Journal of Drug Delivery Science and Technology
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#1Nitesh Kumar (NITH: National Institute of Technology, Hamirpur)
#2Suhela Tyeb (IITK: Indian Institute of Technology Kanpur)H-Index: 3
Last. Vivek Verma (IITK: Indian Institute of Technology Kanpur)H-Index: 15
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Abstract null null Metal oxide - polymeric (MOP) systems have played a pivotal role in the development of new generation medical technologies focused on targeted therapy and accurate prognosis of specific ailments. Several life threatening and chronic diseases like cancer, tuberculosis, neurodegenerative disorders like Parkinson's and Alzheimer's and those related to cardiovascular systems have seen remarkable intervention of modern tools like magnetic resonance imaging, ultrasound imaging, X-ra...
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#1Seyed Baubak Mostafavi Naeini (Shahid Beheshti University of Medical Sciences and Health Services)
#2Simin Dadashzadeh (Shahid Beheshti University of Medical Sciences and Health Services)H-Index: 23
Last. Melody Vatankhah (Shahid Beheshti University of Medical Sciences and Health Services)
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Abstract null null Cancer is among the most challenging diseases in the world and the number of people who are diagnosed with various cancers is growing every year. Chemotherapy with cytotoxic drugs is one of the main strategies for cancer treatment, however cell cycle-specific drugs, as a wide group of cytotoxic drugs, suffer from having a short plasma half-life. Besides, patients often complain about multiple administration of those drugs to maintain the therapeutic plasma concentration. Multi...
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Abstract null null A novel brimonidine-loaded nanostructured lipid carriers (Br-NLCs)-laden silicone contact lenses were designed for control ocular delivery of brimonidine for effective treatment of glaucoma. The Br-NLCs were found to be spherical in shape with an average size of 100–140 nm and a zeta potential of −31.1–33.7 mV. Compared to conventional soaked contact lenses (Br-SM), Br-NLCs-laden contact lenses improved critical lens properties such as swelling, optical transmittance, and prot...
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#1Qian Qian Zhao (Lanzhou University)
#2Xiaoyun Zhang (Lanzhou University)H-Index: 7
Last. Hua Qiao (Lanzhou University)
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Abstract null null The aims of the study were to prepare oral colon targeted gel beads loaded with isoliquiritigenin (ISL) which exhibited a variety of biological activities with a low solubility and oral bioavailability. ISL loaded sodium alginate and pectin gel beads (SA-P gel beads) were prepared by ionic gel technique, and Uniform Design method was used to optimize the formulation. To decrease the leakage in simulated gastric juice and simulated intestinal juice, the Eudragit S-100, sodium a...
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#1Dazhuang Wang (Liaoning University)
#2Fuyao Luo (Academy of Military Medical Sciences)
Last. Lijiang Chen (Liaoning University)H-Index: 5
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Abstract null null Curcumol is a natural plant product with anti-tumor properties. However, the clinical application of curcumol is limited by its low water solubility. In this study, we synthesized a curcumol derivative 2e (CD-2e) with improved bioavailability and evaluated its cell growth-regulating activities in human hepatoma HepG2 cells, a liver cancer precursor cell line. Using the clone formation assay, we detected that CD-2e inhibits proliferation and activity of HepG2 cells more effecti...
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#1Dipak Kumar Sahu (Siksha O Anusandhan University)H-Index: 2
#2Deepak Pradhan (Siksha O Anusandhan University)H-Index: 3
Last. Goutam Rath (Siksha O Anusandhan University)H-Index: 35
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Abstract null null Dry eye disease (DED) represents a major public health issue worldwide. Conventional ophthalmic preparations usually have a short pre-corneal residence time, require frequent and prolonged administration of drugs, lead to poor medication adherence. Nanocarriers because of their unique structural and functional attributes, display higher rheological synergism, and precorneal residence time results in greater tear film stability and better outcomes than those of conventional for...
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#1Zahra Shariatinia (AUT: Amirkabir University of Technology)H-Index: 36
Abstract null null Traditional drug administration routs suffer from low selective distribution, poor solubility, fast elimination and damaging adjacent healthy tissues (especially in cancer therapy). Thus, drug delivery systems (DDSs) which could deliver drug to target site have broadly been investigated to upsurge the drug bioavailability and to diminish its side effects. Nanocarriers can quickly internalize into cells through intracellular endocytic routes and efficiently release pharmaceutic...
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Organic chemistry
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