Nationwide epidemiological survey of autoimmune pancreatitis in Japan in 2016.

Published on Apr 1, 2020in Journal of Gastroenterology7.527
路 DOI :10.1007/S00535-019-01658-7
Atsushi Masamune70
Estimated H-index: 70
(Tohoku University),
Kazuhiro Kikuta33
Estimated H-index: 33
(Tohoku University)
+ 4 AuthorsKazuichi Okazaki85
Estimated H-index: 85
(Kansai Medical University)
Background To further clarify the clinico-epidemiological features of autoimmune pancreatitis (AIP) in Japan, we conducted the fourth nationwide epidemiological survey.
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Summary Autoimmune pancreatitis is an unusual form of pancreatitis that is histologically characterised by a massive infiltration of lymphocytes and IgG4-positive plasma cells and storiform fibrosis. The disease is recognised as a pancreatic manifestation of IgG4-related disease. IgG4-related sclerosing cholangitis is a biliary counterpart that is typically associated with autoimmune pancreatitis. Two parallel immunological responses are thought to underlie the pathophysiology of these diseases:...
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In 1995, Yoshida and colleagues proposed the concept of 鈥渁utoimmune pancreatitis鈥 (AIP), which has recently been recognized as a new pancreatic inflammatory disease. Recent studies have suggested the existence of two subtypes of AIP: type 1, which involves immunoglobulin G4 (IgG4) and is the pancreatic manifestation of IgG4-related disease (IgG4-RD); and type 2, which is characterized by granulocytic epithelial lesions. Type 2 AIP is thought to be rare in Japan. Type 1 AIP is characterized by in...
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Background & Aims Immunoglobulin G4 sclerosing cholangitis (IgG4-SC) is a biliary tract manifestation of IgG4-related systemic disease. We investigated the demographics, clinical features at presentation, treatment response, and outcomes of IgG4-SC using data from a large-scale survey in Japan. Methods We performed a retrospective cohort study of 527 patients with IgG4-SC (436 female; median age, 66.2 years; range, 23鈥89 years) in Japan from 2000 to 2015. Data on patient demographics, presentati...
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Diagnostika vzacneho onemocn臎ni autoimunitni pankreatitidou (AIP) je demonstrovana na p艡ipadu pacienta, kter媒 prosel 艡adou vyset艡eni, je啪 nebyla schopna diagnozu benigniho charakteru jednoznacn臎 prokazat. Nemoc je forma chronicke pankreatitidy, p艡icem啪 nejd暖le啪it臎jsim a prvnim cilem vyset艡eni je vylouceni maligniho onemocn臎ni slinivky a 啪lucov媒ch cest. Zatimco zobrazovaci metody vedly k podez艡eni na malignitu, opakovana histologicka vyset艡eni ji nepotvrzovala. Pote, co jsme podle dostupn媒ch diag...
#1S. Lu (JNU: Jinan University)
#2J. Liang (Southern Medical University)
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Autoimmune pancreatitis (AIP), which is characterized by pancreatic enlargement and irregular narrowing of the main pancreatic duct, is difficult to differentiate from malignancy. The irregular narrowing of the pancreatic duct, which can be detected via endoscopic retrograde cholangiopancreatography, is a characteristic feature of AIP; however, distinguishing between localized AIP and pancreatic cancer based on pancreatic duct imaging is difficult. This study overviews the efficacy of endoscopic...
There is conflicting evidence regarding autoimmune pancreatitis (AIP) association with pancreatic and non-pancreatic cancers. Literature lacks data on overall prevalence of malignancies in autoimmune pancreatitis. Given the lack of definite evidence, we aimed to pool and summarize data from available literature regarding prevalence of different malignancies in AIP. We conducted a systematic search of MEDLINE, EMBASE, Cochrane Register of Controlled Trials, and Web of Science through February 16,...
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