Atsushi Masamune
Tohoku University
CancerInternal medicineRadiologyEndocrinologySurgeryPathologyMolecular biologyHepatic stellate cellChemistryImmunologyPancreatitisAcute pancreatitisAutoimmune pancreatitisPancreasPancreatic cancerCancer researchMedicineBiologyGastroenterologyCell biology
502Publications
67H-index
9,385Citations
Publications 503
Newest
#1Yoshiharu Masaki (Sapporo Medical University)H-Index: 7
#2Hiroshi Nakase (Sapporo Medical University)H-Index: 48
Last. Yuzo Kodama (Kobe University)H-Index: 35
view all 14 authors...
The effectiveness of azathioprine (AZA) in preventing relapse and maintaining autoimmune pancreatitis (AIP) remission has been reported; however, most of these studies are case series with no randomized control trials available in the literature. Therefore, this study performed a systematic review and meta-analysis of the existing literature on this subject to determine the clinical efficacy of AZA as maintenance therapy for AIP patients. A systematic search was performed to identify studies on ...
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#1Yu Tanaka (Tohoku University)H-Index: 1
#2Shin Hamada (Tohoku University)H-Index: 35
Last. Atsushi Masamune (Tohoku University)H-Index: 67
view all 6 authors...
It was previously identified that systemic Nrf2-deletion attenuates pancreatic cancer progression in a mutant K-ras/p53-expressing mouse model (KPC mouse). In this study, the type of cell that is responsible for the retarded cancer progression was elucidated. Human pancreatic cancers were first examined, and elevated expression of NRF2-target gene products in a-smooth muscle actin-positive cells was found, suggesting that pancreatic stellate cells (PSCs) are involved in this process. Closer exam...
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#1Yutaro Masu (Tohoku University)H-Index: 1
#2Yoshitake Kanazawa (Tohoku University)H-Index: 11
Last. Hisashi Shiga (Tohoku University)H-Index: 13
view all 0 authors...
Immune response involving various immunoglobulin (Ig) isotypes and subtypes to microbiome is involved in the pathogenesis and disease activity of inflammatory bowel diseases (IBDs). To clarify the presence of Ig-coated bacteria in the intestine and its association with disease activity in ulcerative colitis (UC) and Crohn’s disease (CD), we extracted and classified Ig-coated bacteria from fecal samples of 42 patients with IBD and 12 healthy controls (HCs) using flow cytometry and 16S ribosomal R...
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#1Ryotaro Matsumoto (Tohoku University)H-Index: 1
#2Shin Hamada (Tohoku University)H-Index: 35
Last. Atsushi Masamune (Tohoku University)H-Index: 67
view all 6 authors...
As the central regulator of the oxidative stress response, nuclear factor erythroid 2-related factor 2 (Nrf2) is attracting great interest as a therapeutic target for various cancers, and the possible clinical applications of novel Nrf2 inhibitors have been explored in Nrf2-activated cancers. In the present study, we specifically investigated halofuginone, which is derived from a natural plant alkaloid. We found that halofuginone administration decreased the number of pancreatic intraepithelial ...
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#1Fumiko Shimoda (Tohoku University)H-Index: 1
#2Masatake Kuroha (Tohoku University)H-Index: 12
Last. Hisashi Shiga (Tohoku University)H-Index: 13
view all 13 authors...
Several case reports have described severe postoperative enteritis shortly after total colectomy for ulcerative colitis. The very low incidence of this condition makes diagnosis and treatment difficult, and the appropriate treatment strategy is unclear. We report two cases of enteritis after surgery for ulcerative colitis, which were treated with anti-tumor necrosis factor-α therapy. Case 1 involved a 22-year-old man with symptoms, such as nausea 40 days after total colectomy. Gastrointestinal e...
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#1Tadashi Iida (Nagoya University)H-Index: 5
#2Yuichi Mizutani (Nagoya University)H-Index: 5
Last. Hisashi Haga (Hokkaido University)H-Index: 23
view all 20 authors...
Previous therapeutic attempts to deplete cancer-associated fibroblasts (CAFs) or inhibit their proliferation in pancreatic ductal adenocarcinoma (PDAC) were not successful in mice or patients. Thus, CAFs may be tumor suppressive or heterogeneous, with distinct cancer-restraining and -promoting CAFs (rCAFs and pCAFs, respectively). Here, we show that induced expression of the glycosylphosphatidylinositol-anchored protein Meflin, a rCAF-specific marker, in CAFs by genetic and pharmacological appro...
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#1Takashi Kokumai (Tohoku University)
#2Masamichi Mizuma (Tohoku University)H-Index: 11
Last. Atsushi Masamune (Tohoku University)H-Index: 67
view all 12 authors...
Background null Pancreatic serous cystic neoplasm (SCN) is an uncommon exocrine neoplasm, which is believed to be a benign entity. However, some of these neoplasms may occasionally attain metastatic ability. Von Hippel-Lindau disease (VHL) manifests a dominantly inherited systemic syndrome accompanied by several benign or malignant tumors, including cystic tumors, in various organs. We describe here a long-term survival case who underwent surgical resection for metachronous liver metastases of p...
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#1Tamotsu Matsuhashi (Akita University)H-Index: 16
#2Waku Hatta (Tohoku University)H-Index: 13
Last. Yohei Ogata (Tohoku University)H-Index: 2
view all 26 authors...
BACKGROUND No prediction scores for the mortality of both inpatients and outpatients who developed nonvariceal upper gastrointestinal bleeding (UGIB) without endoscopic findings have been established. We aimed to derive and validate a novel prediction score for in-hospital mortality. METHODS We conducted a three-stage, multicenter retrospective study. In the derivation stage, patients with nonvariceal UGIB at six institutions were enrolled to derive the prediction score by logistic regression an...
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The envelope of hepatitis B virus (HBV), which is required for the entry to hepatocytes, consists of a lipid bilayer derived from hepatocyte and HBV envelope proteins, large/middle/small hepatitis B surface antigen (L/M/SHBs). The mechanisms and host factors for the envelope formation in the hepatocytes are being revealed. HBV-infected hepatocytes release a large amount of subviral particles (SVPs) containing L/M/SHBs that facilitate escape from the immune system. Recently, novel drugs inhibitin...
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