Journal of Natural Medicines
Papers 1508
1 page of 151 pages (1,508 results)
#1Xianbang Hou (Nanjing University of Chinese Medicine)
#2Xueyuan Zhang (Nanjing University of Chinese Medicine)
Last. Liwei He (Nanjing University of Chinese Medicine)
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Human respiratory syncytial virus (RSV) is highly contagious and the leading cause of severe respiratory tract illness in infants, elderly, and immunocompromised individuals. Toll-like receptor 7 (TLR7), a pattern recognition receptor recognising the ssRNA of RSV, activates proinflammatory pathways and triggers secretion of interferons (IFNs). On the one hand, the inflammatory responses help clear out virus. On the other hand, they lead to severe lung damage. Banlangen is a traditional Chinese h...
Colorectal cancer stem cells (CSCs) have the potential for self-renewal, proliferation, and differentiation. And LGR5 is a stem cell marker gene of colorectal cancer. Curcumin can suppress oncogenicity of many cancer cells, yet the effect and mechanism of curcumin in LGR5(+) colorectal cancer stem cells (CSCs) have not been studied. In this study, we studied the effect of curcumin on LGR5(+) colorectal CSCs using the experiments of tumorsphere formation, cell viability and cell apoptosis. Then a...
#1Kayoko Shimada-Takaura (Osaka University)H-Index: 2
#2Kazuhiko Ninomiya (Osaka University)H-Index: 11
Last. Kyoko Takahashi (Osaka University)H-Index: 24
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OGATA Koan (1810-63) was a physician and the director of Tekijuku, and he contributed to Western medicine in the late Edo period. Osaka University preserves two of his medicine chests. One of the chests, which was used in his last years (the second chest) contained 22 glass bottles and 6 wooden cylinders. These bottles and cylinders contained formulated medicines; however, about half cannot be opened because of the long-term storage. It is necessary to comprehend the physical property of both th...
#1Prema (University of Toyama)H-Index: 4
#2Takeshi Kodama (University of Toyama)H-Index: 9
Last. Hiroyuki Morita (University of Toyama)H-Index: 23
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New copaene-type and nerolidol-type sesquiterpenoids, 7-hydroxymustakone (1) and 15-hydroxynerolidol (2), and a 15-norlabdane diterpenoid, kaempcandiol (3), together with four known compounds (4-7) were isolated from the chloroform extract of Kaempferia candida roots and rhizomes. The structures of the new compounds 1-3 were elucidated based on 1D and 2D NMR and HRESIMS spectroscopic analyses. The extract of the K. candida roots and rhizomes and all isolated compounds 1-7 possessed HIV-1 viral p...
#1Syahadatain Nor Haerani (Chula: Chulalongkorn University)
#2Achara Raksat (Chula: Chulalongkorn University)
Last. Khanitha Pudhom (Chula: Chulalongkorn University)H-Index: 17
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Two new xanthones, 1,3,6,7-tetrahydroxy-5-methoxy-4-(1',1'-dimethyl-2'-propenyl)-8-(3″,3″-dimethyl-2″-propenyl)-xanthone (1) and (2'S)-7-hydroxy caloxanthone B (2), were isolated from the root of Thai Calophyllum inophyllum Linn., together with twelve known xanthones (3-14). The structures of new compounds were elucidated based on spectroscopic data. In addition, compounds 4, 6 and 8 were isolated from the genus Calophyllum for the first time. The isolated compounds were evaluated for their cyto...
It has been proposed that biosyntheses of many natural products involve pericyclic reactions, including Diels-Alder (DA) reaction. However, only a small set of enzymes have been proposed to catalyze pericyclic reactions. Most surprisingly, there has been no formal identification of natural enzymes that can be defined to catalyze DA reactions (DAases), despite the wide application of the reaction in chemical syntheses of complex organic compounds. However, recent studies began to accumulate a gro...
#1Yoshitomi Kudo (Kanazawa University)H-Index: 1
#2Hirokazu Ando (Kanazawa University)H-Index: 3
Last. Yohei Sasaki (Kanazawa University)H-Index: 5
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By using Angelica acutiloba seedlings produced by short-period raising in paper pot (PP), we investigated the effect of taproot base diameter on the growth after planting and evaluated the quality of toki (, Angelicae Acutilobae Radix) produced from PP-grown seedlings (PT). In this study, PP-grown seedlings of seven classes which are sorted difference taproot base diameter (P1-P7) were transplanted. As a result, the survival rates were not less than 90% for P6 (taproot base diameter: 10.0-12.7 c...
#1Jianbo Wu (Kyoto Pharmaceutical University)H-Index: 2
#2Souichi Nakashima (Kyoto Pharmaceutical University)H-Index: 15
Last. Hisashi Matsuda (Kyoto Pharmaceutical University)H-Index: 66
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The article Antihypertensive constituents in Sanoshashinto, written by Jianbo Wu, Souichi Nakashima, Marina Shigyo, Mutsumi Yamasaki, Sumire Ikuno, Aoi Morikawa, Shigehiko Takegami, Seikou Nakamura, Atsuko Konishi, Tatsuya Kitade and Hisashi Matsuda, was originally published Online First without Open Access.
#1Takayoshi Awakawa (UTokyo: University of Tokyo)H-Index: 23
The teleocidin B family members are terpene indole compounds isolated from Streptomyces bacteria, and they strongly activate protein kinase C (PKC). Their unique structures have attracted many researchers in the natural product chemistry and pharmacology fields, and numerous isolation and bioactivity studies have been conducted. The accumulated information has facilitated the identification of the enzymatic reactions in teleocidin biosynthesis, and new developments in structural biology have str...
#1Keping Wang (Nanjing Medical University)
#2Bin Wang (Nanjing Medical University)
Last. Rusong Yang (Nanjing Medical University)
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Angiogenesis is a key event in non-small cell lung cancer progression. Alginic acid (AA), a kind of naturally occurring polyuronic acid, is generally enriched in edible brown algae. Recent studies have uncovered its anti-anaphylactic and anti-inflammatory properties. However, the effects of AA on human malignancies remain unknown. Herein, efficient inhibition of AA on NSCLC-induced angiogenesis was observed with tube formation and xenograft models. Subsequent results indicated that AA downregula...
Top fields of study
Traditional medicine