Haploinsufficiency of Cyfip2 Causes Lithium‐Responsive Prefrontal Dysfunction

Objective Genetic variants of the cytoplasmic FMR1‐interacting protein 2 ( CYFIP2 ) encoding an actin‐regulatory protein are associated with brain disorders, including intellectual disability and epilepsy. However, specific in vivo neuronal defects and potential treatments for CYFIP2 ‐associated brain disorders remain largely unknown. Here, we characterized Cyfip2 heterozygous ( Cyfip2 +/− ) mice to understand their neurobehavioral phenotypes...