation of Egfr. The growth benefit in the absence of EGFR is also independent of Kras status. An EGFR-independent gene expr...
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#1Zeina Nehme (Lebanese University)H-Index: 2
Last. Georges HerbeinH-Index: 31
view all 11 authors...
A growing body of evidence is recognizing human cytomegalovirus (HCMV) as a potential oncogenic virus. We hereby provide the first experimental in vitro evidence for HCMV as a reprogramming vector, through the induction of dedifferentiation of mature human mammary epithelial cells (HMECs), generation of a polyploid giant cancer cell (PGCC) phenotype characterized by sustained growth of blastomere-like cells, in concordance with the acquisition of embryonic stem cells characteristics and epitheli...
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#1Xiaoshuang Wang (Fudan University)
#2Mei Feng (Fudan University)H-Index: 1
Last. Di Zhu (Fudan University)H-Index: 2
view all 18 authors...
Treatment of patients with triple-negative breast cancer (TNBC) has been challenging due to a lack of well-defined molecular targets. The Wnt/β-catenin pathway is known to be activated in many TNBC patients and BCL9 and BCL9L are important transcriptional co-activators of β-catenin, but whether inhibition of BCL9/BCL9L can suppress TNBC growth and the underlying mechanism are not fully understood. Here we demonstrate that the expression of BCL9 and BCL9L is directly correlated with malignancy in...
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#1Wen-Hui Chen (SYSU: Sun Yat-sen University)
#2Muyan Cai (SYSU: Sun Yat-sen University)H-Index: 8
Last. Dan Xie (SYSU: Sun Yat-sen University)H-Index: 52
view all 16 authors...
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#1Jacqueline Bernardino-Sgherri (Université Paris-Saclay)
#2Capucine Siberchicot (Université Paris-Saclay)H-Index: 1
Last. Anne Bravard (Université Paris-Saclay)
view all 11 authors...
In solid cancers, high expression of the cellular prion protein (PrPC) is associated with stemness, invasiveness, and resistance to chemotherapy, but the role of PrPC in tumor response to radiotherapy is unknown. Here, we show that, in neuroblastoma, breast, and colorectal cancer cell lines, PrPC expression is increased after ionizing radiation (IR) and that PrPC deficiency increases radiation sensitivity and decreases radiation-induced radioresistance in tumor cells. In neuroblastoma cells, IR ...
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#1Ahmet Cingoz (Koç University)H-Index: 6
#2Ezgi Ozyerli-Goknar (Koç University)H-Index: 1
Last. Tugba Bagci-Onder (Koç University)H-Index: 10
view all 10 authors...
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces tumor cell-specific apoptosis, making it a prime therapeutic candidate. However, many tumor cells are either innately TRAIL-resistant, or they acquire resistance with adaptive mechanisms that remain poorly understood. In this study, we generated acquired TRAIL resistance models using multiple glioblastoma (GBM) cell lines to assess the molecular alterations in the TRAIL-resistant state. We selected TRAIL-resistant cells thro...
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#1Fu-Chun Huo (Xuzhou Medical College)H-Index: 1
Last. Jie Mou (Xuzhou Medical College)H-Index: 5
view all 6 authors...
N6-methyladenosine (m6A) RNA methylation is profoundly involved in epigenetic regulation, especially for carcinogenesis and tumor progression. Mounting evidence suggests that methyltransferase METTL3 regulates malignant behaviors of gastric cancer (GC). However, the clinical significance and biological implication of SPHK2 and its related m6A modification in GC remain unclear. In this study, quantitative real-time PCR (qRT-PCR), western blot and immunohistochemistry were utilized to detect the e...
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#1Thaidy Moreno (CSIC: Spanish National Research Council)H-Index: 6
#2B Monterde (CSIC: Spanish National Research Council)H-Index: 1
Last. Ignacio Varela (CSIC: Spanish National Research Council)H-Index: 40
view all 20 authors...
The survival rate in lung cancer remains stubbornly low and there is an urgent need for the identification of new therapeutic targets. In the last decade, several members of the SWI/SNF chromatin remodeling complexes have been described altered in different tumor types. Nevertheless, the precise mechanisms of their impact on cancer progression, as well as the application of this knowledge to cancer patient management are largely unknown. In this study, we performed targeted sequencing of a cohor...
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Cancer
Molecular biology
Cancer research
Carcinogenesis
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Cell biology