Journal of The American Society of Nephrology
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9748
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#1Paulo S. Caceres (HFH: Henry Ford Hospital)H-Index: 9
#2Gina Savickas (HFH: Henry Ford Hospital)
Last. Pablo A. Ortiz (HFH: Henry Ford Hospital)H-Index: 31
view all 16 authors...
Background Acute kidney injury (AKI) is a complication of coronavirus disease 2019 (COVID-19) that is associated with high mortality. Despite documented kidney tropism of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), there are no consistent reports of viral detection in urine or correlation with AKI or COVID-19 severity. Here we hypothesize that quantification of SARS-CoV-2 viral load in urine sediment from COVID-19 patients correlates with occurrence of AKI and mortality. Me...
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#1Sri Lekha Tummalapalli (Cornell University)H-Index: 5
#2Jeffrey Silberzweig (The Rogosin Institute)H-Index: 6
Last. Said A. Ibrahim (Cornell University)H-Index: 49
view all 10 authors...
Background The coronavirus disease 2019 (COVID-19) pandemic has disproportionately affected socially disadvantaged populations. Whether disparities in COVID-19 incidence related to race/ethnicity and socioeconomic factors exist in the hemodialysis population is unknown. Methods Our study involved patients receiving in-center hemodialysis in New York City. We used a validated index of neighborhood social vulnerability, the Social Vulnerability Index (SVI), which comprises 15 census tract-level in...
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#1Sato Magassa (University of Paris)
#2Liviu Aron (Harvard University)H-Index: 14
Last. Guillaume Canaud (University of Paris)H-Index: 1
view all 8 authors...
BACKGROUND Chronic kidney disease is associated with the loss of functional nephrons, leading to increased mechanical and metabolic stress in the remaining cells, particularly for cells constituting the filtration barrier, such as podocytes. The failure of podocytes to mount an adequate stress response can lead to further nephron loss and disease progression. However, the mechanisms that regulate this degenerative process in the kidney are unknown. METHODS We combined in vitro, in vivo, and orga...
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#1Konrad BuscherH-Index: 15
#2Barbara Heitplatz (WWU: University of Münster)H-Index: 8
Last. Stefan ReuterH-Index: 28
view all 13 authors...
BACKGROUND In transplant medicine, clinical decision-making largely relies on histology of biopsies. However, histology suffers from low specificity, sensitivity, and reproducibility, leading to suboptimal stratification of patients. We developed a histology-independent immune framework of kidney graft homeostasis and rejection. METHODS Tailored RNA deconvolution for leukocyte enumeration and co-regulated gene network analysis was applied to published bulk human kidney transplant RNA transcripto...
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#1Theresa Dornieden (Charité)
#2Arne Sattler (Charité)H-Index: 12
Last. Katja Kotsch (Charité)H-Index: 28
view all 13 authors...
BACKGROUND Tissue-resident memory (TRM) T cells are known to be important for the first line of defense in mucosa-associated tissues. However, the composition, localization, effector function, and specificity of TRM T cells in the human kidney and their relevance for renal pathology have not been investigated. METHODS Lymphocytes derived from blood, renal peri-tumor samples, and tumor samples were phenotypically and functionally assessed by applying flow cytometry and highly advanced histology (...
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#1Favian A. Hatje (UHH: University of Hamburg)H-Index: 1
#2Uta Wedekind (UHH: University of Hamburg)H-Index: 1
Last. Catherine Meyer-Schwesinger (UHH: University of Hamburg)H-Index: 30
view all 15 authors...
Background: The glomerulus comprises podocytes, mesangial, and endothelial cells, which jointly determine glomerular filtration. Understanding this intricate functional unit beyond the transcriptome requires bulk isolation of these cell-types for biochemical investigations. We developed a globally applicable t ripartite i solation method for m urine m esangial and e ndothelial cells and p odocytes (timMEP). Methods: Glomerular cell-types were separated via a novel FACS-sort approach from wildtyp...
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#1Sophia Sears (University of Louisville)H-Index: 1
#2Leah J. Siskind (University of Louisville)H-Index: 24
The effectiveness of cisplatin, a mainstay in treatment of many solid organ cancers, is hindered by dose-limiting nephrotoxicity. Cisplatin causes acute kidney injury (AKI) in 30% of patients. Patients who do not develop AKI by clinical standards during the course of treatment are still at risk for long-term decline in kidney function and the development of chronic kidney disease (CKD). The connection between AKI and CKD has become increasingly studied, with renal fibrosis being a hallmark of CK...
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#1Lei Dai (CSU: Central South University)H-Index: 1
#2Jingzhi Li (CSU: Central South University)
Last. Weishe Zhang (CSU: Central South University)H-Index: 3
view all 12 authors...
Background: Bilateral renal agenesis (BRA) is a lethal congenital anomaly caused by the failure of normal development of both kidneys early in embryonic development. Oligohydramnios upon fetal ultrasonography reveals BRA. Although exact causes are not clear, BRA is associated with mutations in many renal development genes. However, molecular diagnostics cannot pick up many clinical cases. Nephronectin (NPNT) may be a candidate protein for widening diagnosis. It is essential in kidney development...
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#1Michael J. Randles (Wellcome Trust Centre for Cell-Matrix Research)H-Index: 10
#2Franziska Lausecker (Wellcome Trust Centre for Cell-Matrix Research)H-Index: 4
Last. Rachel Lennon (Wellcome Trust Centre for Cell-Matrix Research)H-Index: 26
view all 16 authors...
Background: Accumulation of extracellular matrix in organs and tissues is a feature of both aging and disease. In the kidney, glomerulosclerosis and tubulointerstitial fibrosis accompany the decline in function, which current therapies cannot address, leading to organ failure. Whilst histological and ultrastructural patterns of excess matrix form the basis of human disease classifications, comprehensive molecular resolution of abnormal matrix is lacking. Methods: Using mass spectrometry-based pr...
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