Nuclear HMGB1 promotes the phagocytic ability of macrophages
Abstract
Phagocytosis is a basic immune response to the invasion of pathogens. High mobility group protein B1 (HMGB1) is a DNA chaperone that is associated with phagocytosis. However, its influence on phagocytosis is debated. In the present study, HMGB1-mutant, HMGB1-overexpressing and HMGB1-silenced RAW264.7 cells were constructed. In addition, HMGB1 conditional knockout mice were constructed to determine the influence of HMGB1 on phagocytosis....
Paper Details
Title
Nuclear HMGB1 promotes the phagocytic ability of macrophages
Published Date
Aug 1, 2020
Journal
Volume
393
Issue
1
Pages
112037 - 112037
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History