Self-nanoemulsifying drug delivery system of fisetin: Formulation, optimization, characterization and cytotoxicity assessment

Published on Dec 1, 2019in Journal of Drug Delivery Science and Technology2.734
· DOI :10.1016/J.JDDST.2019.101252
Rajan Kumar5
Estimated H-index: 5
(LPU: Lovely Professional University),
Rubiya Khursheed9
Estimated H-index: 9
(LPU: Lovely Professional University)
+ 8 AuthorsAshish Wadhwani10
Estimated H-index: 10
Abstract Fisetin is a plant derived flavonoid that possesses anti-cancer, anti-oxidant and anti-Parkinson's activities. However, due to its lipophilicity it suffers from dissolution rate limited oral bioavailability that reduces its therapeutic efficacy. In order to overcome this issue self-nanoemulsifying drug delivery system (SNEDDS) of fisetin were formulated and characterized for droplet size, shape, zeta potential, cell viability, dissolution and permeability studies. Prepared SNEDDS (1.2 mL) were composed of castor oil (0.1 mL), Lauroglycol FCC (0.1 mL), tween 80 (0.4 mL), Transcutol P (0.6 mL) and fisetin (5 mg). The formulation was optimized using Box Behnken Design. Droplet size and zeta potential of optimized SNEDDS were found to be 154 nm and −37 mV. Dissolution rate of fisetin got significantly (p
📖 Papers frequently viewed together
5 Citations
8 Citations
#1Varun Garg (LPU: Lovely Professional University)H-Index: 7
#2Puneet Kaur (WSU: Washington State University)H-Index: 1
Last. Sheetu Wadhwa (LPU: Lovely Professional University)H-Index: 13
view all 12 authors...
Abstract An attempt has been made to prepare solid self-nanoemulsifying drug delivery system (SNEDDS) of polypeptide-k (PPK) and curcumin (CRM) using Labrafil M1944 CS as oil, Tween-80 as surfactan...
12 CitationsSource
#1Sadaf Chaudhary (Jamia Hamdard)H-Index: 1
#2Mohd. Aqil (Jamia Hamdard)H-Index: 29
Last. Mohd Abul Kalam (KSU: King Saud University)H-Index: 17
view all 4 authors...
Abstract The present research work explored the prospective of self-nanoemulsifying drug delivery system (SNEDDS) to improve the oral bioavailability of NBT and its anti-inflammatory effect. Nabumetone (NBT) is a poorly aqueous soluble drug that demonstrates low bioavailability after oral administration. NBT-SNEDDS was prepared by using Capryol-90, Tween-80 and polyethylene glycol-400 (PEG-400) via pseudo-ternary phase diagram. Different components of SNEDDS were curtained and found an optimal r...
13 CitationsSource
#1Jeand Baloch (IIUI: International Islamic University, Islamabad)H-Index: 1
#2Muhammad Farhan Sohail (Riphah International University)H-Index: 12
Last. Gul Shahnaz (QAU: Quaid-i-Azam University)H-Index: 22
view all 10 authors...
Background and Objectives: Lipid-based self-nanoemulsifying drug delivery systems (SNEDDS) have resurged the eminence of nanoemulsions by modest adjustments and offer many valuable opportunities in drug delivery. Chlorpromazine, an antipsychotic agent with poor aqueous solubility—with extensive first-pass metabolism—can be a suitable candidate for the development of SNEDDS. The current study was designed to develop triglyceride-based SNEDDS of chlorpromazine to achieve improved solubility, stabi...
15 CitationsSource
#1Mohsin Kazi (KSU: King Saud University)H-Index: 9
#2Mohammed Al-Swairi (KSU: King Saud University)H-Index: 1
Last. Muhammad Delwar Hussain (Health Science University)H-Index: 15
view all 9 authors...
