Journal of Nanobiotechnology
Papers 1,358
1 page of 136 pages (1,358 results)
#1Jiao Guo (CAMS&PUMC: Chinese Academy of Medical Sciences & Peking Union Medical College)
#2Haiyu Yang (CAMS&PUMC: Chinese Academy of Medical Sciences & Peking Union Medical College)
Last. Xiaodong Zhang (TJU: Tianjin University)H-Index: 37
view all 10 authors...
BACKGROUND As we know, radiotherapy plays an irreplaceable role in the clinical management on solid tumors. However, due to the non-specific killing effects of ionizing radiation, normal tissues damages would be almost simultaneous inevitably. Therefore, ideal radioprotective agents with high efficiency and low toxicity are always desirable. In this work, atomically precise Ag14 clusterzymes were developed, and their applications in radioprotection were studied in vitro and in vivo for the first...
#1Xiaojing Xu (Soochow University)H-Index: 5
#2Minfeng Gan (Soochow University)H-Index: 11
Last. Lixiang Zhao (Soochow University)H-Index: 10
view all 11 authors...
ABSTARCT BACKGROUND: Cytosine-phosphate-guanine (CpG) dinucleotides has been used as adjuvants for cancer immunotherapy. However, unmodified CpG are not very efficient in clinical trials. Glucose, ligand of C-type lectin receptors (CLRs), can promote DC maturation and antigen presentation, which is the first step of induction of adaptive immune responses. Therefore, conjugation of type B CpG DNA to glucose-containing glycopolymers may enhance the therapeutic effects against tumor by CpG-based va...
#1Zaigang Zhou (WMC: Wenzhou Medical University)H-Index: 4
#2Ning Jiang (KMUST: Kunming University of Science and Technology)
Last. Jianliang Shen (CAS: Chinese Academy of Sciences)H-Index: 29
view all 8 authors...
BACKGROUND Mild-temperature photothermal therapy (mild-PTT) has emerged as a highly promising antitumor strategy by triggering immunogenic cell death (ICD) to elicit both innate and adaptive immune responses for tumor control. However, mild-PTT still leads to the risk of tumor recurrence or metastasis because it could hardly completely eradicate tumors due to its impaired immunological efficacy owing to the enhanced PD-L1 expression in tumor cells after treatment. RESULTS In this study, we descr...
#1Zhuxin Wei (Soochow University)
#2Guangxin Duan (Soochow University)H-Index: 1
Last. Ling Wen (Soochow University)H-Index: 8
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BACKGROUND Fluorescence imaging as the beacon for optical navigation has wildly developed in preclinical studies due to its prominent advantages, including noninvasiveness and superior temporal resolution. However, the traditional optical methods based on ultraviolet (UV, 200-400 nm) and visible light (Vis, 400-650 nm) limited by their low penetration, signal-to-noise ratio, and high background auto-fluorescence interference. Therefore, the development of near-infrared-II (NIR-II 1000-1700 nm) n...
#1Jimin KimH-Index: 3
#2Seul LeeH-Index: 1
Last. Soo Hyun KimH-Index: 7
view all 7 authors...
BACKGROUND Extracellular vesicles (EVs) are recognized as novel cell-free therapeutics. Non-alcoholic steatohepatitis (NASH) remains a critical health problem. Herein, we show that EVs from pan peroxisome proliferator-activated receptor agonist-primed induced mesenchymal stem cell (pan PPAR-iMSC-EVs) has unique cargo protein signatures, and demonstrate its therapeutic function in NASH. RESULTS A unique protein signatures were identified in pan PPAR-iMSC-EVs against those from non-stimulated iMSC...
#1Boyan Liu (CQU: Chongqing University)H-Index: 2
#2Wenhua Yan (CQMU: Chongqing Medical University)H-Index: 3
Last. Kun Zhang (CQU: Chongqing University)H-Index: 12
view all 14 authors...
BACKGROUND Intimal hyperplasia caused by vascular injury is an important pathological process of many vascular diseases, especially occlusive vascular disease. In recent years, Nano-drug delivery system has attracted a wide attention as a novel treatment strategy, but there are still some challenges such as high clearance rate and insufficient targeting. RESULTS In this study, we report a biomimetic ROS-responsive MM@PCM/RAP nanoparticle coated with macrophage membrane. The macrophage membrane w...
#1Yiqun Mo (UCINF: University Ucinf)H-Index: 20
#2Yue Zhang (UCINF: University Ucinf)H-Index: 4
Last. Qunwei Zhang (UCINF: University Ucinf)H-Index: 27
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BACKGROUND Nickel nanoparticles (Nano-Ni) are increasingly used in industry and biomedicine with the development of nanotechnology. However, the genotoxic and carcinogenic effects of Nano-Ni and the underlying mechanisms are still unclear. METHODS At first, dose-response (0, 10, 20, and 30 μg/mL) and time-response (0, 3, 6, 12, and 24 h) studies were performed in immortalized normal human bronchial epithelial cells BEAS-2B to observe the effects of Nano-Ni on DNA damage response (DDR)-associated...
#1Shao-bo Bai (FMMU: Air Force Medical University)H-Index: 2
#2Yang Sun (FMMU: Air Force Medical University)H-Index: 55
Last. Dao-zhou Liu (FMMU: Air Force Medical University)H-Index: 12
view all 11 authors...
BACKGROUND Colon cancer is a most common malignant cancer in digestive system, and it is prone to develop resistance to the commonly used chemotherapy drugs, leading to local recurrence and metastasis. Paris saponin VII (PSVII) could not only inhibit the proliferation of colon cancer cells but also effectively induce apoptosis of drug-resistant colon cancer cells and reduce the metastasis of drug-resistant colon cancer cells as well. However, PSVII was insoluble in water and fat. It displayed no...
#1Chuanjie ZhangH-Index: 2
#2Daoyong LiH-Index: 4
Last. He TianH-Index: 3
view all 10 authors...
Background null Uncontrollable inflammation and nerve cell apoptosis are the most destructive pathological response after spinal cord injury (SCI). So, inflammation suppression combined with neuroprotection is one of the most promising strategies to treat SCI. Engineered extracellular vesicles with anti-inflammatory and neuroprotective properties are promising candidates for implementing these strategies for the treatment of SCI. null Results null By combining nerve growth factor (NGF) and curcu...
#1Yuan DingH-Index: 4
#2Yanjie LiH-Index: 3
view all 8 authors...
Humans have a limited postinjury regenerative ability. Therefore, cell-derived biomaterials have long been utilized for tissue repair. Cells with multipotent differentiation potential, such as stem cells, have been administered to patients for the treatment of various diseases. Researchers expected that these cells would mediate tissue repair and regeneration through their multipotency. However, increasing evidence has suggested that in most stem cell therapies, the paracrine effect but not cell...
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