Transcriptional downregulation of MHC class I and melanoma de- differentiation in resistance to PD-1 inhibition
Abstract
Transcriptomic signatures designed to predict melanoma patient responses to PD-1 blockade have been reported but rarely validated. We now show that intra-patient heterogeneity of tumor responses to PD-1 inhibition limit the predictive performance of these signatures. We reasoned that resistance mechanisms will reflect the tumor microenvironment, and thus we examined PD-1 inhibitor resistance relative to T-cell activity in 94 melanoma tumors...
Paper Details
Title
Transcriptional downregulation of MHC class I and melanoma de- differentiation in resistance to PD-1 inhibition
Published Date
Apr 20, 2020
Journal
Volume
11
Issue
1
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