Objective: The aim of this study was to investigate the in vitro and in vivo performance of self-nanoemulsifying drug delivery systems (SNEDDS) of talinolol (TAL), a poorly water soluble drug. Method: SNEDDS of TAL were prepared using various oils, non-ionic surfactants and/or water-soluble co-solvents and assessed visually/by droplet size measurement. Equilibrium solubility of TAL in the anhydrous and diluted SNEDDS was conducted to achieve the maximum drug loading. The in vitro dissolution exp...
32 CitationsSource
#1Mohammad A. Altamimi (KSU: King Saud University)H-Index: 15
#2Mohsin Kazi (KSU: King Saud University)H-Index: 9
Last. Mohammad Raish (KSU: King Saud University)H-Index: 22
view all 5 authors...
AbstractThe purpose of this work is to develop novel lipid-based self-nanoemulsifying drug delivery systems (SNEDDS) as carriers for transdermal delivery of curcumin. SNEDDS containing black seed o...
11 CitationsSource
#1Afreen Usmani (Integral University)H-Index: 5
#2Anuradha Mishra (Integral University)H-Index: 7
Last. Asif Jafri (LU: University of Lucknow)H-Index: 8
view all 4 authors...
AbstractObjective: The development of self nano emulsifying co-delivery system of doxorubicin and Nigella sativa oil for potentiating the anticancer effects against HepG2 cell lines.Materials and m...
11 CitationsSource
#1Eman Abd-Elhakeem (Cairo University)H-Index: 1
#2Mahmoud Hm. Teaima (Cairo University)H-Index: 1
Last. Galal M. El Mahrouk (Cairo University)H-Index: 2
view all 4 authors...
Abstract The purpose of this study is to develop solid self-nanoemulsifying drug delivery systems (S-SNEDDS) for oral bioavailability enhancement of Clopidogrel (CLP). CLP is an anti-platelet drug used to prevent heart strokes. It suffers from low bioavailability due to extensive hepatic metabolism. Two pseudo-ternary phase diagrams were constructed using different oils, bioenhancing surfactants and co-surfactants. SNEDDS were evaluated for their globule size, polydispersity index and in-vitro d...
13 CitationsSource
#1Rae Man Kim (Inje University)H-Index: 2
#2Dong-Jin Jang (Inje University)H-Index: 5
Last. Kwan Hyung Cho (Inje University)H-Index: 15
view all 7 authors...
The aim of this work was to prepare and optimize a solid self-nanoemulsifying drug delivery system pre-concentrate (SSP) containing water-insoluble flurbiprofen (FL) using a novel pseudo-ternary phase diagram. The pseudo-ternary phase diagram, composed of FL as the drug and dispersion core, Kollisolv MCT 70 as the oil phase, and TPGS (tocopherol polyethylene glycol 1000 succinate) as the surfactant, was constructed for the determination of the SSP region. SSP was investigated in terms of particl...
14 CitationsSource
#1Yandi Syukri (UII: Islamic University of Indonesia)H-Index: 5
#2Ronny Martien (UGM: Gadjah Mada University)H-Index: 9
Last. Agung Endro Nugroho (UGM: Gadjah Mada University)H-Index: 11
view all 4 authors...
Abstract This study aimed to conduct a preparation and characterization of andrographolide isolated from Andrographis paniculata Nees (AND)-loaded Self-Nano Emulsifying Drug Delivery System (SNEDDS) to improve its oral dissolution and bioavailability. The selection of oil, surfactant and co-surfactant components for preliminary screening of self-nano emulsifying formulation was determined by solubility study of AND in various vehicles. Ternary phase diagrams were constructed to identify the nano...
20 CitationsSource
#1Parth Sharma (LPU: Lovely Professional University)H-Index: 4
#2Sachin Kumar Singh (LPU: Lovely Professional University)H-Index: 19
Last. Rubiya Khursheed (LPU: Lovely Professional University)H-Index: 9
view all 16 authors...
