Oxidative Stress in Preeclampsia and Placental Diseases.

Published on May 17, 2018in International Journal of Molecular Sciences4.556
· DOI :10.3390/IJMS19051496
Rajaa Aouache1
Estimated H-index: 1
(French Institute of Health and Medical Research),
Louise Biquard2
Estimated H-index: 2
+ 1 AuthorsFrancisco Miralles16
Estimated H-index: 16
Preeclampsia is a persistent hypertensive gestational disease characterized by high blood pressure and proteinuria, which presents from the second trimester of pregnancy. At the cellular level, preeclampsia has largely been associated with the release of free radicals by the placenta. Placenta-borne oxidative and nitrosative stresses are even sometimes considered as the major molecular determinants of the maternal disease. In this review, we present the recent literature evaluating free radical production in both normal and pathological placentas (including preeclampsia and other major pregnancy diseases), in humans and animal models. We then assess the putative effects of these free radicals on the placenta and maternal endothelium. This analysis was conducted with regard to recent papers and possible therapeutic avenues.
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