Matrix Metalloproteinase 9 (MMP9) Inhibitor Prevents Mustard Induced Microvesication and Promotes Cutaneous Wound Healing

Published on Apr 1, 2020in The FASEB Journal4.966
· DOI :10.1096/FASEBJ.2020.34.S1.03367
Yoke-Chen Chang7
Estimated H-index: 7
Selina Muhn1
Estimated H-index: 1
+ 2 AuthorsDonald R. Gerecke18
Estimated H-index: 18
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#1Yoke-Chen Chang (RU: Rutgers University)H-Index: 7
#2Rita A. Hahn (RU: Rutgers University)H-Index: 8
Last. Donald R. Gerecke (RU: Rutgers University)H-Index: 18
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Abstract Sulfur mustard (SM) is a highly toxic blistering agent thought to mediate its action, in part, by activating matrix metalloproteinases (MMPs) in the skin and disrupting components of the basement membrane zone (BMZ). Type IV collagenases (MMP-9) degrade type IV collagen in the skin, a major component of the BMZ at the dermal-epidermal junction. In the present studies, a type IV collagenase inhibitor, N-hydroxy-3-phenyl-2-(4-phenylbenzenesulfonamido) propanamide (BiPS), was tested for it...