Original paper
Profound degeneration of wake‐promoting neurons in Alzheimer's disease
Abstract
Sleep-wake disturbances are a common and early feature in Alzheimer's disease (AD). The impact of early tau pathology in wake-promoting neurons (WPNs) remains unclear.We performed stereology in postmortem brains from AD individuals and healthy controls to identify quantitative differences in morphological metrics in WPNs. Progressive supranuclear palsy (PSP) and corticobasal degeneration were included as disease-specific controls.The three...
Paper Details
Title
Profound degeneration of wake‐promoting neurons in Alzheimer's disease
Published Date
Aug 12, 2019
Journal
Volume
15
Issue
10
Pages
1253 - 1263
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Notes
History