In vitro and in vivo evaluation of a novel mitomycin nanomicelle delivery system
Abstract
Mitomycin C (MMC), naturally synthesized by Streptomyces caespitosus, is a potent antineoplastic antibiotic for the treatment of various solid tumors. However, the defects of conventional MMC injections have greatly limited its clinical application due to its toxic side effects and non-specific interactions. To solve this problem, the PEG2k-Fmoc-Ibuprofen (PEG-FIbu) micellar nanocarrier was synthesized and the MMC-loaded micelles (PEG-FIbu/MMC)...
Paper Details
Title
In vitro and in vivo evaluation of a novel mitomycin nanomicelle delivery system
Published Date
Jan 1, 2019
Journal
Volume
9
Issue
26
Pages
14708 - 14717
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