Experimental Lung Research
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1969
Papers 2009
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#1Tina Schreiber (CAU: University of Kiel)H-Index: 1
#2Maren Falk-Paulsen (CAU: University of Kiel)H-Index: 7
Last. Burkhard Bewig (CAU: University of Kiel)H-Index: 16
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PURPOSE OF THE STUDY The involvement of the IL-23/IL23R pathway is well known in the disease pathogenesis of sarcoidosis and other inflammatory diseases. To date, the pathogenic mechanism of IL-23 is most notably described on CD4+ Th17 lymphocytes. However, the function of the IL23R on myeloid cells in sarcoidosis is poorly understood. Thus, the aim of the study is to investigate the role of the IL23R on myeloid cell in pulmonary granuloma formation. Methods: We generated IL23RLysMCre mice lacki...
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#1Nikolett Király (University of Debrecen)H-Index: 2
#2Csilla Csortos (University of Debrecen)H-Index: 16
Last. Anita Boratkó (University of Debrecen)H-Index: 8
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PURPOSE/AIM TIMAP (TGF-β-inhibited membrane-associated protein) is a regulatory subunit of protein phosphatase 1 (PP1). The N-terminal region contains a binding motif for the catalytic subunit of PP1 (PP1c) and a nuclear localization signal (NLS). Phosphorylation of TIMAP on Ser331, Ser333 and Ser337 side chains was shown to regulate the activity of the TIMAP-PP1c complex. Several studies, however, reported an additional side chain of TIMAP. Ser69 is located near to the PP1c binding motif and NL...
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#1Jing-Chao Su (Anhui University of Chinese Medicine)
#2Yi Zhang (Anhui University of Chinese Medicine)
Last. Xin-fang Zhang (Anhui University of Chinese Medicine)H-Index: 3
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OBJECTIVE Chronic obstructive pulmonary disease (COPD) is a respiratory disease with high morbidity and mortality worldwide, so far there is no ideal treatment method. Previous studies have shown that hydrogen (H2) is involved in the treatment of COPD as an antioxidant. In this study, the effect of H2 on M1/M2 polarization of alveolar macrophages in COPD rats was observed, and its anti-inflammatory mechanism was further elucidated. Methods: Twenty-four Sprague-Dawley rats were randomly divided i...
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#1Ulf P. Arborelius (KI: Karolinska Institutet)H-Index: 18
#2David Rocksén (KI: Karolinska Institutet)H-Index: 3
Last. Mattias Günther (KI: Karolinska Institutet)H-Index: 6
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Purpose. Behind armor blunt trauma (BABT) is a non-penetrating injury caused by the rapid deformation of body armor, by a projectile, which may in extreme circumstances cause death. The understanding of the mechanisms is still low, in relation to what is needed for safety threshold levels. High velocity projectile BABT causes immediate and severe hypoxia by increased venous admixture (Q's/Q't), but it is not known whether the level of hypoxia correlates to the kinetic energy (Ek) of the projecti...
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BACKGROUND: Circular RNAs (circRNAs) have been implicated in the molecular etiology of pediatric pneumonia. Here, we investigated the precise action of circRNA tropomodulin 3 (circTMOD3, hsa_circ_0035292) in cell injury and inflammation induced by lipopolysaccharide (LPS). Methods: Cell viability was gauged by Cell Counting Kit-8 (CCK-8) assay. Cell apoptosis and cycle distribution were assessed by flow cytometry. Enzyme-linked immunosorbent assay (ELISA) was used to measure interleukin-6 (IL-6)...
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#1Zhen He (Lanzhou University)
#2Jirong Wu (Lanzhou University)
Last. Xiaoju Liu (Lanzhou University)H-Index: 5
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Purpose null Asthma is associated with a T helper (Th)17/regulatory T (Treg) cells immune imbalance where the Notch signaling pathway contributes vitally. This study aimed to explore the role of Notch ligands Jagged1 and Delta4 in the Th17/Treg immune imbalance of chronic asthmatic mice. null Methods null The experimental animals were randomly assigned to the Saline, ovalbumin (OVA), and OVA + γ-secretase inhibitor (GSI) groups. A mouse model of chronic asthma was induced by OVA sensitization an...
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#1Yi-Wei Yang (UCSF: University of California, San Francisco)H-Index: 3
#2David M. Jablons (UCSF: University of California, San Francisco)H-Index: 72
Last. Hassan Lemjabbar-Alaoui (UCSF: University of California, San Francisco)H-Index: 9
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PURPOSE Non-small lung (NSCLC) is the deadliest cancer, with survival measured in months. Earlier diagnosis using a robust biomarker would likely improve survival. This study aims to determine whether blood levels of the extracellular sulfatases (SULF1 and SULF2) and their bio-activity can serve as novel biomarkers for NSCLC early detection. MATERIALS AND METHODS Using human plasma specimens from NSCLC patients, nonmalignant COPD patients, and healthy individuals, we determined the association b...
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#1X Zhang (North China University of Science and Technology)H-Index: 1
#2Zhang Z (North China University of Science and Technology)H-Index: 1
Last. Fuhai Shen (North China University of Science and Technology)H-Index: 2
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OBJECTIVES The purpose of this study was to analyze the α-SiO2 content, composition, dispersion, morphology, and free radical content of dust between the alveolar and the workplace, to explore the possible changes in the properties (especially the pathogenicity) of dust after it enters the lung. METHODS We collected the dust in the workplace in HANDAN Coal mine. They were selected by a 400 mesh sieve and was made a suspension of 50 mg/ml, which would be used to perfuse into the trachea of rats. ...
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#1Ling Ma (XMU: Xinjiang Medical University)
#2Li Shan (XMU: Xinjiang Medical University)
Purpose: To delve into the related molecular mechanism of ACTL6A on non-small cell lung cancer (NSCLC) cell growth and apoptosis.Methods: Quantitative real-time polymerase chain reaction, immunohistochemical staining, and western blot assays were employed to examine ACTL6A mRNA and protein expression in four NSCLC cell line (NCI-H2170, LTEP-s, NCI-H1703, and PC-9) and normal lung cell line (BEAS-2B). CCK-8 cell viability assays and clone formation assay were applied to verify the cell proliferat...
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#1Tatsuya Hosono (Jichi Medical University)H-Index: 8
#2Masashi Bando (Jichi Medical University)H-Index: 22
Last. Yukihiko SugiyamaH-Index: 43
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Background and objectives Idiopathic pulmonary fibrosis (IPF) is a progressive and lethal lung disease. An increased expression of somatostatin receptor subtype 2 in patients with IPF was identified and lung fibroblasts expressed somatostatin receptors in vitro. In addition, somatostatin analogue inhibits the expression of transforming growth factor-β, insulin-like growth factor (IGF) -1, platelet-derived growth factor, and basic fibroblast growth factor. Therefore, we examined the effects of so...
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