Role of prostaglandin I2 in the bronchoconstriction-triggered cough response in guinea pigs
Abstract
Purpose/Aim of the study: Methacholine chloride (MCh) inhalation causes bronchoconstriction and cough. Following MCh-induced bronchoconstriction, metabolic products of prostaglandin I2 (PGI2) increase in bronchoalveolar lavage fluid (BALF), suggesting that PGI2 plays a role in the cough response. Accordingly, we used an experimental guinea pig model to evaluate the role of PGI2 in the bronchoconstriction-triggered cough response.Experiment 1:...
Paper Details
Title
Role of prostaglandin I2 in the bronchoconstriction-triggered cough response in guinea pigs
Published Date
Nov 26, 2018
Journal
Volume
44
Issue
10
Pages
455 - 463
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