Journal of Peptide Science
Papers 2511
1 page of 252 pages (2,511 results)
#1Anzhelika O Fedotova (MSU: Moscow State University)
#2B. V. Egorova (MSU: Moscow State University)H-Index: 5
Last. Stepan N. Kalmykov (Kurchatov Institute)H-Index: 21
view all 8 authors...
Somatostatin analogues play an important role in the therapy of neuroendocrine tumors by binding to somatostatin receptors on the surface of cancer cells. In this work, we analyze the receptor-binding affinity and in vitro stability of a novel ultra-short somatostatin analogue Thz-Phe-D-Trp-Lys-Thr-DOTA (DOTA-P4). This conjugate is successfully radiolabeled with 44 Sc, 90 Y, 152 Eu, and 207 Bi, characterized and validated by thin layer and high-performance liquid chromatography. The optimum cond...
#1Hidetomo YokooH-Index: 2
#2Motoharu Hirano (YCU: Yokohama City University)H-Index: 3
Last. Yosuke Demizu (YCU: Yokohama City University)H-Index: 28
view all 5 authors...
Antimicrobial peptides (AMPs) are potential therapeutic agents against bacteria. We recently showed that a rationally designed AMP, termed Stripe, with an amphipathic distribution of native cationic and hydrophobic amino acids on its helical structure exhibited potent antimicrobial activity against Gram-positive and Gram-negative bacteria with negligible hemolytic activity and cytotoxicity. In this study, the structure-activity relationship of Stripe was elucidated by designing a series of antim...
#1Christopher W. Jones (UR: University of Rochester)
#2Crystal G Morales (NAU: Northern Arizona University)
Last. Bradley L. Nilsson (UR: University of Rochester)H-Index: 34
view all 6 authors...
Amphipathic peptides with amino acids arranged in alternating patterns of hydrophobic and hydrophilic residues efficiently self-assemble into β-sheet bilayer nanoribbons. Hydrophobic side chain functionality is effectively buried in the interior of the putative bilayer of these nanoribbons. This study investigates consequences on self-assembly of increasing the surface area of aromatic side chain groups that reside in the hydrophobic core of nanoribbons derived from Ac-(XKXE)2 -NH2 peptides (X =...
#1Francesca Cantini (UniFI: University of Florence)H-Index: 28
#2Paola Giannì (University of Rome Tor Vergata)H-Index: 3
Last. Marco Sette (University of Paris)H-Index: 1
view all 5 authors...
The p28 peptide derived from Pseudomonas aeruginosa azurin shows an anticancer activity after binding to p53 protein and is currently in Phase I of clinical trials. We have studied its structure in water and in a biomimetic media and show that the peptide is unstructured in water but when studied in a biomimetic medium assumes a structure very similar to the one observed in azurin, suggesting a high propensity of this peptide to maintain this secondary structure. Analysis of p28 sequences from d...
#1James SayerH-Index: 3
#2Karin Walldén (Stockholm University)H-Index: 6
Last. Alethea B. TaborH-Index: 24
view all 8 authors...
Helicobacter pylori (H. pylori) infections have been implicated in the development of gastric ulcers and various cancers: however, the success of current therapies is compromised by rising antibiotic resistance. The virulence and pathogenicity of H. pylori is mediated by the type IV secretion system (T4SS), a multiprotein macromolecular nanomachine that transfers toxic bacterial factors and plasmid DNA between bacterial cells, thus contributing to the spread of antibiotic resistance. A key compo...
#1Christos G Papadopoulos (UoI: University of Ioannina)H-Index: 5
#2Evgenia Fotou (UoI: University of Ioannina)
Last. Vassilios Tsikaris (UoI: University of Ioannina)H-Index: 18
view all 9 authors...
The generation of cell-penetrating peptides as cargo-delivery systems has produced an immense number of studies owing to the importance of these systems as tools to deliver molecules into the cells, as well as due to the interest to shed light into a yet unclear mechanism of the entrance of these peptides into the cells. However, many cell-penetrating peptides might present drawbacks due to causing cellular toxicity, or due to being entrapped in endosomes, or as a result of their degradation bef...
#1Wade S. Perkins (Hobart and William Smith Colleges)
#2Ryan T. Davison (Hobart and William Smith Colleges)H-Index: 1
Last. Justin S. Miller (Hobart and William Smith Colleges)H-Index: 2
view all 6 authors...
Hydrophobic latent C-terminal thioesters were converted into thioesters, and were also coupled with cysteine in one-pot reactions, using conditions generally compatible with hydrophobic materials. The reaction conditions (ethanethiol and triethylamine in a mixture of DMF and THF) are compatible with acid-labile protecting groups (Boc/t-Bu) that are standard in Fmoc peptide synthesis.
#1Jing-Yuan Chang (NTU: National Taiwan University)H-Index: 1
#2Nian-Zhi Li (NTU: National Taiwan University)
Last. Orika Kono (NTU: National Taiwan University)
view all 19 authors...
Interactions between charged amino acids significantly influence the structure and function of proteins. The encoded charged amino acids Asp, Glu, Arg, and Lys have different number of hydrophobic methylenes linking the backbone to the charged functionality. It remains to be fully understood how does this difference in the number of methylenes affect protein structure stability. Protein secondary structures are the fundamental three-dimensional building blocks of protein structures. β-Sheet stru...
#1Marco Savioli (University of Rome Tor Vergata)H-Index: 2
#2Lorenzo Antonelli (University of Rome Tor Vergata)
Last. Héctor Santana (Biotec)H-Index: 7
view all 12 authors...
Synthetic therapeutic peptides (STP) are intensively studied as new-generation drugs, characterized by high purity, biocompatibility, selectivity and stereochemical control. However, most of the studies are focussed on the bioactivity of STP without considering how the formulation actually used for therapy administration could alter the physico-chemical properties of the active principle. The aggregation properties of a 20-mer STP (Ac-His-Ala-Arg-Ile-Lys-D-Pro-Thr-Phe-Arg-Arg-D-Leu-Lys-Trp-Lys-T...
#1Sujie Huang (Lanzhou University)H-Index: 2
#2Zhongwen Zhu (Lanzhou University)
Last. Jingjing Song (Lanzhou University)H-Index: 15
view all 5 authors...
Camptothecin (CPT), a DNA-toxin drug, exerts anticancer activity by inhibiting topoisomerase I. Targeted delivery of CPT into the cancer cell nucleus is important for enhancing its therapeutic efficiency. In this study, a new type of acid-activated cell-penetrating peptide (CPP) with nuclear localization capacity was constructed by conjugating six histidine residues and a hydrophobic peptide sequence, PFVYLI, to the nuclear localization sequence (NLS). Our results indicated that HNLS-3 displayed...
Top fields of study
Organic chemistry
Amino acid