Two new cytotoxic stilbenoid dimers isolated from Cajanus cajan

Published on Jan 1, 2018in Journal of Natural Medicines2.055
· DOI :10.1007/S11418-017-1138-X
Nenling Zhang5
Estimated H-index: 5
(CAS: Chinese Academy of Sciences),
Xiangchun Shen2
Estimated H-index: 2
+ 4 AuthorsSamuel X. Qiu4
Estimated H-index: 4
(CAS: Chinese Academy of Sciences)
Two new stilbenoid dimers, cajanstilbenoids A (1) and B (2), were isolated from the leaves of Cajanus cajan. Planar structures of these compounds were verified by NMR (1D and 2D) and high-resolution electrospray ionization mass spectroscopy (HR-ESI–MS). Absolute configurations were assigned by comparing experimental and calculated electronic CD values. The cytotoxicity of 1 and 2 against human hepatoma (HepG2), human breast adenocarcinoma (MCF-7), and human lung cancer (A549) cells were evaluated in vitro. Compound 1 showed strong cytotoxicity against all the tested cell lines (IC50 values: 2.14–2.56 µM), whereas compound 2 showed strong toxicity only against HepG2 (IC50 value: 5.99 µM) and A549 cells (IC50 value: 6.18 µM).
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