Experimental Cell Research
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#1Na Li (Nanjing Medical University)H-Index: 5
#2Ming Yan (Nanjing Medical University)H-Index: 16
Last. Jinhua Yu (Nanjing Medical University)H-Index: 26
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Abstract null null The osteogenic and odontogenic differentiation of dental pulp stem cells (DPSCs) contribute to restoration and regeneration of dental tissue. Previous study indicated that interleukin-37 (IL-37) was an anti-inflammatory factor that affected other pro-inflammatory signals. The aim of this study was to explore the effects of IL-37 on the differentiation of DPSCs. DPSCs were cultured in growth medium with different concentrations of IL-37. We selected the optimal concentration fo...
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#1Xuekai Xiong (City of Hope National Medical Center)H-Index: 3
#2Hongbo Gao (City of Hope National Medical Center)
Last. Ke Ma (City of Hope National Medical Center)H-Index: 15
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Abstract null null Duchene muscular dystrophy leads to progressive muscle structural and functional decline due to chronic degenerative-regenerative cycles. Enhancing the regenerative capacity of dystrophic muscle provides potential therapeutic options. We previously demonstrated that the circadian clock repressor Rev-erbα inhibited myogenesis and Rev-erbα ablation enhanced muscle regeneration. Here we show that Rev-erbα deficiency in the dystrophin-deficient mdx mice promotes regenerative myoge...
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#1Ariege Bizanti (UCF: University of Central Florida)
#2Priyanka Chandrashekar (UCF: University of Central Florida)
Last. Robert L. Steward (UCF: University of Central Florida)H-Index: 9
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Astrocytes are essential to brain homeostasis and their dysfunction can have devastating consequences on human quality of life. Such deleterious effects are generally due in part to changes that occur at the cellular level, which may be biochemical or biomechanical in nature. One biomechanical change that can occur is a change in tissue stiffness. Brain tumors are generally associated with increased brain tissue stiffness, but the impact increased tissue stiffness has on astrocyte biomechanical ...
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#1Daniel Wilhelm Olivier (Stellenbosch University)
#2Etheresia Pretorius (Stellenbosch University)H-Index: 46
Last. Anna-Mart Engelbrecht (Stellenbosch University)H-Index: 24
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Abstract null null The Serum Amyloid A (SAA) family of proteins is associated with various pathological conditions, including cancer. However, their role in cancer is incompletely understood. Here, we investigated the role of SAA1 in cell cycle regulation, apoptosis, survival signaling, metabolism, and metastasis in models of triple-negative breast cancer (TNBC), using RNAi. Our data show that in untransformed epithelial cells (MCF12A), the knockdown of SAA1 induces the expression of cell cycle ...
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Abstract null null We determined the role of time in adipose-derived stem/stromal cell (ASC) response to a model inflammatory environment. ASCs and other mesenchymal stem/stromal cells exhibit immune plasticity. We evaluated the persistence of pro- and anti-inflammatory phenotypes for ASCs exposed to a sustained or pulse inflammatory stimulus. Using qPCR, flow cytometry, and immunocytochemistry, we monitored the temporal expression and up-regulation patterns of a pro-inflammatory gene (caspase 1...
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#1Peng Lu (NCU: Nanchang University)H-Index: 2
#2Yun Xu (NCU: Nanchang University)H-Index: 2
Last. Kai Zhu (NCU: Nanchang University)
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Abstract null null Stresses, such as neurohumoral activation, induced pathological cardiac hypertrophy is the main risk factor for heart failure. The ubiquitin-proteasome system (UPS) plays a key role in maintaining protein homeostasis and cardiac function. However, research on the role and mechanism of deubiquitinating enzymes (DUBs) in cardiac hypertrophy is limited. Here, we observe that the deubiquitinating enzyme ubiquitin-specific protease 12(USP12) is upregulated in Ang II-induced hypertr...
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#1Ning Wang (SJTU: Shanghai Jiao Tong University)H-Index: 2
#2Lu Lu (Zhengzhou University)
Last. Jun Qi (SJTU: Shanghai Jiao Tong University)H-Index: 16
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Abstract null null The bladder undergoes profound structural alterations after bladder outlet obstruction (BOO), characterized by hypertrophy of the bladder wall and accumulation of extracellular matrix (ECM). Transforming growth factor-β (TGF-β) has been found to promote fibrosis of the bladder induced by partial bladder outlet obstruction (pBOO). Activin receptor-like kinase 4 (ALK4) is a downstream receptor of the TGF-β superfamily. However, the role of the ALK4–Smad2/3 pathway in the pathoge...
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#1Shan Yu (Fudan University)H-Index: 8
#2Qian Li (Fudan University)H-Index: 78
Last. Tianshu Liu (Fudan University)H-Index: 17
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Chemotherapy is the preferred clinical treatment for advanced stage gastric cancer (GC) patients, of which efficacy could be markedly impaired due to the development of chemoresistance. Alternatively activated or M2-type tumor associated macrophages (TAMs) are recruited under chemotherapy and are highly implicated in the chemoresistance development, but underlying molecular mechanism for TAM activation is largely unknown. Here, we present that tumor-derived Leukemia inhibitory factor (LIF) induc...
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#1Ahmad Bereimipour (University of Science and Culture)H-Index: 1
#2Hadi Najafi (TMU: Tarbiat Modares University)H-Index: 3
Last. Leila Satarian (Royan Institute)H-Index: 10
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Abstract null null The retina is the innermost part of the eye of most vertebrates and it is essential for vision. The development, maintenance, and function of this laminated structure is tightly regulated by numerous genes. Deficiencies in the expression of these genes as well as deregulation of various molecular mechanisms can cause retinopathies and blindness. MicroRNAs (miRNAs) are one of the most important and effective molecular regulatory mechanisms that underlie the biology of the retin...
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#1Hongzhi Li (Beihua University)
#2Xiang Li (Beihua University)
Last. Binghai Zhao (Beihua University)H-Index: 2
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Non-alcoholic fatty liver disease (NAFLD) and its more advanced stages, Non-alcoholic steatohepatitis and Cirrhosis, are the most common liver diseases in the worldwide, especially in developing countries. NAFLD is distinguished by the accumulation of triglycerides within hepatocytes. An increasing body of evidence suggests that hepatic MicroRNAs play an important role in NAFLD by controlling lipid metabolism, inflammation, and fibrosis. However, the precise causative functions of miRNA in NAFLD...
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