Journal of Nanobiotechnology
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#1Antul Kumar (PAU: Punjab Agricultural University)H-Index: 4
#2Anuj Choudhary (PAU: Punjab Agricultural University)H-Index: 4
Last. Azamal HusenH-Index: 25
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Due to the global rise of the human population, one of the top-most challenges for poor and developing nations is to use the food produces safely and sustainably. In this regard, the storage of surplus food (and derived products) without loss of freshness, nutrient stability, shelf life, and their parallel efficient utilization will surely boost the food production sector. One of the best technologies that have emerged within the last twenty years with applications in the packaging of food and i...
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#1Rui BaiH-Index: 1
#2Jianfeng Liu (Chinese PLA General Hospital)H-Index: 1
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BACKGROUND The niche of tissue development in vivo involves the growth matrix, biophysical cues and cell-cell interactions. Although natural extracellular matrixes may provide good supporting for seeding cells in vitro, it is evitable to destroy biophysical cues during decellularization. Reconstructing the bioactivities of extracellular matrix-based scaffolds is essential for their usage in tissue repair. RESULTS In the study, a hybrid hydrogel was developed by incorporating single-wall carbon n...
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#1Ying Zhang (Tianjin University of Traditional Chinese Medicine)H-Index: 2
#2Pan Guo (Tianjin University of Traditional Chinese Medicine)H-Index: 4
Last. Zhidong Liu (Tianjin University of Traditional Chinese Medicine)H-Index: 14
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Although nanomedicine have greatly developed and human life span has been extended, we have witnessed the soared incidence of central nervous system (CNS) diseases including neurodegenerative diseases (Alzheimer’s disease, Parkinson’s disease), ischemic stroke, and brain tumors, which have severely damaged the quality of life and greatly increased the economic and social burdens. Moreover, partial small molecule drugs and almost all large molecule drugs (such as recombinant protein, therapeutic ...
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#1Yan Wang (Qingdao University)H-Index: 5
#2Xiaoyuan Zhang (Huada: Beijing University of Chemical Technology)H-Index: 11
Last. Zhiqiang Su (Huada: Beijing University of Chemical Technology)H-Index: 46
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Peptide molecule has high bioactivity, good biocompatibility, and excellent biodegradability. In addition, it has adjustable amino acid structure and sequence, which can be flexible designed and tailored to form supramolecular nano-assemblies with specific biomimicking, recognition, and targeting properties via molecular self-assembly. These unique properties of peptide nano-assemblies made it possible for utilizing them for biomedical and tissue engineering applications. In this review, we summ...
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#1Jiangkang Xu (SDU: Shandong University)H-Index: 5
#2Xiaoye Yang (SDU: Shandong University)H-Index: 17
Last. Guangxi Zhai (SDU: Shandong University)H-Index: 45
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Background null Glioblastoma is a lethal neoplasm with few effective therapy options. As a mainstay in the current treatment of glioma at present, chemotherapeutic agents usually show inadequate therapeutic efficiency due to their low blood brain barrier traversal and brain targeting, together with tumor multidrug resistance. Novel treatment strategies are thus urgently needed to improve chemotherapy outcomes. null Results null Here, we report that nanomedicines developed by functionalizing the ...
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#1Rachel R. Mizenko (UC Davis: University of California, Davis)H-Index: 1
#2Terza Brostoff (UCSD: University of California, San Diego)
Last. Randy P. Carney (UC Davis: University of California, Davis)H-Index: 21
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Background null Tetraspanin expression of extracellular vesicles (EVs) is often used as a surrogate for their detection and classification, a practice that typically assumes their consistent expression across EV sources. null Results null Here we demonstrate that there are distinct patterns in colocalization of tetraspanin expression of EVs enriched from a variety of in vitro and in vivo sources. We report an optimized method for the use of single particle antibody-capture and fluorescence detec...
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#1Shan‐Shan Wang (SJTU: Shanghai Jiao Tong University)H-Index: 1
#2Zi-Kai Liu (SJTU: Shanghai Jiao Tong University)
Last. Mingke Song (SJTU: Shanghai Jiao Tong University)H-Index: 22
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Discovery of early-stage biomarkers is a long-sought goal of Alzheimer’s disease (AD) diagnosis. Age is the greatest risk factor for most AD and accumulating evidence suggests that age-dependent elevation of asparaginyl endopeptidase (AEP) in the brain may represent a new biological marker for predicting AD. However, this speculation remains to be explored with an appropriate assay method because mammalian AEP exists in many organs and the level of AEP in body fluid isn’t proportional to its con...
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#1Tian Ding (SDU: Shandong University)H-Index: 1
#2Wenyan Kang (SDU: Shandong University)
Last. Shaohua Ge (SDU: Shandong University)H-Index: 21
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Background The regeneration of periodontal bone defect remains a vital clinical challenge. To date, numerous biomaterials have been applied in this field. However, the immune response and vascularity in defect areas may be key factors that are overlooked when assessing the bone regeneration outcomes of biomaterials. Among various regenerative therapies, the up-to-date strategy of in situ tissue engineering stands out, which combined scaffold with specific growth factors that could mimic endogeno...
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#1Yan Chen (HUST: Huazhong University of Science and Technology)H-Index: 9
#2Lei Fang (HUST: Huazhong University of Science and Technology)
Last. Yao Lu (HUST: Huazhong University of Science and Technology)H-Index: 9
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BACKGROUND Hypoxic tumor microenvironment (TME) promotes tumor metastasis and drug resistance, leading to low efficiency of cancer chemotherapy. The development of targeted agents or multi-target therapies regulating hypoxic microenvironment is an important approach to overcome drug resistance and metastasis. METHODS In this study, chitosan oligosaccharide (COS)-coated and sialic acid (SA) receptor-targeted nano-micelles were prepared using film dispersion method to co-deliver cisplatin (CDDP) a...
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#1Yongtai Zhang (SHU: Shanghai University)H-Index: 19
#2Qing Xia (SHU: Shanghai University)H-Index: 3
Last. Zhi Wang (SHU: Shanghai University)H-Index: 9
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Background null A red blood cell membrane (RBCm)-derived drug delivery system allows prolonged circulation of an antitumor treatment and overcomes the issue of accelerated blood clearance induced by PEGylation. However, RBCm-derived drug delivery systems are limited by low drug-loading capacities and the lack of tumor-targeting ability. Thus, new designs of RBCm-based delivery systems are needed. null Results null Herein, we designed hyaluronic acid (HA)-hybridized RBCm (HA&RBCm)-coated lipid mu...
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