Min Zhao
Shenyang Pharmaceutical University
Therapeutic effectPharmacokineticsMass spectrometryFourier transform ion cyclotron resonanceHigh-performance liquid chromatographyBioavailabilityChemistryDecoctionMetabolic pathwayIn vivoMetabolomicsFormic acidAtorvastatinGynostemma pentaphyllumFatty liverHyperlipidemiaChromatographyLipid metabolismProtein precipitationPharmacology
27Publications
8H-index
154Citations
Publications 26
Newest
#1Yumeng Zhang (SPU: Shenyang Pharmaceutical University)H-Index: 3
#2Min Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 8
Last. Miao Wang (SPU: Shenyang Pharmaceutical University)H-Index: 8
view all 6 authors...
Hepatic fibrosis (HF) is a typical consequence of various chronic liver diseases, and there is still no ideal drug for its treatment. Yinchen Wuling Powder (YCWLP), a famous traditional Chinese medicine prescription, is effective for the treatment of icteric hepatitis, hepatic fibrosis, non-alcoholic fatty liver disease and other liver diseases in clinical practices, however, the underlying mechanisms of YCWLP on HF is still unclear. In this study, 1H NMR and MS-based metabolomics analysis along...
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#1Xu Yan (SPU: Shenyang Pharmaceutical University)H-Index: 1
#2Min Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 8
Last. Chunjie Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 6
view all 7 authors...
Knoxiae Radix (HDJ, usually used after being processed into CHDJ) is a traditional Chinese herbal medicine that has been recorded in the Chinese Pharmacopoeia for years. It is said that Glycyrrhizae Radix et Rhizoma (GC) is incompatible with HDJ, but few studies can prove this. In this work, non-targeted metabolomics experiments were performed on rats to evaluate the effect of the combination of the two herbals. For this, we conducted a 28-day administration in rats. The plasma, urine and kidney...
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#1Yumeng Zhang (SPU: Shenyang Pharmaceutical University)H-Index: 3
#2Min Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 8
Last. Miao Wang (SPU: Shenyang Pharmaceutical University)H-Index: 8
view all 6 authors...
Abstract Yinchen Wuling Powder (YCWLP) is a classic Chinese medicine prescription with a long history and has been commonly used for treating jaundice hepatitis, liver fibrosis, hyperlipidemia and early diabetes in clinical applications. However, the chemical composition of YCWLP is still unclear. In order to obtain the chemical profile of YCWLP, a systematic ultra-performance liquid chromatography coupled with fourier transform ion cyclotron resonance mass spectrometry (UPLC-FT-ICR-MS) method w...
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#1Tingting Liu (SPU: Shenyang Pharmaceutical University)
#2Min Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 8
Last. Miao Wang (SPU: Shenyang Pharmaceutical University)H-Index: 8
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Clinically, Wangbi Capsule (WBC) is widely used in the treatment of Rheumatoid arthritis (RA) because of its remarkable therapeutic effect. To reveal the mechanism, a pharmacokinetic-pharmacodynamic (PK-PD) model was developed for the first time to assess the relationship between time-concentration (dose)-effect. Freund's Complete Adjuvant (FCA) was used to induce the Adjuvant-Induced Arthritis (AIA) model. Multi-index were used to evaluate the therapeutic effect and a S-Imax PK-PD model was est...
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#1Jingwei Li (SPU: Shenyang Pharmaceutical University)
#2Miao Wang (SPU: Shenyang Pharmaceutical University)H-Index: 8
Last. Min Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 8
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Duzhong Jiangya Tablet is a hypotensive drug. In this study, High-performance liquid chromatography-fourier transform-ion cyclotron resonance-mass spectrometry technology was used to quickly identify its chemical composition. SinoChrom ODS-BP column (250mm×4.6mm, 5μm) was used. The mobile phase was acetonitrile(A)-0.1% formic acid solution(B). The flow rate was 1 mL·min-1 . Extracted ion chromatogram was used to analyze the samples in positive and negative ion modes. Based on the obtained accura...
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#1Lin Sun (SPU: Shenyang Pharmaceutical University)
#2Min Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 8
Last. Chunjie Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 6
view all 7 authors...
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#1Yanhui Zhao (SPU: Shenyang Pharmaceutical University)
#2Miao Wang (SPU: Shenyang Pharmaceutical University)H-Index: 8
Last. Chunjie Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 6
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Sanhua decoction, a famous Chinese herbal formula has been widely used for the treatment of stroke. In our study, a rapid, swift and straightforward analytical method with the help of UHPLC-FT-ICR-MS/MS was successfully developed for the first time to separate and identify the chemical constituents of Sanhua decoction. Chromatography was performed on a Universal XB C18 column (150 mm × 2.1 mm, 1.8 μm) using a mobile phase containing 0.1% formic acid–water (A) and acetonitrile (B). A total of 137...
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#1Lin Sun (SPU: Shenyang Pharmaceutical University)
#2Min Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 8
Last. Chunjie Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 6
view all 6 authors...
Shaoyao Gancao decoction (SGD) is a famous Chinese traditional prescription for treating liver injury. In this research, we investigated the liver protective effects of SGD and its metabolic mechanisms by 1 H-NMR and UPLC-MS. Serum biochemical indicators and histopathological methods werae used to identify the status of SGD in treating liver injury. An OPLS-DA method was used to screen potential differential metabolic markers, and the MetaboAnalyst and KEGG PATHWAY databases were used to find re...
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#1Jingwei Li (SPU: Shenyang Pharmaceutical University)
#2Min Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 8
Last. Chunjie Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 6
view all 6 authors...
Duzhong Jiangya Tablet (DJT) composed of Eucommia ulmoides Oliv. and several other traditional Chinese medicines is a Chinese herbal compound, which is clinically used to treat hypertension. The aim of this study was to evaluate the antihypertensive effect of DJT and amlodipine besylate (AB) on the synergistic treatment of spontaneously hypertensive rats (SHRs), and to explore its antihypertensive mechanism. The synergistic therapeutic effect of DJT in combination with AB on SHR was studied usin...
1 CitationsSource
#1Yi CaiH-Index: 2
#2Min ZhaoH-Index: 8
Last. Chunjie ZhaoH-Index: 6
view all 6 authors...
: Semen descurainiae oil (SDO) is an important traditional Chinese medicine that was recently discovered to have the function of reducing blood lipids. Metabolomics analyses of plasma, liver and kidney in rats were performed using 1 H-NMR and LC-MS to illuminate the lower blood lipid concentration effect of SDO, and niacin was considered as the active control. The measure of total cholesterol (TC) and low-density-lipoprotein cholesterol (LDL-C) in plasma showed that SDO treatment decreased signi...
1 CitationsSource