Hui Li
Guangzhou University of Chinese Medicine
Downregulation and upregulationDopaminergicCellMolecular biologyTumor necrosis factor alphaChemistryMesenchymal stem cellImmunologyIn vivoInflammationLipopolysaccharidePaeonolHMGB1Lung injuryTandem mass spectrometryChromatographyViability assaySignal transductionLiquid chromatography–mass spectrometryMedicineSolid phase extractionTranscription factorBiologyCell biologyPharmacology
47Publications
17H-index
1,142Citations
Publications 46
Newest
#1Yongli Gao (CSU: Central South University)H-Index: 74
#2Xing Li (CSU: Central South University)H-Index: 2
Last. Chun-ying Zhang (CSU: Central South University)H-Index: 3
view all 8 authors...
The application of day surgery on thoracic surgery is just started, and the innovation of surgical robots and their application on thoracic surgery bring new opportunities to the development of thoracic day surgery. However, the clinical practice of robot-assisted thoracic day surgery (RTDS) in China still has challenges and disagreements. Based on the experience of domestic experts in the field of RTDS clinical practice, this review discussed several key points of RTDS, including the future dir...
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#1Sen Ye (Guangzhou University of Chinese Medicine)H-Index: 2
#2Jun Zhong (Guangzhou University of Chinese Medicine)H-Index: 1
Last. Dongfeng Chen (Guangzhou University of Chinese Medicine)H-Index: 22
view all 11 authors...
Abstract null null The pathological characteristics of Parkinson's disease (PD) include dopaminergic neuron damage, specifically disorders caused by dopamine synthesis, in vivo. Plastrum testudinis extract (PTE) and its bioactive ingredient ethyl stearate (PubChem CID: 8122) were reported to be correlated with tyrosine hydroxylase (TH), which is a biomarker of dopaminergic neurons. This suggests that PTE and its small-molecule active ingredient ethyl stearate have potential for development as a ...
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#1Jifei Miao (PKU: Peking University)
#2Jun ZhongH-Index: 1
Last. Hui LiH-Index: 17
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Inflammation is a biological process that exists in a large number of diseases. If the magnitude or duration of inflammation becomes uncontrolled, inflammation may cause pathological damage to the host. HMGB1 and NF-κB have been shown to play pivotal roles in inflammation-related diseases. New drugs aimed at inhibiting HMGB1 expression have become a key research focus. In the present study, we showed that paeonol (Pae), the main active component of Paeonia suffruticosa, decreases the expression ...
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#1Jifei Miao (Guangzhou University of Chinese Medicine)H-Index: 5
#2Peng Ye (Guangzhou University of Chinese Medicine)H-Index: 2
Last. Hui Li (Guangzhou University of Chinese Medicine)H-Index: 17
view all 11 authors...
Phagocytosis is a basic immune response to the pathogens invading. Immunosuppression may occur in diseases like sepsis and cancer, and cause a low phagocytic ability of phagocytes. High mobility group protein B1 (HMGB1) is a DNA chaperone which is closely related to the phagocytosis. Nonetheless, its influence on phagocytosis is still controversial. We found that paeonol could inhibit the translocation of HMGB1 from the nucleus to the cytoplasm, it may have an impact on phagocytosis. In the pres...
1 CitationsSource
#1Sen Ye (Guangzhou University of Chinese Medicine)H-Index: 2
#2Jun Zhong (Guangzhou University of Chinese Medicine)H-Index: 1
Last. Caixia Li (Guangzhou University of Chinese Medicine)
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Abstract In this paper, we report the results of treating cells with an effective small molecule, (+)4-cholesten-3-one (PubChem CID: 91477), which can promote neural stem cell(NSC) differentiation into dopaminergic neurons. This study used rat neural stem cells stimulated with two different concentrations (7.8 μM and 78 μM) of (+)4-cholesten-3-one. Cell phenotypic analysis showed that (+)4-cholesten-3-one induced NSC differentiation into dopaminergic neurons, and the level of tyrosine hydroxylas...
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#1Jifei Miao (Guangzhou University of Chinese Medicine)H-Index: 5
#2Sen Ye (Guangzhou University of Chinese Medicine)H-Index: 2
Last. Hui Li (Guangzhou University of Chinese Medicine)H-Index: 2
view all 12 authors...
Abstract Phagocytosis is a basic immune response to the invasion of pathogens. High mobility group protein B1 (HMGB1) is a DNA chaperone that is associated with phagocytosis. However, its influence on phagocytosis is debated. In the present study, HMGB1-mutant, HMGB1-overexpressing and HMGB1-silenced RAW264.7 cells were constructed. In addition, HMGB1 conditional knockout mice were constructed to determine the influence of HMGB1 on phagocytosis. Lipopolysaccharide (LPS) was used to stimulate the...
2 CitationsSource
#1Quan Wen (Guangzhou University of Chinese Medicine)H-Index: 2
#2Jifei Miao (Guangzhou University of Chinese Medicine)H-Index: 5
Last. Hui Li (Guangzhou University of Chinese Medicine)H-Index: 2
view all 14 authors...
Inflammation is a common inducer of numerous severe diseases such as sepsis. The NF-κB signaling pathway plays a key role in the inflammatory process. Its activation promotes the release of pro-inf...
3 CitationsSource
#1Quan Wen (Guangzhou University of Chinese Medicine)H-Index: 2
#2Ngaikeung LauH-Index: 1
Last. Hui Li (Guangzhou University of Chinese Medicine)H-Index: 2
view all 8 authors...
Chrysophanol (Chr) is the main monomer isolated from Rheum rhabarbarum, The aim of this study was to identify the potential in vitro and in in vivo cytoprotective effects of Chr on LPS-triggered acute lung injury (ALI). We used an ALI-murine model and constructed an inflammatory macrophage in vitro cell model to determine the cellular mechanisms involved in Chr-mediated activity.To observe the vital role of HDAC3 (histone deacetylase 3) in abolishing inflammation action, HDAC3 was downregulated ...
1 CitationsSource
#1Liyan Mei (Guangzhou University of Chinese Medicine)H-Index: 5
#2Meihong He (Guangzhou University of Chinese Medicine)H-Index: 1
Last. Hui Li (Guangzhou University of Chinese Medicine)H-Index: 17
view all 17 authors...
Sepsis is a life-threatening disease caused by infection. Inflammation is a key pathogenic process in sepsis. Paeonol, an active ingredient in moutan cortex (a Chinese herb), has many pharmacological activities, such as anti-inflammatory and antitumour actions. Previous studies have indicated that paeonol inhibits the expression of HMGB1 and the transcriptional activity of NF-κB. However, its underlying mechanism is still unknown. In this study, microarray assay and reverse transcription-quantit...
8 CitationsSource
#1Xia Liu (Guida: Guizhou University)H-Index: 2
#2Fei Ai (Guida: Guizhou University)H-Index: 1
Last. Junfeng Guo (Guida: Guizhou University)H-Index: 1
view all 13 authors...
Shenfu injection (SFI), a Chinese herbal medicine with substances extracted from Ginseng Radix et Rhizoma Rubra and Aconiti Lateralis Radix Praeparata, is widely used as an anti-inflammatory reagent to treat endotoxin shock in China. However, the mechanism of SFI in endotoxin shock remains to be illuminated. High mobility group box 1 (HMGB1), a vital inflammatory factor in the late stage of endotoxin shock, may stimulate multiple signalling cascades, including κB (NF-κB), a nuclear transcription...
9 CitationsSource