Journal of The American Society of Nephrology
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Background: Although reinfection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is rare among individuals with few coronavirus disease 2019 (COVID-19) risk factors, the ability of naturally acquired immunity to prevent reinfection among patients with end-stage kidney disease (ESKD) is not known. Methods: This prospective study was conducted among adults with ESKD treated with in-center hemodialysis (ICHD) in the United States. Exposure was ascribed based on the presence or abs...
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#1Magnus Althage (AstraZeneca)H-Index: 5
#2Timothy Heinrich (Wake Forest University)H-Index: 2
Last. Judith Hartleib-Geschwindner (AstraZeneca)H-Index: 5
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#1Zhiheng Liu (MOE: Chinese Ministry of Education)
#2Yunjing Liu (MOE: Chinese Ministry of Education)
Last. Yupeng Chen (MOE: Chinese Ministry of Education)
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Background Genome-wide mapping of transcription factor (TF) binding sites is essential to identify a TF's direct target genes in kidney development and diseases. However, due to the cellular complexity of the kidney and limited numbers of a given cell type, it has been challenging to determine the binding sites of a TF in vivo. cAMP-response element-binding protein (CREB) is phosphorylated and hyperactive in autosomal dominant polycystic kidney disease (ADPKD). We focus on CREB as an example to ...
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#1Suphamai Bunnapradist (UCLA: University of California, Los Angeles)H-Index: 62
#2Piyavadee Homkrailas (UCLA: University of California, Los Angeles)H-Index: 1
Last. Hossein Tabriziani (Natera)
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Soluble Fms-like tyrosine kinase (sFlt-1/sVEGFR1) is a natural occurring antagonist of vascular endothelial growth factor (VEGF). Despite being a secreted, soluble protein lacking cytoplasmic and transmembrane domains, sFlt-1 can act locally and be protective against excessive microenvironmental VEGF concentration, or exert autocrine functions independently of VEGF. Circulating sFlt-1 may indiscriminately affect endothelial function and the microvasculature on distant target organs. The clinical...
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#1Adrián CordidoH-Index: 2
Last. Terry Watnick (UMB: University of Maryland, Baltimore)H-Index: 41
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Background: In autosomal dominant polycystic kidney disease (ADPKD), cyst development and enlargement lead to end-stage kidney disease. Macrophage recruitment and interstitial inflammation have been shown to promote cyst growth. TWEAK is a TNF superfamily (TNFSF) cytokine that regulates inflammatory responses, cell proliferation and cell death, and its receptor Fn14 (TNFRSF12a) is expressed in macrophage and nephron epithelia. Methods: In order to evaluate the role of the TWEAK signaling pathway...
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#1Yueh-An Lu (Cardiff University)
#2Chia-Te Liao (Memorial Hospital of South Bend)
Last. Donald James Fraser (Cardiff University)H-Index: 28
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Background null Proximal tubular cells (PTCs) are the most abundant cell type in the kidney. PTCs are central to normal kidney function and to regeneration versus organ fibrosis following injury. This study used single-nucleus RNA sequencing (snRNA-seq) to describe the phenotype of PTCs in renal fibrosis. null Methods null Kidneys were harvested from naive mice and from mice with renal fibrosis induced by chronic aristolochic acid administration. Nuclei were isolated using Nuclei EZ Lysis buffer...
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#1Idris BoudhabhayH-Index: 6
#2Florence Delestre (Paris V: Paris Descartes University)H-Index: 1
Last. Clément GossetH-Index: 6
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Background Renal involvement in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is associated with poor outcomes. The clinical significance of arteritis of the small kidney arteries has not been evaluated in detail. Methods In a multicenter cohort of AAV patients with renal involvement, we sought to describe the clinicopathologic characteristics of patients with AAV who had renal arteritis at diagnosis and to retrospectively analyze their prognostic value. Results We inclu...
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