Detection of PLA2R Autoantibodies before the Diagnosis of Membranous Nephropathy

Significance Statement Primary membranous nephropathy (MN) is an autoimmune glomerular disease associated with nephrotic syndrome and poor kidney prognosis. Autoantibodies against the M-type phospholipase A2 receptor (PLA2R-AB) are present at diagnosis in about 70% of cases. However, when PLA2R-AB first appear and their trajectory are unknown. The authors used the Department of Defense Serum Repository to describe the prediagnostic evolution of...