Kazuichi Okazaki
Kansai Medical University
Internal medicineRadiologyBalloonSurgeryPathologyImmunologyColitisPancreatitisAutoimmune pancreatitisPancreasDiseasePancreatic cancerIgG4-related diseaseFibrosisIn patientHepatologyGeneral surgeryMedicineBiologyGastroenterology
700Publications
85H-index
20.4kCitations
Publications 696
Newest
#1Yoshiharu Masaki (Sapporo Medical University)H-Index: 7
#2Hiroshi Nakase (Sapporo Medical University)H-Index: 48
Last. Yuzo Kodama (Kobe University)H-Index: 35
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The effectiveness of azathioprine (AZA) in preventing relapse and maintaining autoimmune pancreatitis (AIP) remission has been reported; however, most of these studies are case series with no randomized control trials available in the literature. Therefore, this study performed a systematic review and meta-analysis of the existing literature on this subject to determine the clinical efficacy of AZA as maintenance therapy for AIP patients. A systematic search was performed to identify studies on ...
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#1Masahiro Takeo (Kansai Medical University)H-Index: 3
#2Akiyoshi Nishio (Kansai Medical University)H-Index: 25
Last. Kazuichi Okazaki (Kansai Medical University)H-Index: 85
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Background null Stimulation of Toll-like receptor 3 (TLR3) induces autoimmune-mediated pancreatitis in susceptible mice, whereas stimulation of TLR4 causes nonautoimmune-mediated pancreatitis. However, the effects of TLR2 stimulation on the pancreas are unknown. null Aims null We investigated the role of TLR2 stimulation on pancreatic damage by repeatedly stimulating mice with TLR2 ligands. null Methods null Wild-type (WT) and interleukin 10-deficient (IL-10-knockout (KO)) mice were administered...
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#1Makoto Takaoka (Kansai Medical University)H-Index: 24
#2Masaaki Shimatani (Kansai Medical University)H-Index: 17
Last. Makoto Naganuma (Kansai Medical University)H-Index: 3
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Self-expandable metallic stents (SEMSs) are widely used for malignant biliary stricture (MBS). Acute pancreatitis is an early complication following SEMS placement. In the present case, the patient developed severe acute pancreatitis after SEMS placement for MBS because of metastatic lymph nodes. Endoscopic retrograde cholangiopancreatography, endoscopic sphincterotomy and an endoscopic nasobiliary drainage tube placement were performed. After seven days, an uncovered SEMS was placed; however, s...
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#1Shunsuke Horitani (Kansai Medical University)H-Index: 1
#2Toshiro Fukui (Kansai Medical University)H-Index: 22
Last. Kazuichi Okazaki (Kansai Medical University)H-Index: 85
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BACKGROUND There is little known about stem cells in human non-neoplastic and neoplastic esophageal epithelia. We have demonstrated expression of linker threonine-phosphorylated Smad2/3 (pSmad2/3L-Thr), suggesting presence of stem-like cells in mouse esophageal epithelium, and identified presence of pSmad2/3L-Thr-positive cells that might function as cancer stem cells in mouse model of colorectal carcinoma. AIMS We explore whether pSmad2/3L-Thr can be used as a biomarker for stem cells of human ...
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#1Masayasu HoribeH-Index: 8
#2Eisuke IwasakiH-Index: 18
Last. Takanori KanaiH-Index: 70
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#1Yumie Kobayashi (OCU: Osaka City University)H-Index: 1
#1Yumie Kobayashi (OCU: Osaka City University)H-Index: 1
Last. Akira SugitaH-Index: 20
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BACKGROUND Dietary fatty acids can affect chronic intestinal inflammation and have been reported to be associated with the development of ulcerative colitis (UC), mainly in Europe and the United States. The association of dietary intake of fatty acids and the risk for UC was investigated in Japan, where dietary habits lead to lower meat and higher fish consumption than in Western countries. METHODS A multicenter case-control study of 83 newly diagnosed patients with UC and 128 age- and sex-match...
1 CitationsSource
#1Motonobu Maruo (Kansai Medical University)
#2Tomomitsu Tahara (Kansai Medical University)H-Index: 2
Last. Makoto Naganuma (Kansai Medical University)H-Index: 36
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RATIONALE Brunner gland hamartoma (BGH) is a rare tumor of the duodenum. Although BGH is a benign tumor, larger lesion with gastrointestinal symptoms requires tumor removal. We report a giant BGH, successfully treated by endoscopic excision followed by transanal retrieval. PATIENT CONCERNS A 38-year-old woman complained of severe anemia, tarry stool, and vomiting. DIAGNOSES Esophagogastroduodenoscopy (EGD) showed a pedunculated giant submucosal mass at the duodenal bulb. INTERVENTIONS We attempt...
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#1Takahiro Nakazawa (Nagoya City University)H-Index: 29
#2Terumi KamisawaH-Index: 77
Last. Tosiaki Unno (Tohoku University)
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Background Several years have passed since the clinical diagnostic criteria for IgG4-related sclerosing cholangitis 2012 were published. New findings and knowledge have accumulated since then. Methods The Research Committees for IgG4-related Diseases and for Intractable Diseases of the Liver and Biliary Tract in association with the Ministry of Health, Labor and Welfare of Japan and the Japan Biliary Association, have established a working group consisting of researchers specializing in IgG4-SC ...
2 CitationsSource
#1Itaru Naitoh (Nagoya City University)H-Index: 22
#2Terumi KamisawaH-Index: 77
Last. Kazuichi Okazaki (Kansai Medical University)H-Index: 85
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Abstract Background The clinical characteristics of IgG4-related sclerosing cholangitis (IgG4-SC) especially without autoimmune pancreatitis (AIP) have not been investigated in a large cohort. Aims To clarify the clinical characteristics of IgG4-SC and IgG4-SC without AIP. Methods We retrospectively reviewed imaging, serology, other organ involvement (OOI) and histology of 872 patients with IgG4-SC who participated in a Japanese nationwide survey in 2019, and compared these items between IgG4-SC...
1 CitationsSource
#1Jun Zhang (SJTU: Shanghai Jiao Tong University)H-Index: 57
#1Jun Zhang (SJTU: Shanghai Jiao Tong University)H-Index: 119
Last. Xiong Ma (SJTU: Shanghai Jiao Tong University)H-Index: 30
view all 21 authors...
IgG4-related disease (IgG4-RD) is characterized by intense infiltration of IgG4-positive plasma cells in affected organs. However, the mechanisms acting in the immune responses in IgG4-RD are not fully understood. The aim of this study was to dissect the mechanism underlying the immunoglobulin class switch in IgG4-RD by addressing the crosstalk between IL-35-producing and Th9 cells. The expression level of IL-35 was examined in plasma samples from patients with hepatobiliary and/or pancreatic ma...
4 CitationsSource