Journal of The American Society of Nephrology
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Background: Hemodialysis patients as well as healthcare workers are considered to be in a high-risk category for SARS-CoV-2 infection and a priority for vaccination. Methods: In a single-center out-patient hemodialysis unit, 46 healthcare workers and 216 patients were vaccinated simultaneously with BNT162b2 (BioNTech-Pfizer) vaccine. They received two doses, 21 days apart. The primary objectives were to evaluate the safety and efficacy of the vaccine. Results: There were no major adverse events ...
#1Melissa H. LittleH-Index: 60
#2Benjamin D. Humphreys (WUSTL: Washington University in St. Louis)H-Index: 57
Fifteen years ago, this journal published a review outlining future options for regenerating the kidney. At that time, stem cell populations were being identified in multiple tissues, the concept of stem cell recruitment to a site of injury was of great interest, and the possibility of postnatal renal stem cells was growing in momentum. Since that time, we have seen the advent of human induced pluripotent stem cells, substantial advances in our capacity to both sequence and edit the genome, glob...
#1Scott SibbelH-Index: 8
#2Katherine McKeonH-Index: 1
Last. Steven M. BrunelliH-Index: 36
view all 12 authors...
Background Patients on hemodialysis have an elevated risk for COVID-19 infection but were not included in efficacy trials of SARS-CoV-2 vaccines. Methods We conducted a retrospective, observational study to estimate the real-world effectiveness and immunogenicity of two mRNA SARS-CoV-2 vaccines in a large, representative population of adult hemodialysis patients in the United States. In separate, parallel analyses, patients who began a vaccination series with BNT162b2 or mRNA-1273 in January and...
#1Ziyad Al-AlyH-Index: 43
#1Chengqing Qu (WUSTL: Washington University in St. Louis)
#2Robyn Roth (WUSTL: Washington University in St. Louis)H-Index: 36
Last. Hani Suleiman (WUSTL: Washington University in St. Louis)H-Index: 10
view all 8 authors...
Background Actin stress fibers are abundant in cultured cells, but little is known about them in vivo In podocytes, much evidence suggests that mechanobiologic mechanisms underlie podocyte shape and adhesion in health and in injury, with structural changes to actin stress fibers potentially responsible for pathologic changes to cell morphology. However, this hypothesis is difficult to rigorously test in vivo due to challenges with visualization. A technology to image the actin cytoskeleton at hi...
#1Andrew J. R. Watts (BWH: Brigham and Women's Hospital)H-Index: 10
#2Keith Keller (BWH: Brigham and Women's Hospital)H-Index: 4
Last. Astrid Weins (BWH: Brigham and Women's Hospital)H-Index: 21
view all 20 authors...
Background Failure of the glomerular filtration barrier, primarily by loss of slit diaphragm architecture, underlies nephrotic syndrome in minimal change disease. The etiology remains unknown. The efficacy of B cell-targeted therapies in some patients, together with the known proteinuric effect of antinephrin antibodies in rodent models, prompted us to hypothesize that nephrin autoantibodies may be present in patients with minimal change disease. Methods We evaluated sera from patients with mini...
#1Samir S. El-Dahr (Tulane University)H-Index: 29
#1Janina Müller-Deile (FAU: University of Erlangen-Nuremberg)H-Index: 13
#2Nina Sopel (FAU: University of Erlangen-Nuremberg)H-Index: 8
Last. Gunther ZahnerH-Index: 25
view all 11 authors...
Background null Autoantibodies binding to podocyte antigens cause idiopathic membranous glomerulonephritis (iMGN). However, it remains elusive how autoantibodies reach the subepithelial space because the glomerular filtration barrier (GFB) is size selective and almost impermeable for antibodies. null Methods null Kidney biopsies from patients with iMGN, cell culture, zebrafish, and mouse models were used to investigate the role of nephronectin (NPNT) regulating microRNAs (miRs) for the GFB. null...
#1Joshua Walker (CIS: Cardiovascular Institute of the South)H-Index: 13
#2Sean Richards (BU: Boston University)H-Index: 5
Last. Norman Lee (BU: Boston University)H-Index: 12
view all 13 authors...
Background null CKD, characterized by retained uremic solutes, is a strong and independent risk factor for thrombosis after vascular procedures . Urem ic solutes such as indoxyl sulfate (IS) and kynurenine (Kyn) mediate prothrombotic effect through tissue factor (TF). IS and Kyn biogenesis depends on multiple enzymes, with therapeutic implications unexplored. We examined the role of indoleamine 2,3-dioxygenase-1 (IDO-1), a rate-limiting enzyme of kynurenine biogenesis, in CKD-associated thrombos...
#1Hannah KaminskiH-Index: 5
#2Gabriel MarsèresH-Index: 2
Last. Julie Déchanet-Merville (CNRS: French National Centre for Scientific Research)H-Index: 29
view all 19 authors...
Background: The reported association of mTOR-inhibitor (mTORi) treatment with a lower incidence of cytomegalovirus (CMV) infection in CMV-seropositive (R+) kidney transplant recipients (KTR) remains unexplained. Methods: The incidence of CMV infection and T-cell profile was compared between mTORi- treated and mycophenolic acid (MPA)-treated KTR, and mTORi effects in vitro on T-cell phenotype and functions analyzed. Results: In MPA-treated R+ KTR, both αβ and γδ T-cells displayed a more dysfuncti...
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