Silver-pig skin nanocomposites and mesenchymal stem cells: suitable antibiofilm cellular dressings for wound healing.

Published on Jan 10, 2018in Journal of Nanobiotechnology6.518
· DOI :10.1186/S12951-017-0331-0
Mario Alberto Pérez-Díaz5
Estimated H-index: 5
(IPN: Instituto Politécnico Nacional),
Mario Alberto Pérez-Díaz2
Estimated H-index: 2
(IPN: Instituto Politécnico Nacional)
+ 12 AuthorsRoberto Sánchez-Sánchez8
Estimated H-index: 8
Sources
Abstract
Background Treatment of severe or chronic skin wounds is an important challenge facing medicine and a significant health care burden. Proper wound healing is often affected by bacterial infection; where biofilm formation is one of the main risks and particularly problematic because it confers protection to microorganisms against antibiotics. One avenue to prevent bacterial colonization of wounds is the use of silver nanoparticles (AgNPs); which have proved to be effective against non-multidrug-resistant and multidrug-resistant bacteria. In addition, the use of mesenchymal stem cells (MSC) is an excellent option to improve wound healing due to their capability for differentiation and release of relevant growth factors. Finally, radiosterilized pig skin (RPS) is a biomatrix successfully used as wound dressing to avoid massive water loss, which represents an excellent carrier to deliver MSC into wound beds. Together, AgNPs, RPS and MSC represent a potential dressing to control massive water loss, prevent bacterial infection and enhance skin regeneration; three essential processes for appropriate wound healing with minimum scaring.
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