Qingchun Zhao
Shenyang Pharmaceutical University
Internal medicineNotch signaling pathwayChemistryApoptosisIn vitroIn vivoNeuroprotectionOxidative stressAntioxidantHepatocellular carcinomaMetastasisBrown adipose tissueCancer researchBiochemistryMedicineProtein kinase BPI3K/AKT/mTOR pathwayBiologyMeta-analysisPharmacology
49Publications
13H-index
584Citations
Publications 49
Newest
#1Xin Liu (SPU: Shenyang Pharmaceutical University)
#2Ya-ping Gao (SPU: Shenyang Pharmaceutical University)
Last. Qingchun Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 13
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Abstract null null Ethnopharmacological relevance null Cinnamomum cassia Presl (Rougui) has character of xin、gan、wen, belongs to Jing of heart、lung、bladder, and has the effect of dispersing cold and relieving pain. It is widely used to resolve the exterior and dissipate cold in Treatise on Febrile Diseases (Shang Han Lun), such as Chaihu Guizhi Ganjiang Tang and Guizhi Renshen Tang. Both these two prescriptions contain Cinnamomum cassia Presl and Zingiber officinale Rosc (Ganjiang). Rougui-Ganji...
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#1S. Lian (SPU: Shenyang Pharmaceutical University)
#2Xue Zhang (SPU: Shenyang Pharmaceutical University)H-Index: 9
Last. Qingchun Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 13
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BACKGROUND Hand-foot syndrome (HFS) is a common systemic skin toxicity syndrome caused by chemotherapy agents. However, there is no uniform clinical treatment for HFS. It is reported that pyridoxine (vitamin B6) can be used to prevent HFS, but the evidence is insufficient. AIM To determine whether pyridoxine can be used to prevent HFS caused by chemotherapy agents. METHODS Literature database searches were performed on PubMed, Web of Science, Embase, Cochrane Library and China National Knowledge...
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Abstract null null Alzheimer’s disease (AD) is a chronic and progressive neurodegenerative disease, characterized by irreversible cognitive impairment, memory loss and behavioral disturbances, ultimately leading to death. Glycogen synthase kinase 3β (GSK-3β) and dual-specificity tyrosine phosphorylation regulated kinase1A (DYRK1A) have gained a lot of attention for its role in tau pathology. To search for potential dual GSK-3β/DYRK1A inhibitors, we focused on harmine, a natural β-carboline alkal...
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#1Hui Jia (SPU: Shenyang Pharmaceutical University)
#2Mingyue Liu (SPU: Shenyang Pharmaceutical University)H-Index: 1
Last. Jincai Lu (SPU: Shenyang Pharmaceutical University)H-Index: 14
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Abstract Breast cancer (BC) occurrence and development tremendously affect female health. Currently breast cancer targeted drugs are still scarce. Natural products have become the main source of targeted drug for breast cancer due to low toxicity and high efficiency. Cimigenoside, natural compound isolated and purified from Cimicifuga dahurica (Turcz.) Maxim has been suggested to utilize for breast cancer treatment, however the mechanism of action has not been elucidated yet. In this article, th...
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#1Xiang-Li (SPU: Shenyang Pharmaceutical University)H-Index: 1
#2Bo-Xing (SPU: Shenyang Pharmaceutical University)H-Index: 1
Last. Qingchun Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 13
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Abstract Background Cinnamomum cassia (L.) J.Presl (Cinnamon) was known as a kind of hot herb, improved circulation and warmed the body. However, the active components and mechanisms of dispelling cold remain unknown. Methods The effects of several Chinses herbs on thermogenesis were evaluated on body temperature and activation of brown adipose tissue. After confirming the effect, the components of cinnamon were identified using HPLC-Q-TOF/MS and screened with databases. The targets of component...
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#1Yue YangH-Index: 5
#2Huan Gao (SPU: Shenyang Pharmaceutical University)H-Index: 2
Last. Qingchun Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 13
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Abstract Background Arctium lappa L. roots are very popular cultivated vegetables, which possesses various pharmacological activities. Our previous studies have demonstrated that Arctium lappa L. roots exerted protective effects against H2O2, glutamate and N-methyl-D-aspartic acid (NMDA)-induced neuronal injury in vitro. However, whether Arctium lappa L. roots could prevent against cerebral ischemia and the underlying mechanism remain unclear. Purpose The objective of the present study was to in...
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#1Xiang Li (SPU: Shenyang Pharmaceutical University)H-Index: 4
#2Hong-yuan Lu (SPU: Shenyang Pharmaceutical University)H-Index: 5
Last. Qingchun Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 13
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Abstract Ethnopharmacological relevance Cinnamomum cassia (L.) J.Presl (Lauraceae), a widely used traditional Chinese medicine, is well known to exert hot property. It is recorded as dispelling cold drug in ancient Chinese monographs, such as Synopsis of golden chamber published in Han dynasty. According to Chinese Pharmacopoeia (2015), Cinnamomum cassia (L.) J.Presl (Cinnamon) has the functions of dispersing cold, relieving pain, warming meridians and promoting blood circulation. Aim of the stu...
3 CitationsSource
#1Tianshu Ren (SPU: Shenyang Pharmaceutical University)H-Index: 5
#2Shu Wang (SPU: Shenyang Pharmaceutical University)H-Index: 2
Last. Qingchun Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 13
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INTRODUCTION AND OBJECTIVE Guidelines recommend combined doublet backbone chemotherapy based on 5-fluorouracil and oxaliplatin (OX) or irinotecan (IR) as the first-line treatment options for metastatic colorectal cancer. However, it is still unknown which is better when combined with bevacizumab (BEV). This systematic review and meta-analysis were performed to compare BEV-IR with BEV-OX regimens in terms of efficacy and safety. METHODS We searched studies from databases including MEDLINE, EMBASE...
1 CitationsSource
#1Wenwu LiuH-Index: 4
#2Jingda LiH-Index: 2
Last. Qingchun Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 13
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Caffeoylquinic acids (CQAs) are a broad class of secondary metabolites that have been found in edible and medicinal plants from various families. It has been 100 years since the discovery of chloro...
2 CitationsSource
#1Yuting Wu (SPU: Shenyang Pharmaceutical University)H-Index: 2
#2Yingshi Zhang (SPU: Shenyang Pharmaceutical University)H-Index: 12
Last. Qingchun Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 13
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Abstract Hepatocellular carcinoma (HCC) is one of the most common tumors worldwide with high prevalence and lethality. The oncogenic phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) pathway is a classic dysregulated pathway involved in the pathogenesis of HCC. However, the underlying mechanism for how PI3K/AKT/mTOR pathway aberrantly activates HCC has not been entirely elucidated. The recognition of the functional roles of long non-coding RNAs (lncRNAs) in...
5 CitationsSource