Neurotensin, substance P, and insulin enhance cell migration

Neurotensin, substance P, and insulin have been demonstrated to improve wound healing in vivo . However, the mechanism behind their effect is still not fully understood. This study investigates the effects leading to enhanced scratch closure by these peptides in vitro . The skin keratinocyte cell line, HaCaT, was used to test scratch closure effects of the peptides and alterations of cytokine levels. HUVEC cells were used to test the angiogenic...