Integrated Molecular Characterization of the Lethal Pediatric Cancer Pancreatoblastoma
Abstract
Pancreatoblastoma is a rare pediatric pancreatic malignancy for which the molecular pathogenesis is not understood. In this study, we report the findings of an integrated multiomics study of whole-exome and RNA sequencing as well as genome-wide copy number and methylation analyses of ten pancreatoblastoma cases. The pancreatoblastoma genome was characterized by a high frequency of aberrant activation of the Wnt signaling pathway, either via...
Paper Details
Title
Integrated Molecular Characterization of the Lethal Pediatric Cancer Pancreatoblastoma
Published Date
Feb 14, 2018
Journal
Volume
78
Issue
4
Pages
865 - 876
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