Dosimetry of ¹⁷⁷Lu-PSMA-617 in Metastatic Castration-Resistant Prostate Cancer: Correlations Between Pretherapeutic Imaging and Whole-Body Tumor Dosimetry with Treatment Outcomes

¹⁷⁷Lu-prostate-specific membrane antigen (PSMA)–617 enables targeted delivery of β-particle radiation to prostate cancer. We determined its radiation dosimetry and relationships to pretherapeutic imaging and outcomes. Methods: Thirty patients with prostate cancer receiving ¹⁷⁷Lu-PSMA-617 within a prospective clinical trial (ACTRN12615000912583) were studied. Screening ⁶⁸Ga-PSMA-11 PET/CT demonstrated high...