Original paper

Backbone-free duplex-stacked monomer nucleic acids exhibiting Watson–Crick selectivity

Abstract
We demonstrate that nucleic acid (NA) mononucleotide triphosphates (dNTPs and rNTPs), at sufficiently high concentration and low temperature in aqueous solution, can exhibit a phase transition in which chromonic columnar liquid crystal ordering spontaneously appears. Remarkably, this polymer-free state exhibits, in a self-assembly of NA monomers, the key structural elements of biological nucleic acids, including: long-ranged duplex stacking of...
Paper Details
Title
Backbone-free duplex-stacked monomer nucleic acids exhibiting Watson–Crick selectivity
Published Date
Jul 2, 2018
Volume
115
Issue
33
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