Rajan Kumar
Lovely Professional University
Internal medicineBox–Behnken designIntensive care medicineHigh-performance liquid chromatographyBioavailabilityChemistryMaterials scienceFisetinDiseaseDrug deliveryDrugSelf nanoemulsifyingChemical engineeringChromatographyPhase (matter)Traditional medicineMedicineZeta potentialDissolutionPharmacology
32Publications
5H-index
115Citations
Publications 32
Newest
#1Rohit Thakkar (LPU: Lovely Professional University)
#2Rajan Kumar (LPU: Lovely Professional University)H-Index: 5
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Introduction: Herbal plants are known for their anti-oxidant and other various therapeutic activities. Mostly the active chemical moieties of the herbal plants are flavonoids in nature. In the present study, Calotropis procera was evaluated for its anti-oxidant and anti-diabetic activity. Materials and Methods: First the ethanolic extract of leaves of the plant was prepared and then subjected to the in-vitro anti-oxidant and anti-diabetic evaluation. Anti-oxidant activity was evaluated by using ...
#1Mukta Gupta (LPU: Lovely Professional University)H-Index: 3
#2Monica Gulati (LPU: Lovely Professional University)H-Index: 23
Last. N L SinghH-Index: 3
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Abstract Ethnopharmacological relevance Elaeagnus conferta Roxb. (Elaeagnaceae) is a subtropical shrub mainly native to India, Vietnam, Malaysia and South China, whose various parts are used for treatment of diabetes, gastric ulcers, pain, oxidative stress and pulmonary disorders. Though the other parts of the plant have been reported for their ethnic use i.e. fruits as astringent locally and for cancer systemically, leaves for body pain and flowers for pain in chest and the seeds are mentioned ...
1 CitationsSource
#1Rubiya Khursheed (LPU: Lovely Professional University)H-Index: 9
#2Sachin Kumar Singh (LPU: Lovely Professional University)H-Index: 19
Last. K. GowthamarajanH-Index: 7
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Introduction: Diabetic neuropathy (DN) is one of the major complications arising from hyperglycaemia in diabetic patients. In recent years polyphenols present in plants have gained attention to tre...
1 CitationsSource
#1Saurabh Singh (LPU: Lovely Professional University)H-Index: 6
#2Sachin Kumar Singh (LPU: Lovely Professional University)H-Index: 19
Last. Leander CorrieH-Index: 5
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2 CitationsSource
#1Arya Kadukkattil Ramanunny (LPU: Lovely Professional University)H-Index: 3
#2Sheetu Wadhwa (LPU: Lovely Professional University)H-Index: 13
Last. Narendra Kumar Pandey (LPU: Lovely Professional University)H-Index: 9
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Abstract Skin diseases are the fourth leading non-fatal skin conditions that act as a burden and affect the world economy globally. This condition affects the quality of a patient's life and has a pronounced impact on both their physical and mental state. Treatment of these skin conditions with conventional approaches shows a lack of efficacy, long treatment duration, recurrence of conditions, systemic side effects, etc., due to improper drug delivery. However, these pitfalls can be overcome wit...
3 CitationsSource
#1Bhupinder Kapoor (LPU: Lovely Professional University)H-Index: 9
#2Monica Gulati (LPU: Lovely Professional University)H-Index: 23
Last. Som Gupta (Fortis Healthcare)H-Index: 1
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Abstract Aim of the present study was to give a second life to the long-abandoned drug, sulfapyridine (SP) for its anti-arthritic potential by design of nano-vesicular delivery system. For this, intra-articular delivery of its liposomal formulation was tried. As the prepared formulation exhibited rapid drug leakage, an arthritis responsive prodrug of SP showing lability towards synovial enzymes was synthesised to exploit the over-expression of arthritis specific enzymes. Prodrug (SP-PD) exhibite...
1 CitationsSource
#1Ankit Awasthi (LPU: Lovely Professional University)H-Index: 7
#2Sachin Kumar Singh (LPU: Lovely Professional University)H-Index: 19
Last. Ankit Kumar Yadav (LPU: Lovely Professional University)H-Index: 7
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Background Diabetic foot ulcer (DFU) is one of the leading complications of type-2 diabetes mellitus. It isassociated with neuropathy and peripheral arterial disease of the lower limb in patients with diabetes. Basically, there are four stages of wound healing namely hemostasis phase, inflammatory phase, proliferative phase and maturation phase. In case of DFU, all these stages are disturbed which lead to delay in healing and consequently to lower limb amputation. Traditionally the dosage forms ...
Source
#1Rubiya Khursheed (LPU: Lovely Professional University)H-Index: 9
#2Sachin Kumar Singh (LPU: Lovely Professional University)H-Index: 19
Last. Leander Corrie (LPU: Lovely Professional University)H-Index: 5
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Abstract Solid self-nanoemulsifying drug delivery system (S-SENDDS) containing Curcumin (CRM) were prepared using combination of Ganoderma lucidium extract powder (GLEP) and probiotics (PB) as carriers. Liquid SNEDDS containing CRM were prepared by mixing Capmul MCM, Labrafil M1944CS, Tween 80 and Transcutol P. These were further spray dried and finally converted into spheroids. The droplet size of reconstituted S-SNEDDS powder and spheroids was found in the range of 35 to 37 nm, zeta potential ...
9 CitationsSource
#1Narendra Kumar Pandey (LPU: Lovely Professional University)H-Index: 9
#2Sachin Kumar Singh (LPU: Lovely Professional University)H-Index: 19
Last. Kamal Dua (UTS: University of Technology, Sydney)H-Index: 28
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Abstract Simvastatin (SIM) and glimepiride (GLM) were co-formulated into nanosuspensions and self-nanoemulsifying drug delivery systems (SNEDDS) to improve their dissolution rate and oral bioavailability. Nanosuspension was prepared by liquid anti-solvent precipitation method, involving supersaturation of a solution by mixing the drug solution in an antisolvent. Liquid SNEDDS were prepared by loading drugs into an isotropic mixture of Capmul MCM, Labrafil M1944CS, Tween-80 and Transcutol P. Both...
2 CitationsSource
#1Ankit Kumar (LPU: Lovely Professional University)H-Index: 2
#2Monica Gulati (LPU: Lovely Professional University)H-Index: 23
Last. Rubiya Khursheed (LPU: Lovely Professional University)H-Index: 9
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Abstract Oral colon targeted mini-tablets containing 5-Fluorouracil (5-FU) were developed by using guar gum, pectin and Eudragit S100. Probiotics were co-administered to constantly replenish the gut microflora of colon that gets damaged due to pathophysiology of cancer and side effect of 5-FU. Replacement of microbial count ensures that the polysachharide used for sustaining the drug release gets digested to release the drug, once the formulation reaches the colon. The site-specific release of c...
4 CitationsSource