Håvard Jenssen
Roskilde University
Innate immune systemVirologyQuantitative structure–activity relationshipChemistryIn vitroIn vivoVirusLactoferrinPeptidePeptoidHerpes simplex virusLactoferricinMembraneAntimicrobialAntibioticsAntimicrobial peptidesBiochemistryBiologyImmune systemMicrobiology
114Publications
38H-index
5,838Citations
Publications 109
Newest
With a relatively large surface area (2 m2) and 15% of total body mass, the skin forms the largest organ of the human body. The main functions of the skin include regulation of body temperature by insulation or sweating, regulation of the nervous system, regulation of water content, and protection against external injury. To perform these critical functions, the skin encodes genes for transporters responsible for the cellular trafficking of essential nutrients and metabolites to maintain cellula...
Source
#1Michelle Vang Mouritzen (RU: Roskilde University)H-Index: 4
#2M. Petkovic (UC: University of Coimbra)H-Index: 1
Last. Håvard Jenssen (RU: Roskilde University)H-Index: 38
view all 10 authors...
Abstract Bovine lactoferricin (LFcinB) has antimicrobial and immunomodulatory properties, however, the effects on diabetic wound healing remain poorly understood. The wound healing potential of LFcinB was investigated using in vitro, ex vivo, and in vivo models. Cell migration and proliferation were tested on keratinocytes and on porcine ears. A type 1 diabetic mouse model was also used to evaluate wound healing kinetics, bacterial diversity patterns and the effect of LFcinB on oxidative stress,...
Source
#1Biljana Mojsoska (RU: Roskilde University)H-Index: 8
#2Melanie Ghoul (University of Oxford)H-Index: 11
Last. Fatima AlZahraa Alatraktchi (RU: Roskilde University)H-Index: 7
view all 5 authors...
Pseudomonas aeruginosa is an environmental pathogen that can cause severe infections in immunocompromised patients. P. aeruginosa infections are typically treated with multiple antibiotics including tobramycin, ciprofloxacin, and meropenem. However, antibiotics do not always entirely clear the bacteria from the infection site, where they may remain virulent. This is because the effective antibiotic concentration and diffusion in vitro may differ from the in vivo environment in patients. Therefor...
Source
#1Josefine Eilsø Nielsen (University of Oslo)H-Index: 4
#2Victoria Ariel Bjørnestad (University of Oslo)H-Index: 3
Last. Reidar Lund (University of Oslo)H-Index: 26
view all 5 authors...
Abstract Hypothesis: Most textbook models for antimicrobial peptides (AMP) mode of action are focused on structural effects and pore formation in lipid membranes, while these deformations have been shown to require high concentrations of peptide bound to the membrane. Even insertion of low amounts of peptides in the membrane is hypothesized to affect the transmembrane transport of lipids, which may play a key role in the peptide effect on membranes. Experiments: Here we combine state-of-the-art ...
3 CitationsSource
#1Ho Yeon NamH-Index: 4
#2Jieun ChoiH-Index: 3
Last. Jiwon SeoH-Index: 13
view all 15 authors...
The modulation of conformational flexibility in antimicrobial peptides (AMPs) has been investigated as a strategy to improve their efficacy against bacterial pathogens while reducing their toxicity. Here, we synthesized a library of helicity-modulated antimicrobial peptoids by the position-specific incorporation of helix-inducing monomers. The peptoids displayed minimal variations in hydrophobicity, which permitted the specific assessment of the effect of conformational differences on antimicrob...
1 CitationsSource
#1Natalia Molchanova (RU: Roskilde University)
#1Natalia Molchanova (RU: Roskilde University)H-Index: 7
Last. Håvard Jenssen (RU: Roskilde University)H-Index: 38
view all 8 authors...
Antimicrobial peptides have attracted considerable interest as potential new class of antibiotics against multi-drug resistant bacteria. However, their therapeutic potential is limited, in part due to susceptibility towards enzymatic degradation and low bioavailability. Peptoids (oligomers of N-substituted glycines) demonstrate proteolytic stability and better bioavailability than corresponding peptides while in many cases retaining antibacterial activity. In this study, we synthesized a library...
4 CitationsSource
#1Franziska Pietsch (BAM: Bundesanstalt für Materialforschung und -prüfung)H-Index: 2
#2A. J. O'Neill (University of Leeds)H-Index: 1
Last. Frank Schreiber (BAM: Bundesanstalt für Materialforschung und -prüfung)H-Index: 16
view all 8 authors...
Summary Antimicrobial touch surfaces have been introduced in healthcare settings with the aim of supporting existing hygiene procedures, and to help combat the increasing threat of antimicrobial resistance. However, concerns have been raised over the potential selection pressure exerted by such surfaces, which might drive the evolution and spread of antimicrobial resistance. In this review, we highlight studies that indicate risks associated with resistance on antimicrobial surfaces by different...
7 CitationsSource
#1Foteini TsakouH-Index: 1
Last. Biljana MojsoskaH-Index: 8
view all 4 authors...
For many years, we have tried to use antibiotics to eliminate the persistence of pathogenic bacteria. However, these infectious agents can recover from antibiotic challenges through various mechanisms, including drug resistance and antibiotic tolerance, and continue to pose a global threat to human health. To design more efficient treatments against bacterial infections, detailed knowledge about the bacterial response to the commonly used antibiotics is required. Proteomics is a well-suited and ...
1 CitationsSource
#1Ines Greco (UCPH: University of Copenhagen)H-Index: 9
#2Natalia Molchanova (RU: Roskilde University)H-Index: 7
Last. Johan Svenson (Cawthron Institute)H-Index: 1
view all 9 authors...
The use of non-standard toxicity models is a hurdle in the early development of antimicrobial peptides towards clinical applications. Herein we report an extensive in vitro and in vivo toxicity study of a library of 24 peptide-based antimicrobials with narrow spectrum activity towards veterinary pathogens. The haemolytic activity of the compounds was evaluated against four different species and the relative sensitivity against the compounds was highest for canine erythrocytes, intermediate for r...
8 CitationsSource
#1B. David Persson (Umeå University)H-Index: 9
#2Annasara Lenman (Umeå University)H-Index: 5
Last. Niklas Arnberg (Umeå University)H-Index: 27
view all 8 authors...
Virus entry into host cells is a complex process that is largely regulated by the access to specific cellular receptors. Human adenoviruses (HAdVs) and many other viruses use cell adhesion molecules such as the Coxsackievirus and adenovirus receptor (CAR) for attachment to and entry into target cells. These molecules are rarely expressed on the apical side of polarized epithelial cells, which raise the question how adenovirus - and other viruses that engage cell adhesion molecules - enter polari...
7 CitationsSource