Kazuichi Okazaki
Kansai Medical University
Internal medicineRadiologyBalloonSurgeryPathologyImmunologyColitisPancreatitisAutoimmune pancreatitisPancreasDiseasePancreatic cancerIgG4-related diseaseFibrosisIn patientHepatologyGeneral surgeryMedicineBiologyGastroenterology
Publications 699
#1Masayasu HoribeH-Index: 8
#2Eisuke IwasakiH-Index: 18
Last. Takanori KanaiH-Index: 71
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#1Yumie Kobayashi (OCU: Osaka City University)H-Index: 1
#1Yumie Kobayashi (OCU: Osaka City University)H-Index: 1
Last. Akira SugitaH-Index: 20
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BACKGROUND Dietary fatty acids can affect chronic intestinal inflammation and have been reported to be associated with the development of ulcerative colitis (UC), mainly in Europe and the United States. The association of dietary intake of fatty acids and the risk for UC was investigated in Japan, where dietary habits lead to lower meat and higher fish consumption than in Western countries. METHODS A multicenter case-control study of 83 newly diagnosed patients with UC and 128 age- and sex-match...
1 CitationsSource
#1Motonobu Maruo (Kansai Medical University)
#2Tomomitsu Tahara (Kansai Medical University)H-Index: 2
Last. Makoto Naganuma (Kansai Medical University)H-Index: 36
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RATIONALE Brunner gland hamartoma (BGH) is a rare tumor of the duodenum. Although BGH is a benign tumor, larger lesion with gastrointestinal symptoms requires tumor removal. We report a giant BGH, successfully treated by endoscopic excision followed by transanal retrieval. PATIENT CONCERNS A 38-year-old woman complained of severe anemia, tarry stool, and vomiting. DIAGNOSES Esophagogastroduodenoscopy (EGD) showed a pedunculated giant submucosal mass at the duodenal bulb. INTERVENTIONS We attempt...
#1Takahiro Nakazawa (Nagoya City University)H-Index: 29
#2Terumi KamisawaH-Index: 77
Last. Michiaki Unno (Tohoku University)H-Index: 67
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Background Several years have passed since the clinical diagnostic criteria for IgG4-related sclerosing cholangitis 2012 were published. New findings and knowledge have accumulated since then. Methods The Research Committees for IgG4-related Diseases and for Intractable Diseases of the Liver and Biliary Tract in association with the Ministry of Health, Labor and Welfare of Japan and the Japan Biliary Association, have established a working group consisting of researchers specializing in IgG4-SC ...
#1Itaru Naitoh (Nagoya City University)H-Index: 20
#2Terumi KamisawaH-Index: 77
Last. Kazuichi Okazaki (Kansai Medical University)H-Index: 83
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Abstract Background The clinical characteristics of IgG4-related sclerosing cholangitis (IgG4-SC) especially without autoimmune pancreatitis (AIP) have not been investigated in a large cohort. Aims To clarify the clinical characteristics of IgG4-SC and IgG4-SC without AIP. Methods We retrospectively reviewed imaging, serology, other organ involvement (OOI) and histology of 872 patients with IgG4-SC who participated in a Japanese nationwide survey in 2019, and compared these items between IgG4-SC...
#1Jun Zhang (SJTU: Shanghai Jiao Tong University)H-Index: 115
#1Jun Zhang (SJTU: Shanghai Jiao Tong University)H-Index: 57
Last. Xiong Ma (SJTU: Shanghai Jiao Tong University)
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IgG4-related disease (IgG4-RD) is characterized by intense infiltration of IgG4-positive plasma cells in affected organs. However, the mechanisms acting in the immune responses in IgG4-RD are not fully understood. The aim of this study was to dissect the mechanism underlying the immunoglobulin class switch in IgG4-RD by addressing the crosstalk between IL-35-producing and Th9 cells. The expression level of IL-35 was examined in plasma samples from patients with hepatobiliary and/or pancreatic ma...
2 CitationsSource
#1Hisanori UmeharaH-Index: 56
#2Kazuichi Okazaki (Kansai Medical University)H-Index: 83
Last. Mitsuhiro Kawano (Kanazawa University)H-Index: 34
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IgG4-related disease (IgG4-RD) is a fascinating clinical entity first reported in this century in Japan, and includes a wide variety of diseases, such as formerly named Mikulicz's disease (MD), autoimmune pancreatitis (AIP), interstitial nephritis, prostatitis and retroperitoneal fibrosis. The Japanese IgG4 team organized by the Ministry of Health, Labor and Welfare (MHLW) of Japan has published the first criteria, comprehensive diagnostic (CD) criteria for IgG-RD 2011. Thereafter, IgG4-RD has b...
2 CitationsSource
#1Makoto Takaoka (Kansai Medical University)H-Index: 24
#2Masaaki Shimatani (Kansai Medical University)H-Index: 17
Last. Makoto Naganuma (Kansai Medical University)H-Index: 3
view all 13 authors...
Self-expandable metallic stents (SEMSs) are widely used for malignant biliary stricture (MBS). Acute pancreatitis is an early complication following SEMS placement. In the present case, the patient developed severe acute pancreatitis after SEMS placement for MBS because of metastatic lymph nodes. Endoscopic retrograde cholangiopancreatography, endoscopic sphincterotomy and an endoscopic nasobiliary drainage tube placement were performed. After seven days, an uncovered SEMS was placed; however, s...
#1Annarosa Floreani (UNIPD: University of Padua)H-Index: 58
#2Kazuichi Okazaki (Kansai Medical University)H-Index: 83
Last. M. Eric Gershwin (UC Davis: University of California, Davis)H-Index: 137
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IgG4-related disease (IgG4-RD) represents an immune-mediated fibroinflammatory condition with peculiar histopathologic changes that can affect various organs. In 2012 its unified nomenclature was published, which allows to abandon other synonymous names. Up to now, only little is known about its epidemiology around the world. However, although it is generally considered a rare condition, the number of patients with IgG4-RD is increasing enormously. Likewise, the annual number of publications on ...
#1Manami IkemuneH-Index: 2
#2Kazushige UchidaH-Index: 30
Last. Kazuichi OkazakiH-Index: 83
view all 12 authors...
Introduction Type 1 autoimmune pancreatitis is a chronic fibro-inflammatory disorder. We previously reported the involvement of M2 macrophages and basophils in autoimmune pancreatitis. It is reported that Group 2 innate lymphoid cells (ILC2s) and basophils play an important role in asthma. Thus, this study investigated the roles of innate lymphoid cells in autoimmune pancreatitis. Subjects and methods We recruited 28 patients with autoimmune pancreatitis (25 men and 3 women; mean age, 68.4 years...