Abstract In the present study, different solid self-nanoemulsifying drug delivery system (S-SNEDDS) was formulated by using porous hydrophilic and hydrophobic carriers to improve the dissolution rate and bioavailability of simvastatin (SIM). The prepared liquid-SNEDDS composed of Labrafil M 1944 CS/ Tween-80/ Ethanol (20% / 53.33%/26.67% v/v) with 0.1% SIM, resulted droplet size of 40.69 nm. The hydrophobic carriers used were Aerosil-200, Syloid 244FP, Syloid XDP 3150, Magnesium stearate, Micro ...
11 CitationsSource
Cited By16
#1Shadab (KAU: King Abdulaziz University)H-Index: 24
#2Nabil A. Alhakamy (KAU: King Abdulaziz University)H-Index: 13
Last. Hani Z. Asfour (KAU: King Abdulaziz University)H-Index: 14
view all 6 authors...
Abstract Pancreatic cancers are mostly inoperable and have a low survival rate. Nanomedicine has provided some promise in overcoming some major hurdles in pancreatic cancer. Meanwhile, resveratrol (RESV) has been reported to be useful in pancreatic cancer therapeutics. Therefore, the purpose of the study was to develop SNEDDS formulation of RESV for therapeutic application in pancreatic cancer therapy. Capryol 90, Cremophor RH, and Transcutol P were selected as the oil, surfactant, and co-surfac...
#1Md. Khalid Anwer (Salman bin Abdulaziz University)H-Index: 15
#2Muzaffar Iqbal (KSU: King Saud University)H-Index: 20
Last. Raisuddin Ali (KSU: King Saud University)H-Index: 10
view all 10 authors...
Abstract In the current study, a novel self-nanoemulsifying drug delivery system (SNEDDS) was developed in order to improve the oral bioavailability of delafloxacin (DLF). Various oils, surfactants and co-surfactants were screened by solubility studies. Based on solubilization, potential of DLF in various vehicles, LauroglycolTM-90 (oil), Tween® 80 (surfactant) and Transcutol®-HP (co-surfactant) were selected for the development of DLF loaded SNEDDS (DLF-SNEDDS). Four formulae of DLF loaded SNED...
1 CitationsSource
#1Saurabh Gupta (Chitkara University)H-Index: 4
#2Arzoo Khan (Chitkara University)H-Index: 1
Last. Rafa Almeer (KSU: King Saud University)H-Index: 15
view all 11 authors...
Huntington disease (HD) is a type of neurodegenerative disease that is characterized by presence of multiple repeats (more than 36) of cytosine-adenine-guanine (CAG) trinucleotides and mutated huntingtin (mHtt). This can further lead to oxidative stress, enhancement in level of ROS/RNS, mitochondrial dysfunction and neuroinflammations. Many clinical and preclinical trials have been conducted so far for the effective treatment of HD however, none of the drugs has shown complete relief. The regene...
#1Rubiya Khursheed (LPU: Lovely Professional University)H-Index: 9
#2Sachin Kumar Singh (LPU: Lovely Professional University)H-Index: 19
Last. Sumana Mondal (LPU: Lovely Professional University)
view all 15 authors...
Abstract Ganoderma lucidium extract powder (GLEP) contains various polysaccharides which are well known for their antioxidant and anti-inflammatory actions. Probiotics (PB) are well-established for providing a plethora of health benefits. Hence, use of mushroom polysaccharides and probiotics as carriers to solidify liquisolid formulation is anticipated to function as functional excipients i.e. as adsorbent that may provide therapeutic benefits. Quercetin (QUR) has been used as model lipophilic d...
#1Rubiya Khursheed (LPU: Lovely Professional University)H-Index: 9
#2Sachin Kumar Singh (LPU: Lovely Professional University)H-Index: 19
Last. K. GowthamarajanH-Index: 7
view all 15 authors...
