The overlap between Alzheimer's disease and epilepsy uncovered by transcriptome sequencing

Dear editor, We conducted a combinated analysis of the hippocampal transcriptome of Alzheimer's disease (AD) and epilepsy mice for the first time. Our study found that TNF-α-HIF-1-NF-κB pathway axis and circadian rhythm pathway are involved in the pathogenesis of AD and epilepsy. Most importantly, FZD7 is remarkable upregulated in the hippocampus of APP/PS1 mice and the temporal cortex of humans, which suggests that FZD7 maybe an important...