Nenling Zhang
Chinese Academy of Sciences
CytotoxicityChemistryTwo-dimensional nuclear magnetic resonance spectroscopyMesenchymal stem cellIn vitroFlavonesBrucea javanicaFlavanoneCajanusSimaroubaceaeKaempferolIsoflavonoidStilbenoidQuassinoidBiochemistryTraditional medicineStereochemistryCell cultureBiologyColorimetry (chemical method)
9Publications
5H-index
43Citations
Publications 8
Newest
#1Nenling Zhang (CAS: Chinese Academy of Sciences)H-Index: 5
#2Xiangchun ShenH-Index: 2
Last. Samuel X. Qiu (CAS: Chinese Academy of Sciences)H-Index: 4
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Two new stilbenoid dimers, cajanstilbenoids A (1) and B (2), were isolated from the leaves of Cajanus cajan. Planar structures of these compounds were verified by NMR (1D and 2D) and high-resolution electrospray ionization mass spectroscopy (HR-ESI–MS). Absolute configurations were assigned by comparing experimental and calculated electronic CD values. The cytotoxicity of 1 and 2 against human hepatoma (HepG2), human breast adenocarcinoma (MCF-7), and human lung cancer (A549) cells were evaluate...
3 CitationsSource
#1Jia-Zhong CaiH-Index: 4
#2Rong TangH-Index: 3
Last. Xiao-Ling ShenH-Index: 7
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A new natural halogen-containing stilbene derivative was isolated from the leaves of Cajanus cajan (L.) Millsp. and identified as 3-O-(3-chloro-2-hydroxyl-propanyl)-longistylin A by comprehensive spectroscopic and chemical analysis, and named cajanstilbene H (1). It is the first halogen-containing stilbene derivative found from plants. In human mesenchymal stem cells (hMSC) from bone marrow, 1 did not promote cell proliferation, but distinctly enhanced osteogenic differentiation of hMSC in time-...
6 CitationsSource
#1Nenling Zhang (CAS: Chinese Academy of Sciences)H-Index: 5
#2Riming Huang (CAS: Chinese Academy of Sciences)H-Index: 10
Last. Samuel X. Qiu (CAS: Chinese Academy of Sciences)H-Index: 4
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A new isoprenylated flavanone, naringenin-3′-isoprenyl-7-methyl ether, was isolated from the chloroform extract of the leaves of Cajanus cajan. Its structure was eluciated by spectral analysis, mainly 1D and 2D NMR.
Source
#1Zhiwei Su (CAS: Chinese Academy of Sciences)H-Index: 4
#2Jing Hao (CAS: Chinese Academy of Sciences)H-Index: 9
Last. Sheng-Xiang Qiu (CAS: Chinese Academy of Sciences)H-Index: 16
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A new minor quassinoid named bruceine M (1), together with 12 known quassinoids (2–13), was isolated from the fruits of Brucea javanica (Simaroubaceae). Their structures were determined by interpretation of NMR and HR-ESI-MS data. The structures of the known compounds were confirmed by comparison of their spectral data with those reported in the literatures. In vitro cytotoxicity of the isolated compounds against cancer cell lines Bel-7404, MCF-7 and A549 was evaluated. Compounds 4, 6 and 9 exhi...
9 CitationsSource
#1Manqin Fu (CAS: Chinese Academy of Sciences)H-Index: 3
#2Dun DengH-Index: 1
Last. Samuel X. Qiu (CAS: Chinese Academy of Sciences)H-Index: 4
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One new flavanocoumarin, flemicoumarin A (1) was isolated from the EtOAc-soluble partition of the root of Flemingia philippinensis, along with three known compounds, namely 4,2′-epoxy-4′,5-dihydroxy-7,5′-dimethoxy-3-phenylcoumarin (2), kaempferol 6-C-glucoside (3) and dracocephaloside (4). The structure of compound 1 was elucidated on the basis of its 1D, 2D NMR, CD and MS data. The structures of the known compounds were identified by comparison of their spectroscopic data with those reported in...
5 CitationsSource
#1Ri-Ming Huang (CAS: Chinese Academy of Sciences)H-Index: 2
#2Huijuan Huang (SCNU: South China Normal University)H-Index: 3
Last. Samuel X. Qiu (CAS: Chinese Academy of Sciences)H-Index: 4
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Two new lignans, named zuihonins E (1) and F (2), were isolated from the stems of Schisandra bicolor Cheng var. tuberculata Law. The structures of the new lignans were elucidated on the basis of extensive spectroscopic analysis, including 1D, 2D NMR, and MS experiments, and their absolute stereochemistry was determined by circular dichroism spectrum. Compounds 1 and 2 did not inhibit the growth of hepatoma carcinoma cell (HepG2), lung carcinoma cell (A549), and human breast carcinoma (MCF-7) cel...
4 CitationsSource
#1Manqin Fu (CAS: Chinese Academy of Sciences)H-Index: 2
#2Shixiu Feng (CAS: Chinese Academy of Sciences)H-Index: 3
Last. Samuel X. Qiu (CAS: Chinese Academy of Sciences)H-Index: 4
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A new prenylated isoflavonoid, flemiphilippinin G (1), and a new flavonol glycoside, flemiphilippininside (2), along with eleven known isoflavonoids were obtained from the roots of Flemingia philippinensis (Merr. et Rolfe) Li. Their structures were elucidated on the basis of spectroscopic data. The in vitro cytotoxicities of compounds 1–13 against MCF-7, A549, and Hep-G2 cell lines were determined by using the MTT (=3-(4,5-dimethylthazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide) colorimetric as...
9 CitationsSource
#1Nenling ZhangH-Index: 5
#2Yue-Hui ZhuH-Index: 8
Last. Sheng-Xiang QiuH-Index: 16
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Two new stilbenoids cajanotone and cajanamide A (1-2), together with another six known ones (3- 8) and four known dihydroflavones (9-12), have been isolated from the leaves of Cajanus cajan. Their structures were elucidated based on spectroscopic studies. A possible pathway to the new compounds 1 and 2 has been proposed. In vitro cytotoxicities of selected compounds against cancer cell lines HepG2, MCF-7 and A549 have been evaluated. Compounds 7 and 8 show strong cytotoxity against all the teste...
9 CitationsSource
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