Successful treatment of a hepatic-hemangioendothelioma infant presenting with hypothyroidism and tetralogy of Fallot

Published on Aug 12, 2017in Pediatrics and Neonatology2.083
· DOI :10.1016/J.PEDNEO.2017.08.002
Akari Takai2
Estimated H-index: 2
(Kyoto Prefectural University of Medicine),
Tomoko Iehara22
Estimated H-index: 22
(Kyoto Prefectural University of Medicine)
+ 7 AuthorsHajime Hosoi31
Estimated H-index: 31
(Kyoto Prefectural University of Medicine)
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Abstract
References6
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#1Denise M. Adams (Cincinnati Children's Hospital Medical Center)H-Index: 29
#2Cameron C. Trenor (UC: University of Cincinnati)H-Index: 24
Last. Richard G Azizkhan (Boston Children's Hospital)H-Index: 5
view all 24 authors...
BACKGROUND AND OBJECTIVES: Complicated vascular anomalies have limited therapeutic options and cause significant morbidity and mortality. This Phase II trial enrolled patients with complicated vascular anomalies to determine the efficacy and safety of treatment with sirolimus for 12 courses; each course was defined as 28 days. METHODS: Treatment consisted of a continuous dosing schedule of oral sirolimus starting at 0.8 mg/m 2 per dose twice daily, with pharmacokinetic-guided target serum trough...
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#1Mohamed M. D. Aly (Ain Shams University)H-Index: 2
#2Alaa F. Hamza (Ain Shams University)H-Index: 13
Last. Iman A. Ragab (Ain Shams University)H-Index: 8
view all 6 authors...
Infantile hemangiomas are the most common benign childhood tumor that may have functional and/or cosmetic complications. We aimed to compare the clinical efficacy of propranolol alone and propranolol primed with systemic corticosteroids on the outcome of infantile hemangioma. A prospective randomized study included 40 infants aged less than 9 months with cutaneous hemangiomas. Patients were randomly assigned into two groups: group A were given oral prednisolone for the initial 2 weeks combined w...
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#1Nilika Wijeratne (Monash University, Clayton campus)H-Index: 4
#3Peter J Simm (Royal Children's Hospital)H-Index: 16
Last. James C.G. Doery (Monash University, Clayton campus)H-Index: 21
view all 4 authors...
A full-term baby boy underwent an ultrasound scan of the abdomen at 6 weeks of age for the follow-up of an antenatal diagnosis of left-sided hydronephrosis. Although there was no hydronephrosis, the abdominal ultrasound revealed an enlarged liver with multiple hypoechoic lesions measuring up to 25 mm in diameter. He was admitted to the hospital for further evaluation of the hepatic lesions. Examination revealed multiple small external hemangiomas on the scalp and both wrists and axilla. The infa...
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#1Eun Hee Kim (UOU: University of Ulsan)H-Index: 19
#2Kyung Nam Koh (UOU: University of Ulsan)H-Index: 14
Last. Jong Jin Seo (UOU: University of Ulsan)H-Index: 23
view all 6 authors...
Purpose: Infantile hepatic hemangioendothelioma (IHHE) is the most common type of hepatic vascular tumor in infancy. We conducted this study to review our clinical experience of patients with IHHE and to suggest management strategies. Methods: We retrospectively analyzed the medical records of 23 IHHE patients (10 males, 13 females) treated at the Asan Medical Center between 1996 and 2009. Results: Median age at diagnosis was 38 days (range, 1 to 381 days). Seven patients (30%) were diagnosed wi...
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#1C.H. StorchH-Index: 1
#2Peter H. Hoeger (Boston Children's Hospital)H-Index: 25
Summary Infantile haemangiomas (IH) are the most common benign tumours of infancy. Although most IH are innocuous and 85–90% regress spontaneously, some may become life- or function-threatening and require immediate treatment. Previous standard therapeutic options include physical measures (laser surgery, cryosurgery) and systemic corticosteroids, in severe cases also vincristine, α-interferon or cyclophosphamide, all bearing the risk of serious side-effects. Oral propranolol is a very recent th...
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