Introduction: Diabetic neuropathy (DN) is one of the major complications arising from hyperglycaemia in diabetic patients. In recent years polyphenols present in plants have gained attention to tre...
1 CitationsSource
#1Jaskiran Kaur (LPU: Lovely Professional University)H-Index: 3
Last. Navneet Khurana (LPU: Lovely Professional University)H-Index: 7
view all 11 authors...
Abstract Ethnopharmacological relevance Epilepsy is one of the most commonly occurring non-communicable neurological disorder that affects people of all age groups. Around 50 million people globally are epileptic, with 80% cases in developing countries due to lack of access to treatments determined by high cost and poor availability or it can be defined by the fraction of active epileptic patients who are not appropriately being treated. The availability of antiepileptic drugs and their adjuvant...
#1Tithi Roy (ULM: University of Louisiana at Monroe)H-Index: 2
#2Samuel T. Boateng (ULM: University of Louisiana at Monroe)H-Index: 1
Last. Jean Christopher Chamcheu (ULM: University of Louisiana at Monroe)H-Index: 21
view all 17 authors...
Abstract Due to hurdles, including resistance, adverse effects, and poor bioavailability, among others linked with existing therapies, there is an urgent unmet need to devise new, safe, and more effective treatment modalities for skin cancers. Herein, a series of flavonol-based derivatives of fisetin, a plant-based flavonoid identified as an anti- tumorigenic agent targeting the mammalian targets of rapamycin (mTOR)-regulated pathways, were synthesized and fully characterized. N ew potential inh...
2 CitationsSource
#1Rubiya Khursheed (LPU: Lovely Professional University)H-Index: 9
#2Sachin Kumar Singh (LPU: Lovely Professional University)H-Index: 19
Last. Leander Corrie (LPU: Lovely Professional University)H-Index: 5
view all 10 authors...
Abstract Solid self-nanoemulsifying drug delivery system (S-SENDDS) containing Curcumin (CRM) were prepared using combination of Ganoderma lucidium extract powder (GLEP) and probiotics (PB) as carriers. Liquid SNEDDS containing CRM were prepared by mixing Capmul MCM, Labrafil M1944CS, Tween 80 and Transcutol P. These were further spray dried and finally converted into spheroids. The droplet size of reconstituted S-SNEDDS powder and spheroids was found in the range of 35 to 37 nm, zeta potential ...
9 CitationsSource
#1Narendra Kumar Pandey (LPU: Lovely Professional University)H-Index: 9
#2Sachin Kumar Singh (LPU: Lovely Professional University)H-Index: 19
Last. Kamal Dua (UTS: University of Technology, Sydney)H-Index: 28
view all 18 authors...
Abstract Simvastatin (SIM) and glimepiride (GLM) were co-formulated into nanosuspensions and self-nanoemulsifying drug delivery systems (SNEDDS) to improve their dissolution rate and oral bioavailability. Nanosuspension was prepared by liquid anti-solvent precipitation method, involving supersaturation of a solution by mixing the drug solution in an antisolvent. Liquid SNEDDS were prepared by loading drugs into an isotropic mixture of Capmul MCM, Labrafil M1944CS, Tween-80 and Transcutol P. Both...
2 CitationsSource
#1Ankit Kumar (LPU: Lovely Professional University)H-Index: 2
#2Monica Gulati (LPU: Lovely Professional University)H-Index: 23
Last. Rubiya Khursheed (LPU: Lovely Professional University)H-Index: 9
view all 20 authors...
Abstract Oral colon targeted mini-tablets containing 5-Fluorouracil (5-FU) were developed by using guar gum, pectin and Eudragit S100. Probiotics were co-administered to constantly replenish the gut microflora of colon that gets damaged due to pathophysiology of cancer and side effect of 5-FU. Replacement of microbial count ensures that the polysachharide used for sustaining the drug release gets digested to release the drug, once the formulation reaches the colon. The site-specific release of c...
4 CitationsSource