The Journal of Nuclear Medicine
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#1Juliano Julio CerciH-Index: 15
#2Stefano Fanti (UNIBO: University of Bologna)H-Index: 83
Last. Rakesh Kumar (AIIMS: All India Institute of Medical Sciences)H-Index: 73
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Biochemical recurrence (BCR) is a clinical challenge in prostate cancer (PCa) patients as recurrence localization guides subsequent therapies. The use of positron emission tomography (PET) with prostate-specific membrane antigen (PSMA) presents better accuracy than standard imaging practice. This prospective, multicenter, international study evaluates the diagnostic performance and clinical impact of PSMA-PET/CT in evaluating BCR in Pca in a worldwide scenario. Methods: Patients were recruited f...
#1Irene Virgolini (University of Innsbruck)H-Index: 5
#2Shadfar Bahri (UCLA: University of California, Los Angeles)H-Index: 13
Last. Christine Powell (Ipsen)
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68Ga-satoreotide trizoxetan is a novel somatostatin receptor antagonist associated with high sensitivity and reproducibility in neuroendocrine tumour (NET) detection and localisation. However, the optimal peptide mass and radioactivity ranges for 68Ga-satoreotide trizoxetan have not yet been established. We therefore aimed to determine its optimal dosing regimen in patients with metastatic gastroenteropancreatic NETs in a prospective, randomised, 2×3 factorial, multicentre, phase II study. Metho...
Purpose: Plastics are used commonly in the world because of its convenience and cost-effectiveness. Microplastics, an environmental threat and human health risk, are widely detected in food, and consequently ingested. However degraded plastics are found everywhere, which cause environmental threat and human health risk. Therefore, real-time monitoring of orally administered microplastics is tremendously important to trace them in the body. Methods: In this study, to visualize their absorption pa...
#1Marti Boss (Radboud University Nijmegen)H-Index: 5
#2Christof Rottenburger (University Hospital of Basel)H-Index: 8
Last. Pirjo Nuutila (UTU: University of Turku)H-Index: 87
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Surgery with curative intent can be offered to Congenital Hyperinsulinism (CHI) patients, provided that the lesion is focal. Radiolabeled Exendin-4 specifically binds the glucagon-like peptide 1 receptor (GLP-1R) on pancreatic beta cells. In this study we compared the performance of [18F]F-DOPA positron emission tomography/computed tomography (DOPA PET) and PET/CT with the new tracer [68Ga]Ga-NODAGA-exendin-4 (Exendin PET) in the preoperative detection of focal CHI. Methods: Nineteen CHI patient...
Fibroblast activation protein (FAP) is a promising target for diagnosis and therapy of numerous malignant tumors. FAP-2286 is the conjugate of a FAP-binding peptide, which can be labeled with radionuclides for theranostic applications. We present the first-in-human results using 177Lu-FAP-2286 for peptide-targeted radionuclide therapy (PTRT). Methods: PTRT using 177Lu-FAP-2286 was performed in 11 patients with advanced adenocarcinomas of pancreas, breast, rectum and ovary after prior confirmatio...
#1Alton O. Sartor (Tulane University)H-Index: 3
Last. Avivit PeerH-Index: 14
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We analyzed real-world clinical outcomes of sequential alpha-/beta-emitter therapy for metastatic castration-resistant prostate cancer (mCRPC). Methods: We assessed safety and overall survival in 26 patients who received lutetium-177–prostate-specific membrane antigen ligand (177Lu-PSMA) following radium-223 in the ongoing non-interventional Radium-223 alpha Emitter Agent Safety Study in mCRPC popUlation for long-teRm Evaluation (REASSURE; NCT02141438). Results: Patients received radium-223 for ...
#1Cristina Barca (European Institute)H-Index: 3
#2Amanda J. Kiliaan (Radboud University Nijmegen)H-Index: 35
Last. Bastian Zinnhardt (European Institute)H-Index: 10
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Microglia-induced neuroinflammation after stroke contributes to the exacerbation of post-ischemic damage but also supports neurorestorative events. Longitudinal molecular imaging of microglia-targeted therapies will support the assessment of target engagement, therapy efficacy, and deciphering the mode of action. We investigated the effects of chronic colony stimulating factor-1 receptor (CSF-1R) inhibitor-mediated microglia depletion on translocator protein (TSPO)-dependent neuroinflammation an...
#1Johannes Czernin (UCLA: University of California, Los Angeles)H-Index: 94
#2Jeremie Calais (UCLA: University of California, Los Angeles)H-Index: 20
#1Cristina Gamila Wakfie-Corieh (Hospital Clínico San Carlos)H-Index: 2
Last. José Luis Carreras Delgado (Hospital Clínico San Carlos)H-Index: 5
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Although the novel coronavirus disease 2019 (COVID-19) can present as non-specific clinical forms, subclinical cases represent an important route of transmission and a significant source of mortality, mainly in high-risk subpopulations such as cancer patients. A deeper knowledge about the shift in cellular metabolism of Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infected cells could provide new insights about its pathogenic and host response and help to diagnose pulmonary invol...
#1Michael Mix (University of Freiburg)H-Index: 25
#2Tobias Renaud (University of Freiburg)
Last. Juri Ruf (University of Freiburg)H-Index: 15
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The radiation dose to the kidneys should be monitored in prostate cancer patients treated with radioligand therapy (RLT) targeting the prostate-specific membrane antigen (PSMA). We analyzed whether pretherapeutic kidney function is predictive of subsequent kidney dose and to what extend the cumulative kidney dose after multiple therapy cycles at the end of treatment can be predicted from a dosimetry based on the first cycle. Methods: Data of 59 patients treated with at least 2 cycles of 177Lu-PS...
Top fields of study
Nuclear medicine