Efficacy and safety of sodium RISedronate for glucocorticoid-induced OsTeoporosis with rheumaTOid arthritis (RISOTTO study): A multicentre, double-blind, randomized, placebo-controlled trial.

Published on May 4, 2021in Modern Rheumatology2.113
· DOI :10.1080/14397595.2020.1812835
Yuichiro Fujieda15
Estimated H-index: 15
(Hokkaido University),
Tetsuya Horita23
Estimated H-index: 23
+ 21 AuthorsTatsuya Atsumi65
Estimated H-index: 65
(Hokkaido University)
No evidence has shown the efficacy of Sodium Risedronate (Risedronate) for glucocorticoid-induced osteoporosis (GIO) in patients with Rheumatoid arthritis (RA). The aim of this study was to explore...
#1Shoko Kasai (Tokyo Medical and Dental University)H-Index: 3
#2Ryoko SakaiH-Index: 10
Last. Masayoshi HarigaiH-Index: 4
view all 6 authors...
AbstractObjective: To evaluate the risk of hospitalized infection (HI), cardiovascular disease (CVD), stroke, and fracture in rheumatoid arthritis (RA) patients compared with non-RA patients using ...
7 CitationsSource
#1Mie Torii (Kyoto University)H-Index: 11
#2Motomu Hashimoto (Kyoto University)H-Index: 21
Last. Tsuneyo Mimori (Kyoto University)H-Index: 77
view all 15 authors...
AbstractObjectives: Sarcopenia is characterized by loss of muscle strength and mass, leading to falls and adverse health outcomes. Our aim was to determine the prevalence of sarcopenia in patients with rheumatoid arthritis (RA) and to identify factors associated with sarcopenia in these patients.Methods: A cross-sectional study of 388 consecutive women with RA was conducted, assessing muscle mass and strength, and walking speed. Falls and bone fractures sustained over the prior year were evaluat...
29 CitationsSource
#1Marco Ponzetti (University of L'Aquila)H-Index: 8
#2Nadia Rucci (University of L'Aquila)H-Index: 41
The term osteoimmunology was coined many years ago to describe the research field that deals with the cross-regulation between bone cells and the immune system. As a matter of fact, many factors that are classically considered immune-related, such as interleukins (i.e. IL-6, -11,-17 and -23), tumor necrosis factor (TNF)-α, receptor-activator of nuclear factor kappa B (RANK) and its ligand (RANKL), nuclear factor of activated t-cell, cytoplasmatic-1 (NFATc1) and others have all been found to be c...
36 CitationsSource
#1Naohiro Izawa (UTokyo: University of Tokyo)H-Index: 8
#2Jun Hirose (UTokyo: University of Tokyo)H-Index: 13
Last. Shigeto TohmaH-Index: 29
view all 9 authors...
AbstractObjectives: To investigate the distribution of 25-question Geriatric Locomotive Function Scale (GLFS-25) scores in Japanese rheumatoid arthritis (RA) patients and evaluate relationships with clinical variables.Methods: Among 15,115 patients registered in the NinJa database for fiscal year 2015, 1710 with complete GLFS-25 and disease activity score-28 (DAS28) data were analyzed. Correlations between GLFS-25 score and clinical variables were assessed by Spearman coefficients. Mean GLFS-25 ...
11 CitationsSource
#1Yoshiya Tanaka (University of Occupational and Environmental Health Japan)H-Index: 93
The immune system and bone metabolism influence each other. An imbalance in the immune system, resulting in inflammatory stimuli may induce an imbalance in bone turnover via induction of osteoclast differentiation and inhibition of osteoblast differentiation, leading to various pathological conditions including osteoporosis. T-cell subsets, helper T (Th)1 and Th17, which activate the immune system, induce osteoclasts, whereas regulatory T (Treg) cells, responsible for immunosuppression, inhibit ...
18 CitationsSource
#1Kazuki Yoshida (Harvard University)H-Index: 22
#2Zhi Yu (Johns Hopkins University)H-Index: 14
Last. Daniel H. Solomon (Brigham and Women's Hospital)H-Index: 114
view all 11 authors...
PURPOSE: To examine the effects of analgesics on bone mineral density (BMD), which have not been examined in a longitudinal study with multiple measurements. METHODS: We investigated changes in BMD associated with new use of analgesics in a prospective longitudinal cohort of mid-life women. BMD and medication use were measured annually. We compared BMD among new users of acetaminophen, NSAIDs, and opioids. Adjustment for baseline covariates was conducted through propensity score matching weights...
7 CitationsSource
#1Chadi A. Calarge (BCM: Baylor College of Medicine)H-Index: 18
#2James A. MillsH-Index: 18
Last. Babette S. ZemelH-Index: 82
view all 7 authors...
Objectives: To prospectively examine the independent contribution of major depressive disorder (MDD), generalized anxiety disorder (GAD), and selective serotonin reuptake inhibitors (SSRIs) use to changes in bone metabolism in older adolescents and emerging adults. Methods: Medically-healthy 15 to 20 year-olds who were unmedicated or within one month of starting an SSRI were prospectively followed. Psychiatric functioning and medication treatment were assessed monthly. Every four months, trabecu...
9 CitationsSource
#1A-Li Xue (WMU: Wenzhou Medical College)H-Index: 1
#2Su-Ye WuH-Index: 1
Last. Pu ZhaoH-Index: 2
view all 6 authors...
AbstractBackground:Patients with rheumatoid arthritis (RA) are predisposed to osteoporotic fracture. The present study aims to determine the association between rheumatoid arthritis (RA) and bone fracture risk, and in relation to gender and site-specific fractures.Methods:Studies related to bone fra
31 CitationsSource
#1Lenore Buckley (Yale University)H-Index: 5
#2Gordon H. Guyatt (McMaster University)H-Index: 261
Last. Timothy E. McAlindon (Tufts University)H-Index: 72
view all 21 authors...
Objective To develop recommendations for prevention and treatment of glucocorticoid-induced osteoporosis (GIOP). Methods We conducted a systematic review to synthesize the evidence for the benefits and harms of GIOP prevention and treatment options. The Grading of Recommendations Assessment, Development and Evaluation methodology was used to rate the quality of evidence. We used a group consensus process to determine the final recommendations and grade their strength. The guideline addresses ini...
234 CitationsSource
#1J. A. R. Van Den Hoek (UvA: University of Amsterdam)H-Index: 30
#1J. van den Hoek (UvA: University of Amsterdam)H-Index: 11
Last. Jacqueline M. Dekker (VUmc: VU University Medical Center)H-Index: 90
view all 7 authors...
The aim of this study was to investigate (a) the mortality in a clinical cohort of patients with established rheumatoid arthritis in comparison with the general Dutch population over 15 years, (b) the trend in the mortality ratio during the study period, and (c) causes of death and compare these with the general population. In 1997, a sample of 1222 patients was randomly selected from the register of a large rheumatology outpatient clinic. Their mortality and primary causes of death between 1997...
64 CitationsSource
Cited By1
#1Denise RottaH-Index: 1
#2Angelo FassioH-Index: 12
Last. Giovanni AdamiH-Index: 13
view all 9 authors...
Osteoporosis is a skeletal disorder characterized by impaired bone strength and increased risk of fragility fracture and is among the most relevant comorbidities of rheumatic diseases. The purpose of the present review is to discuss the pathogenesis of local and systemic bone involvement in inflammatory arthritides, especially Rheumatoid Arthritis, Psoriatic Arthritis, and Spondyloarthritides, as well as the effect of anti-rheumatic treatments and anti-osteoporotic medication on bone health and ...
1 CitationsSource