Nicholas J. Protopsaltis
University of California, San Diego
MLH1OphthalmologyCopy-number variationEndothelial stem cellInternal medicineGermline mutationPsychologyRetrospective cohort studyChemistryCohort studyEx vivoTumor microenvironmentCareer developmentMelanomaNeovascularizationCytokineReceiptDiseaseMonosomyMSH3Working ageMEDLINEMicrosatellite instabilityDiabetic retinopathySalaryAngiogenesisExtramuralDiabetic macular edemaIndependent researchInstitutional supportCareer satisfactionGene mutationGeographic regions2019-20 coronavirus outbreakElectronic databaseLate stageIn patientMicrovascular complicationMedian timeDemographic dataCancer researchInterleukin 22Family medicineChemotaxisDiabetes mellitusMedicineCohort
6Publications
2H-index
19Citations
Publications 6
Newest
#1Alexander M. Rusakevich (UC Davis: University of California, Davis)H-Index: 1
#2Nicholas J. Protopsaltis (UCSD: University of California, San Diego)H-Index: 2
Last. Glenn Yiu (UC Davis: University of California, Davis)H-Index: 21
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PURPOSE To characterize clinician-scientists in ophthalmology and identify factors associated with successful research funding, income, and career satisfaction. DESIGN Cross-sectional study METHODS: We conducted a survey of clinician-scientists in ophthalmology at U.S. academic institutions between April 17, 2019 and May 19, 2019. We collected information including 1) demographic data, 2) amount, type, and source of startup funding, first extramural grant, and first R01-equivalent independent gr...
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#1Christopher B. Toomey (UCSD: University of California, San Diego)H-Index: 11
#2Nicholas J. Protopsaltis (UCSD: University of California, San Diego)H-Index: 2
Last. Jonathan H. LinH-Index: 30
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PURPOSE: Uveal melanomas are associated with characteristic genetic changes. Germline mutations in mismatch repair (MMR) genes and microsatellite instability have been implicated in the development of numerous malignant neoplasms such as colon and ovarian cancers. The frequency of MMR defects in uveal melanomas has yet to be determined. METHODS: Here, we analyzed the frequency of MMR gene mutations in uveal melanoma specimens from the University of California, San Diego (UCSD), The Cancer Genome...
1 CitationsSource
#1Daniel L. Chao (UCSD: University of California, San Diego)H-Index: 13
#2Nicholas J. Protopsaltis (UCSD: University of California, San Diego)H-Index: 2
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#1Nicholas J. Protopsaltis (UCSD: University of California, San Diego)H-Index: 2
#2Wei Liang (UCSD: University of California, San Diego)H-Index: 10
Last. Napoleone Ferrara (UCSD: University of California, San Diego)H-Index: 179
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TH17 cells play important yet complex roles in cancer development and progression. We previously reported that TH17 cells and IL-17 mediate resistance to anti-VEGF therapy by inducing recruitment of immunosuppressive and proangiogenic myeloid cells to the tumor microenvironment. Here, we demonstrate that IL-22, a key effector cytokine expressed by TH17 cells, directly acts on endothelial cells to promote tumor angiogenesis. IL-22 induces endothelial cell proliferation, survival, and chemotaxis i...
9 CitationsSource
#1Nicholas J. Protopsaltis (UCSD: University of California, San Diego)H-Index: 2
#2Allison J. Chen (UCSD: University of California, San Diego)H-Index: 5
Last. Daniel L. Chao (UCSD: University of California, San Diego)H-Index: 13
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Importance Understanding factors associated with attaining independent research funding by ophthalmology clinician-scientists receiving National Eye Institute career development awards (K08 or K23) in ophthalmology can be important to maintaining the pipeline of clinician-scientists. Objective To provide continued follow-up of a cohort of ophthalmology clinician-scientists who received National Institutes of Health (NIH) K career development grants. Design, Setting, and Participants Cohort study...
7 CitationsSource
#1Doran B. SpencerH-Index: 1
Last. Daniel L. ChaoH-Index: 13
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Diabetic retinopathy (DR) is the most common microvascular complication in patients with diabetes mellitus (DM), and remains the single greatest cause of blindness in working age adults around the world. In this article, we review the evolution of pharmacotherapies for both diabetic macular edema (DME) and DR such as anti-vascular endothelial growth factor inhibitors and various steroid formulations, as well as other emerging pharmacotherapies currently in late stage clinical testing for this di...
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