Shinji Nakao
Kanazawa University
HaematopoiesisInternal medicineSurgeryPathologyOncologyMolecular biologyHuman leukocyte antigenHematologyImmunologyAnemiaLeukemiaBone marrowBone marrow failureAplastic anemiaStem cellTransplantationCancer researchMedicineBiologyGastroenterology
599Publications
59H-index
7,995Citations
Publications 607
Newest
#1Kohei Hosokawa (Kanazawa University)H-Index: 12
#2Ken Ishiyama (Kanazawa University)H-Index: 18
Last. Shinji Nakao (Kanazawa University)H-Index: 59
view all 19 authors...
Small populations of glycosylphosphatidylinositol-anchored protein-deficient (GPI[-]) cells accounting for up to 0.01% of total granulocytes can be accurately detected by a high-sensitivity flow cytometry (FCM) assay established by the Clinical and Laboratory Standards Institute (CLSI method) and have a prognostic value in bone marrow failure (BMF); however, the significance of GPI(-) granulocytes accounting for 0.001-0.009% of granulocytes remains unclear. To clarify this issue, we examined the...
2 CitationsSource
#1Takeshi Yamashita (Kanazawa University)H-Index: 6
#2Hiroyuki Takamatsu (Kanazawa University)H-Index: 20
view all 23 authors...
This nationwide multicentre retrospective study was performed to analyze clinical features that predict the prognosis of central nervous system invasion in multiple myeloma (CNS-MM, approximately 1% of MM). Overall, of the 77 adult patients with CNS-MM identified between 2005 and 2016, those diagnosed at MM diagnosis (n = 3) had longer overall survival (OS) than those diagnosed at relapse (n = 74; median: 48·5 vs 2·7 months). Therefore, we compared the relapsed MM with CNS-MM in patients with an...
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#1Kohei Hosokawa (Kanazawa University)H-Index: 12
#2Hiroki Mizumaki (Kanazawa University)H-Index: 1
Last. Shinji Nakao (Kanazawa University)H-Index: 59
view all 20 authors...
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#1Takeshi Yoroidaka (Kanazawa University)H-Index: 2
#2Kentaro NaritaH-Index: 8
Last. Kosei MatsueH-Index: 25
view all 6 authors...
In this study, the minimal residual disease (MRD) levels in patients with multiple myeloma (MM) were assessed by comparing the new 8-color single-tube multiparameter flow cytometry method (DuraClone), which reduces the cost of antibodies and labor burden of laboratories, with the EuroFlow next-generation flow (NGF) method. A total of 96 samples derived from 69 patients with MM were assessed to determine the total cell acquisition number (tCAN), percentages of total and normal plasma cells (PCs),...
1 CitationsSource
#1Hiroyuki TakamatsuH-Index: 20
#2Shinya YamadaH-Index: 3
Last. Shinji NakaoH-Index: 59
view all 12 authors...
IVIG is occasionally used for preventing and treating severe infections of patients who are to undergo transplantation. Administration of IVIG, which includes high-titer antibodies (Abs) against HLA class I and II, might have a substantial influence on the HLA Ab test results of these patients. However, this issue has remained unreported. Methods Anti-HLA Ab titers were determined in 4 types of IVIG preparations, fresh frozen plasma, and the sera of 11 patients with hematological diseases before...
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#1Atsushi Narita (Nagoya University)H-Index: 15
#2Hideki Muramatsu (Nagoya University)H-Index: 38
Last. Yoshiyuki Takahashi (Nagoya University)H-Index: 42
view all 14 authors...
Objectives Patients with acquired aplastic anemia (AA) without HLA-matched sibling donors or aged >40 years receive immunosuppressive therapy (IST) with anti-thymocyte globulin (ATG). We investigated the relationship between plasma rabbit ATG (r-ATG) concentration and IST response. Methods From May 2012 to October 2017, 81 patients with severe AA who required initial IST were included. A 1:1 block randomization was employed for 2.5 and 3.5 mg/kg doses of r-ATG. Results No significant difference ...
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#1Kohei Hosokawa (Kanazawa University)H-Index: 12
#2Shinji Nakao (Kanazawa University)H-Index: 59
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#1Kazunori ImadaH-Index: 23
#2Naoshi Obara (University of Tsukuba)H-Index: 19
Last. Shinji Nakao (Kanazawa University)H-Index: 59
view all 12 authors...
Objective In Japan, immunosuppressive therapy (IST) with anti-thymocyte globulin (ATG), and cyclosporine A (CsA) is the standard of care in patients with aplastic anemia (AA) who are not indicated for stem-cell transplantation, although some patients may experience relapse. This study assessed the efficacy and safety of eltrombopag in combination with rabbit-ATG/CsA in IST-naive patients with non-severe or severe AA in Japan. Methods In this non-randomized, open-label, single-arm, phase II study...
1 CitationsSource
#1Takeshi Yoroidaka (Kanazawa University)H-Index: 2
#2Kohei Hosokawa (Kanazawa University)H-Index: 12
Last. Shinji Nakao (Kanazawa University)H-Index: 59
view all 11 authors...
To characterize glycosylphosphatidylinositol-anchored protein-deficient (GPI[-]) and HLA-class I allele-lacking (HLA[-]) hematopoietic stem progenitor cells (HSPCs) in acquired aplastic anemia (AA), we studied the peripheral blood (PB) of 56 AA patients in remission who possessed both (n = 13, Group A) or either GPI(-) (n = 34, Group B) and HLA(-) (n = 9, Group C) cell populations. Seventy-seven percent (10/13) of Group A had HLA(-) cells in all lineages of PB cells, including platelets, while o...
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