Review paper

Natural products as potent inhibitors of hypoxia-inducible factor-1α in cancer therapy

Volume: 18, Issue: 9, Pages: 696 - 703
Published: Sep 1, 2020
Abstract
Hypoxia is a prominent feature of tumors. Hypoxia-inducible factor-1α (HIF-1α), a major subunit of HIF-1, is overexpressed in hypoxic tumor tissues and activates the transcription of many oncogenes. Accumulating evidence has demonstrated that HIF-1α promotes tumor angiogenesis, metastasis, metabolism, and immune evasion. Natural products are an important source of antitumor drugs and numerous studies have highlighted the crucial role of these...
Paper Details
Title
Natural products as potent inhibitors of hypoxia-inducible factor-1α in cancer therapy
Published Date
Sep 1, 2020
Volume
18
Issue
9
Pages
696 - 703
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