Michelle Vang Mouritzen
Roskilde University
HaCaTCell migrationProinflammatory cytokineChemistryEx vivoSubstance PKeratinocyteCathelicidinHuman umbilical vein endothelial cellStaphylococcus epidermidisNisinCytokineNeurotensinInsulinWound healingScratchKeratinocyte migrationAntimicrobial peptidesMedicinePharmacology
Publications 6
#1Michelle Vang Mouritzen (RU: Roskilde University)H-Index: 4
#2M. Petkovic (UC: University of Coimbra)H-Index: 1
Last. Håvard Jenssen (RU: Roskilde University)H-Index: 38
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Abstract Bovine lactoferricin (LFcinB) has antimicrobial and immunomodulatory properties, however, the effects on diabetic wound healing remain poorly understood. The wound healing potential of LFcinB was investigated using in vitro, ex vivo, and in vivo models. Cell migration and proliferation were tested on keratinocytes and on porcine ears. A type 1 diabetic mouse model was also used to evaluate wound healing kinetics, bacterial diversity patterns and the effect of LFcinB on oxidative stress,...
#1Michelle Vang Mouritzen (RU: Roskilde University)H-Index: 4
#2Athina Andrea (RU: Roskilde University)H-Index: 3
Last. Håvard Jenssen (RU: Roskilde University)H-Index: 38
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: Antimicrobial peptides can have a dual role with both antimicrobial activity against a broad range of bacteria and immunomodulatory effect, making them attractive as therapeutic treatment of difficult wounds. Nisin A is widely known for its antimicrobial activity, and a preliminary study demonstrated that it increased wound closure, but the mechanism behind its effect is unknown. The aim of this study is to elucidate the wound healing potential of Nisin A and the mechanism behind. First, an ep...
7 CitationsSource
#1Michelle Vang Mouritzen (RU: Roskilde University)H-Index: 4
#2Håvard Jenssen (RU: Roskilde University)H-Index: 38
Cell migration is an important process that influences many aspects of health, such as wound healing and cancer, and it is, therefore, crucial for developing methods to study the migration. The scratch assay has long been the most common in vitro method to test compounds with anti- and pro-migration properties because of its low cost and simple procedure. However, an often-reported problem of the assay is the accumulation of cells across the edge of the scratch. Furthermore, to obtain data from ...
9 CitationsSource
#1Paola Saporito (RU: Roskilde University)H-Index: 3
#2Michelle Vang Mouritzen (RU: Roskilde University)H-Index: 4
Last. Håvard Jenssen (RU: Roskilde University)H-Index: 38
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Staphylococcus epidermidis is a common nosocomial pathogen able to form biofilms in indwelling devices, resulting in chronic infections, which are refractory to antibiotics treatment. Staphylococcal biofilms are also associated with the delayed reepithelization and healing of chronic wounds. The human cathelicidin peptide LL-37 has been proven active against S. epidermidis biofilms in vitro and to promote wound healing. As previous studies have demonstrated that fragments of LL-37 could possess ...
15 CitationsSource
#1Michelle Vang Mouritzen (RU: Roskilde University)H-Index: 4
#2Sali Abourayale (RU: Roskilde University)H-Index: 1
Last. Håvard Jenssen (RU: Roskilde University)H-Index: 38
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The work was funded by the Danish Council for Independent Research, Technology and Production, grant 4005‐00029; Strategic Project POCI‐01‐0145‐FEDER‐007440 funded by FEDER through Operational Programme Competitiveness Factors, the European Foundation for the Study of Diabetes (Novartis European Research Programme in Microvascular Complications of Diabetes), and FCT; and Pepper grant P30 AG028718 and NIGMS‐NIH P20GM109096 to EC.
8 CitationsSource