Jun Oh
University of California, Berkeley
Sleep in non-human animalsPsychiatryNeuropsychiatryNeuroscienceProgressive supranuclear palsyCorticobasal degenerationStereologySleep deprivationLocus coeruleusReticular formationDepression (differential diagnoses)Braak stagingDiseaseWakefulnessDegeneration (medical)DementiaAutopsyNeurofibrillary tangleNeuropathologyNucleusHypothalamic nucleusArousalAlzheimer's diseaseBrainstemAnxietyPostmortem studiesMedicineBiology
6Publications
3H-index
117Citations
Publications 4
Newest
#1Jun Oh (University of California, Berkeley)H-Index: 3
#2Rana Eser (University of California, Berkeley)H-Index: 5
Last. Lea T. GrinbergH-Index: 62
view all 19 authors...
Abstract Introduction Sleep-wake disturbances are a common and early feature in Alzheimer's disease (AD). The impact of early tau pathology in wake-promoting neurons (WPNs) remains unclear. Methods We performed stereology in postmortem brains from AD individuals and healthy controls to identify quantitative differences in morphological metrics in WPNs. Progressive supranuclear palsy (PSP) and corticobasal degeneration were included as disease-specific controls. Results The three nuclei studied a...
23 CitationsSource
#1Jun Oh (University of California, Berkeley)H-Index: 3
#2Rana Eser (University of California, Berkeley)H-Index: 5
Last. Lea T. Grinberg (USP: University of São Paulo)H-Index: 62
view all 15 authors...
Source
#1Rana Eser (UCSF: University of California, San Francisco)H-Index: 5
#2Alexander J. Ehrenberg (UCSF: University of California, San Francisco)H-Index: 11
Last. Lea T. Grinberg (UCSF: University of California, San Francisco)H-Index: 62
view all 15 authors...
: The brainstem nuclei of the reticular formation (RF) are critical for regulating homeostasis, behavior, and cognition. RF degenerates in tauopathies including Alzheimer disease (AD), progressive supranuclear palsy (PSP), and corticobasal degeneration (CBD). Although the burden of phopho-tau inclusion is high across these diseases, suggesting a similar vulnerability pattern, a distinct RF-associated clinical phenotype in these diseases indicates the opposite. To compare patterns of RF selective...
16 CitationsSource
#1Alexander J. Ehrenberg (University of California, Berkeley)H-Index: 11
#2Claudia K. Suemoto (USP: University of São Paulo)H-Index: 22
Last. Lea T. Grinberg (USP: University of São Paulo)H-Index: 62
view all 15 authors...
: Clarifying the relationships between neuropsychiatric symptoms and Alzheimer's disease (AD)-related pathology may open avenues for effective treatments. Here, we investigate the odds of developing neuropsychiatric symptoms across increasing burdens of neurofibrillary tangle and amyloid-β pathology. Participants who passed away between 2004 and 2014 underwent comprehensive neuropathologic evaluation at the Biobank for Aging Studies from the Faculty of Medicine at the University of Sao Paulo. Po...
46 CitationsSource