Antibody

Monoclonal antibody

Monoclonal

Immunology

Medicine

Nature Reviews Nephrology

Monoclonal immunoglobulin deposition produces complex diseases with heterogeneous phenotypes, making it difficult to identify the underlying mechanisms of immunoglobulin aggregation and deposition. In this Review, the authors discuss animal models of various human immunoglobulin deposition diseases, and each model's drawbacks and contributions to our understanding of these diseases. The renal deposition of monoclonal immunoglobulins can cause severe renal complications in patients with B cell and plasma cell lymphoproliferative disorders. The overproduction of a structurally unique immunoglobulin can contribute to the abnormal propensity of monoclonal immunoglobulins to aggregate and deposit in specific organs. A wide range of renal diseases can occur in multiple myeloma or monoclonal gammopathy of renal significance, including tubular and glomerular disorders with organized or unorganized immunoglobulin deposits. The development of reliable experimental models is challenging owing to the inherent variability...

Animal models of monoclonal immunoglobulin-related renal diseases