PREVALENCE OF MISMATCH REPAIR GENE MUTATIONS IN UVEAL MELANOMA

Purpose: Uveal melanomas are associated with characteristic genetic changes. Germline mutations in mismatch repair (MMR) genes and microsatellite instability have been implicated in the development of numerous malignant neoplasms such as colon and ovarian cancers. The frequency of MMR defects in uveal melanomas has yet to be determined. Methods: Here, we analyzed the frequency of MMR gene mutations in uveal melanoma specimens from the University...