Targeted Therapy of Uveal Melanoma: Recent Failures and New Perspectives
Abstract
Among Uveal Melanoma (UM) driver mutations, those involving GNAQ or GNA11 genes are the most frequent, while a minor fraction of tumors bears mutations in the PLCB4 or CYSLTR2 genes. Direct inhibition of constitutively active oncoproteins deriving from these mutations is still in its infancy in UM, whereas BRAFV600E-targeted therapy has obtained relevant results in cutaneous melanoma. However, UM driver mutations converge on common downstream...
Paper Details
Title
Targeted Therapy of Uveal Melanoma: Recent Failures and New Perspectives
Published Date
Jun 18, 2019
Journal
Volume
11
Issue
6
Pages
846 - 846
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