Helicobacter pylori Related Diseases and Osteoporotic Fractures (Narrative Review)

Published on Oct 12, 2020in Journal of Clinical Medicine3.303
· DOI :10.3390/JCM9103253
Leon Fisher4
Estimated H-index: 4
(Frankston Hospital),
Alexander Fisher12
Estimated H-index: 12
(ANU: Australian National University)
+ 0 AuthorsPaul N. Smith36
Estimated H-index: 36
Sources
Abstract
Osteoporosis (OP) and osteoporotic fractures (OFs) are common multifactorial and heterogenic disorders of increasing incidence. Helicobacter pylori (H.p.) colonizes the stomach approximately in half of the world’s population, causes gastroduodenal diseases and is prevalent in numerous extra-digestive diseases known to be associated with OP/OF. The studies regarding relationship between H.p. infection (HPI) and OP/OFs are inconsistent. The current review summarizes the relevant literature on the potential role of HPI in OP, falls and OFs and highlights the reasons for controversies in the publications. In the first section, after a brief overview of HPI biological features, we analyze the studies evaluating the association of HPI and bone status. The second part includes data on the prevalence of OP/OFs in HPI-induced gastroduodenal diseases (peptic ulcer, chronic/atrophic gastritis and cancer) and the effects of acid-suppressive drugs. In the next section, we discuss the possible contribution of HPI-associated extra-digestive diseases and medications to OP/OF, focusing on conditions affecting both bone homeostasis and predisposing to falls. In the last section, we describe clinical implications of accumulated data on HPI as a co-factor of OP/OF and present a feasible five-step algorithm for OP/OF risk assessment and management in regard to HPI, emphasizing the importance of an integrative (but differentiated) holistic approach. Increased awareness about the consequences of HPI linked to OP/OF can aid early detection and management. Further research on the HPI–OP/OF relationship is needed to close current knowledge gaps and improve clinical management of both OP/OF and HPI-related disorders.
References738
Newest
#1Jyotirmaya Behera (University of Louisville)H-Index: 11
#2Jessica Ison (University of Louisville)H-Index: 1
Last. Neetu Tyagi (University of Louisville)H-Index: 52
view all 4 authors...
Abstract The gut microbiota (GM) is referred to as the second gene pool of the human body and a commensal, symbiotic, and pathogenic microorganism living in our intestines. The knowledge of the complex interaction between intestinal microbiota and health outcomes is a novel and rapidly expanding the field. Earlier studies have reported that the microbial communities affect the cellular responses and shape many aspects of physiology and pathophysiology within the body, including muscle and bone m...
18 CitationsSource
#1Joo-Hyun Park (KU: Korea University)H-Index: 6
#2Yun-Mi Song (SMC: Samsung Medical Center)H-Index: 26
Last. Han Ka (Soongsil University)
view all 4 authors...
Abstract The influence of proton pump inhibitors (PPIs) on the risk of osteoporotic fractures remains to be elucidated, especially in the Asian population. This study evaluated the risk of osteoporotic fractures in elderly female Korean PPI users compared to histamine-2 receptor antagonist (H2RA) users, as well as the relationship between fractures and the duration, dose, and pattern of use of PPI. We screened a nationwide cohort of elderly Korean women who underwent bone mineral density measure...
2 CitationsSource
#1Eva Doorakkers (Karolinska University Hospital)H-Index: 4
#2Jesper Lagergren ('KCL': King's College London)H-Index: 77
Last. Nele Brusselaers (KI: Karolinska Institutet)H-Index: 28
view all 5 authors...
BACKGROUND: Helicobacter pylori (H. pylori) is associated with lower risks of Barrett's esophagus and esophageal adenocarcinoma, but whether H. pylori eradication increases the risk of these conditions is unknown. This study aimed to test the hypothesis that H. pylori eradication leads to gradually increased risks of Barrett's esophagus and esophageal adenocarcinoma over time, while esophageal squamous cell carcinoma was assessed for comparison reasons. MATERIAL AND METHODS: This Swedish nationw...
8 CitationsSource
#1Meng-Che Wu (CSMU: Chung Shan Medical University)H-Index: 3
#2Jing-Yang Huang (CSMU: Chung Shan Medical University)H-Index: 15
Last. James Cheng-Chung Wei (CSMU: Chung Shan Medical University)H-Index: 28
view all 4 authors...
BACKGROUND: This study aimed to investigate whether early eradication therapy influences systemic lupus erythematosus (SLE) risk in patients with Helicobacter pylori (HP) infection. METHODS: We identified 41,653 patients with HP infection in Taiwan from 2000 to 2013. The patient population was divided into early (within three months) and late (after three months) eradication cohorts. age, sex, co-morbidities and medical visits were matched at a 1:1 ratio. Multiple Cox regression, sensitivity ana...
