Errors in protein synthesis increase the level of saturated fatty acids and affect the overall lipid profiles of yeast
Abstract
The occurrence of protein synthesis errors (mistranslation) above the typical mean mistranslation level of 10-4 is mostly deleterious to yeast, zebrafish and mammal cells. Previous yeast studies have shown that mistranslation affects fitness and deregulates genes related to lipid metabolism, but there is no experimental proof that such errors alter yeast lipid profiles. We engineered yeast strains to misincorporate serine at alanine and glycine...
Paper Details
Title
Errors in protein synthesis increase the level of saturated fatty acids and affect the overall lipid profiles of yeast
Published Date
Aug 27, 2018
Journal
Volume
13
Issue
8
Pages
e0202402 - e0202402
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