#2Carlos Artigas(ULB: Université Libre de Bruxelles)H-Index: 12
Last. Patrick Flamen(ULB: Université Libre de Bruxelles)H-Index: 41
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Aim: We aimed to evaluate the role of Positron Emission Tomography (PET) targeting the Prostate-Specific Membrane Antigen (PSMA) for response assessment in metastatic prostate cancer (mPCa) patients treated with taxane-based chemotherapy (docetaxel or cabazitaxel) and its predictive value on patient outcome. Methods: We retrospectively evaluated 37 patients with metastatic hormone-sensitive or castration-resistant prostate cancer (mHSPC or mCRPC) who underwent 68Ga-PSMA-11 PET/CT at baseline and...
Last. James O. Park(UW: University of Washington)H-Index: 20
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Hepatocellular carcinoma (HCC) is a significant cause of morbidity and mortality worldwide with limited therapeutic options for advanced disease. Targeted alpha therapy (TAT) is an emerging class of targeted cancer therapy in which alpha-particle-emitting radionuclides, such as thorium-227, are specifically delivered to cancer tissue. null Glypican-3 (GPC3) is a cell surface glycoprotein highly expressed on HCC. null In this study, we describe the development and in vivo efficacy of a 227Th-labe...
Radiation pneumonitis is a rare but possibly fatal side effect of Yttrium-90 (90Y) radioembolization. It may occur 1 to 6 months after therapy, in case a significant part of the 90Y microspheres shunt to the lungs. In current clinical practice, a predicted value of lung dose greater than 30Gy is considered a criterion to exclude patients from treatment. However, contrasting findings regarding the occurrence of radiation pneumonitis and lung dose were previously reported in literature. In this st...
Background: A subset (35%) of triple negative breast cancers (TNBC) express androgen receptor (AR) activity. However, clinical trials with anti-androgen drugs have shown limited efficacy with about a 19% clinical benefit rate. We investigate the therapeutic enhancement of anti-androgens as radiosensitizers in combination with 18F-fluoro-2-deoxy-D-glucose (18F-FDG) in TNBC. Methods: We screened five candidate drugs to evaluate shared toxicity when combined with either 18F-FDG, X-ray or ultraviole...
#1Ryan Reddy(MSK: Memorial Sloan Kettering Cancer Center)H-Index: 1
#2C. Ross Schmidtlein(MSK: Memorial Sloan Kettering Cancer Center)H-Index: 15
Last. Lisa Bodei(MSK: Memorial Sloan Kettering Cancer Center)H-Index: 25
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Rationale: 68Ga-labelled somatostatin analog PET/CT (SSA PET/CT) is now standard of care component in management of neuroendocrine tumors (NETs). However, treatment response for NETs is still performed with morphologic size measurements from other modalities, which can result in inaccurate disease burden. Functional tumor volume (FTV) acquired from SSA PET/CT has been suggested as a possible metric, but no validated measurement tool to measure FTV exists. We tested the precision of multiple FTV ...
Last. Irène Buvat(University of Paris-Saclay)H-Index: 47
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The nuclear medicine field has seen a rapid expansion of academic and commercial interests in developing artificial intelligence (AI) algorithms. Users and developers can avoid some of the pitfalls of AI by recognizing and following best practices in AI algorithm development. In this article, recommendations for technical best practices for developing AI algorithms in nuclear medicine are provided, beginning with general recommendations followed by descriptions on how one might practice these pr...
Last. Deandreis D(UNITO: University of Turin)H-Index: 11
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Aim: To evaluate the prognostic value of somatostatin receptor tumor burden (SRTB) at 68Ga-DOTATOC positron emission tomography/computed tomography (PET/CT) in patients with well-differentiated neuroendocrine tumors (WD-NETs). Methods: We retrospectively analyzed 68Ga-DOTATOC-PET/CT of 84 patients with histologically confirmed WD-NETs (51 G1, 30 G2 and 3 G3). For each PET/CT, all DOTATOC-avid lesions were independently segmented by 2 operators using a customized threshold based on the healthy li...
#1Christine E. Mona(UCLA: University of California, Los Angeles)H-Index: 7
#2Matthias R. Benz(UCLA: University of California, Los Angeles)H-Index: 24
Last. Jeremie Calais(UCLA: University of California, Los Angeles)H-Index: 23
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Purpose: Fibroblast activation protein (FAP)-expressing cancer-associated fibroblasts confer treatment resistance, promote metastasis and immunosuppression. Because FAP is overexpressed in many cancers, radiolabeled molecules targeting FAP are studied for their use as pan-cancer theranostic agents. This study aims to establish the spectrum of FAP expression across various cancers by immunohistochemistry and to explore whether gallium-68 FAPi-46 (68Ga-FAPi-46) PET biodistribution faithfully refle...
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