2 CitationsSource
#1Seyedeh Zahra Bakhti (UMA: University of Mohaghegh Ardabili)H-Index: 5
#2Saeid Latifi-Navid (UMA: University of Mohaghegh Ardabili)H-Index: 14
Last. Reza Safaralizadeh (University of Tabriz)H-Index: 16
view all 3 authors...
Helicobacter pylori is known as an important determinant of preneoplastic lesions or gastric cancer (GC) risk. The bacterial genotypes may determine the clinical outcomes. However, the evidence for these associations has varied between and within continents, and the actual effect of each gene and corresponding allelic variants are still debatable. In recent years, two new models have been proposed to predict the risk of GC; the phylogeographic origin of H. pylori strains and a disrupted co-evolu...
10 CitationsSource
#1Hyerim Park (UTokyo: University of Tokyo)H-Index: 1
#2Hiroki Satoh (UTokyo: University of Tokyo)H-Index: 8
Last. Yasufumi Sawada (UTokyo: University of Tokyo)H-Index: 32
view all 8 authors...
Aim Falls are a significant problem for older people, but are few studies of the risk of falling in residents of nursing homes in Japan. We aimed to investigate the risk factors for falls and the association of medication use and falls in nursing home residents in Japan.
1 CitationsSource
#1Shelly L. Gray (UW: University of Washington)H-Index: 44
#2Zachary A. Marcum (UW: University of Washington)H-Index: 25
Last. Eric B. Larson (UW: University of Washington)H-Index: 67
view all 9 authors...
BACKGROUND: It is well established that individual medications that affect the central nervous system (CNS) increase falls risk in older adults. However, less is known about risks associated with taking multiple CNS-active medications. METHODS: Employing a new user design, we used data from the Adult Changes in Thought study, a prospective cohort of community-dwelling people aged 65 and older without dementia. We created a time-varying composite measure of CNS-active medication exposure from ele...
5 CitationsSource
#1Sharri J Mortensen (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 5
#2Amin Mohamadi (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 9
Last. Ara Nazarian (Yerevan State Medical University)H-Index: 35
view all 7 authors...
Fragility hip fractures and their associated morbidity and mortality pose a global healthcare problem. Several pharmaceutical products have been postulated to alter bone architecture and contribute to fragility hip fractures. We searched four electronic databases from inception to September 2017. Inclusion criteria were the following: (1) adult patients with fragility hip fractures, (2) full text in English, (3) minimum one-year follow-up, and (4) reporting of at least one risk factor. To minimi...
5 CitationsSource
#1Xiaozhou Zhang (UZH: University of Zurich)H-Index: 5
#2Isabelle C. Arnold (UZH: University of Zurich)H-Index: 19
Last. Anne Müller (UZH: University of Zurich)H-Index: 38
view all 3 authors...
The gastric bacterium Helicobacter pylori efficiently evades innate immune detection and persistently colonizes its human host. Understanding the genetic determinants that H. pylori uses to establish and maintain persistence, along with their cellular targets, is key to our understanding of the pathogenesis of this extraordinarily successful bacterial colonizer of the human stomach. This review highlights recent advances in elucidating innate immune recognition of H. pylori, its interactions wit...
7 CitationsSource
#1Hengting Chen (Tianjin Medical University)H-Index: 4
#1Hengting Chen (Tianjin Medical University)H-Index: 1
Last. Xinlong MaH-Index: 1
view all 5 authors...
ABSTRACT Introduction The association between sarcopenia and risk of fracture remained controversial. This systematic review and meta-analysis was conducted to evaluate the association between sarcopenia and fracture incidence in the middle-aged and elderly people. Materials and Methods Web of Science, PubMed, EMBASE, and the Cochrane Library were searched. Weighted averages were reported as hazard risk (HR) values with 95% confidence interval (CI). Statistical heterogeneity scores were assessed...
7 CitationsSource
Cited By2
Newest
#1Hammad UllahH-Index: 10
#2Alessandro Di MinnoH-Index: 20
Last. Maria DagliaH-Index: 64
view all 7 authors...
Helicobacter pylori (H. pylori) infections affect almost half of the world’s population, with gradually increasing incidence in developed countries. Eradication of H. pylori may provide significant benefits to the affected individual by healing a number of gastrointestinal and extra-digestive disorders. But due to increased microbial resistance and lack of patient adherence to the therapy, the eradication rate of H. pylori is below 80% with current pharmacological therapies. The usage of botanic...
Source
Background Studies suggested Banxia Xiexin Decoction is effective in the treatment of helicobacter pylori (HP) positive peptic ulcer. The present meta-analysis aimed at evaluating the efficacy and safety of Banxia Xiexin decoction in the treatment HP positive peptic ulcer. Methods We will search PubMed, Web of Science, Cochrane Library, and Chinese biomedical databases from their inceptions to the November 30th, 2020. Two authors will independently carry out searching literature records, scannin...
Source