Journal of Peptide Science
Papers 2499
1 page of 250 pages (2,499 results)
#1Martin Kloos (GAU: University of Göttingen)
#2Akshita Sharma (GAU: University of Göttingen)H-Index: 1
Last. Ulf Diederichsen (GAU: University of Göttingen)H-Index: 29
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β-Peptides are known to form 14-helices with high conformational rigidity, helical persistence length, and well-defined spacing and orientation regularity of amino acid side chains. Therefore, β-peptides are well suited to serve as backbone structures for molecular rulers. On the one hand, they can be functionalized in a site-specific manner with molecular probes or fluorophores, and on the other hand, the β-peptide helices can be recognized and anchored in a biological environment of interest. ...
#1Rui-fang Li (Henan University of Technology)H-Index: 3
#2Songlin He (Henan University of Technology)
Last. Liang Huang (Henan University of Technology)H-Index: 3
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Infections with multidrug-resistant (MDR) pathogens are increasingly concerning for public health. Synthesized antimicrobial peptide A4 (SAMP-A4), a peptide computationally designed by our research team, is a potential drug candidate. However, the antimicrobial peptide SAMP-A4 is easily degraded in serum. To obtain SAMP-A4 analogues with high biostability, chemical modifications at its N-terminus, including fatty acid conjugation, glycosylation and PEGylation, were carried out. The results showe...
#1Lluís Oliver‐Cervelló (UPC: Polytechnic University of Catalonia)H-Index: 2
#2Helena Martin‐Gómez (UPC: Polytechnic University of Catalonia)H-Index: 2
Last. Carlos Mas-Moruno (UPC: Polytechnic University of Catalonia)H-Index: 24
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Improving cell-material interactions is a major goal in tissue engineering. In this regard, functionalization of biomaterials with cell instructive molecules from the extracellular matrix stands out as a powerful strategy to enhance their bioactivity and achieve optimal tissue integration. However, current functionalization strategies, like the use of native full-length proteins, are associated with drawbacks, thus urging the need of developing new methodologies. In this regard, the use of synth...
#1Kaelyn A Jenny (UVM: University of Vermont)H-Index: 1
#2Erik L. Ruggles (UVM: University of Vermont)H-Index: 11
Last. Robert J. Hondal (UVM: University of Vermont)H-Index: 23
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Ergothioneine (EGT) is the betaine of 2-thiohistidine (2-thioHis) and may be the last undiscovered vitamin. EGT cannot be incorporated into a peptide because the α-nitrogen is trimethylated, although this would be advantageous as an EGT-like moiety in a peptide would impart unique antioxidant and metal chelation properties. The amino acid 2-thioHis is an analogue of EGT and can be incorporated into a peptide, although there is only one reported occurrence of this in the literature. A likely reas...
#1Can Araman (Ladenburg Thalmann)H-Index: 7
#1Can Araman (Ladenburg Thalmann)
#1Dandan Li (Henan University of Technology)
#2Yanhui Yang (Henan University of Technology)
Last. Shuaibo Dong (Henan University of Technology)
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Antimicrobial peptide L163 was computationally designed by our laboratory; L163 is active against multidrug-resistant (MDR) bacteria but is easily degraded in the plasma and by trypsin. Amino acid substitution, cyclization, and amino-terminal (N-terminal) acetylation were performed to obtain L163 analogs with high stability in the plasma and in trypsin solutions. The stability, antimicrobial activity, and biosafety of L163 and its analogs were investigated. Comparison with unmodified L163 indica...
Mastoparan is a small peptide composed of 14 amino acid residues found in wasp venom. It penetrates into cytoplasm through the cell membranes and then binds to a G protein to stimulate the release of histamine. Conformation and its thermal stability of mastoparan from Vespula lewisi (MP) in methanol are investigated by using proton nuclear magnetic resonance (NMR) spectroscopy. On the basis of data on NOESY cross peaks, spin-spin coupling constants between an amide proton (NH) and an α-proton, N...
The goji berry is widely used as tonics; however, the antihuman cervical carcinoma effect and underlying mechanism of goji berry peptide remain to be elucidated. The cyclic peptides are appealing targets in antitumor agent development, and in current study, three novel goji berry cyclic peptides (GCPs) were isolated and amino acid sequence identified. Among them, GCP-1 (Cycle-(Trp-Glu-His-Thr)) inhibited proliferation and induced human cervical cancer (HeLa) cells apoptosis and blocked the HeLa ...
#1Philipp Wolf (Life Sciences Institute)
#2Annette G. Beck-Sickinger (Life Sciences Institute)H-Index: 76
Cardiovascular diseases (CVDs) like hypertension are a major cause for death worldwide. In the cardiovascular tissue, the endothelin system-consisting of the receptor subtypes A (ETA R) and B (ETB R) and the mixed agonist endothelin 1 (ET-1)-is a major key player in the regulation of vascular tone and blood pressure. Tight control of this system is required to maintain homeostasis; otherwise, the endothelin system can cause severe CVDs like pulmonary artery hypertension. The high sequence homolo...
#1Jiaxi Xu (Huada: Beijing University of Chemical Technology)H-Index: 23
#1Jiaxi Xu (Huada: Beijing University of Chemical Technology)H-Index: 19
Sulfonopeptides as the sulfur analogues of natural peptides have been widely used as enzyme inhibitors due to their tetrahedral sulfonamide moiety, which can mimic the transition-state analogues of hydrolysis of the ester and amide bonds. Synthetic methods of sulfonopeptides are reviewed. The synthetic methods of sulfonopeptides include the condensation of N-protected amino acid/peptide acids and 2-aminoalkanesulfonic acids, coupling of N-protected 2-aminoalkanesulfonyl chlorides and amino acid ...
Top fields of study
Organic chemistry
Amino acid