Hajime Hosoi
Kyoto Prefectural University of Medicine
Internal medicineEndocrinologySurgeryPathologyOncologyMolecular biologyChemistryApoptosisImmunologyChemotherapyNeuroblastomaRhabdomyosarcomaTransplantationCell cycleCancer researchCell growthMedicineCell cultureBiologyGastroenterology
Publications 230
#1Akimasa Tomida (Kyoto Prefectural University of Medicine)H-Index: 1
#2Shigeki Yagyu (Kyoto Prefectural University of Medicine)H-Index: 1
Last. Tomoko Iehara (Kyoto Prefectural University of Medicine)H-Index: 21
view all 8 authors...
Disialoganglioside (GD2)-specific chimeric antigen receptor (CAR)-T cells (GD2-CAR-T cells) have been developed and tested in early clinical trials in patients with relapsed/refractory neuroblastoma. However, the effectiveness of immunotherapy using these cells is limited, and requires improvement. A combinatorial therapy with CAR-T cells and molecular targeted drugs could be a promising strategy to enhance the antitumor efficacy of CAR T-cell immunotherapy. Here, we generated GD2-CAR-T cells vi...
#1Takayo Urata (Kyoto Prefectural University of Medicine)H-Index: 1
#2Toshihiko ImamuraH-Index: 22
Last. Hajime HosoiH-Index: 33
view all 6 authors...
Fanconi anemia (FA) is a rare genetic disorder that manifests as congenital abnormalities and bone marrow failure (BMF). Most patients with FA present with BMF within the first decade of life; however, neonate and early infancy BMF is rare. Recent studies have shown that a defective aldehyde dehydrogenase 2 (ALDH2) variant accelerates BMF development in patients with FA. Herein, we described an infant case of FA with compound heterozygous FANCI mutation and the defective ALDH2 variant. Our case ...
Abstract Intraperitoneal venous malformations are uncommon; therefore, the prognosis of patients has not been determined and appropriate treatments have not been established. Here, we report a neonate with extensive intraperitoneal venous malformation. She did not have developmental disorder nor functional disability; thus, she was observed without treatment. However, the patient died suddenly of obstructive venous return disorder due to thrombosis in a vein draining from the venous malformation...
#1Kanako Noda (Kyoto Prefectural University of Medicine)
#2Shinji Akioka (Kyoto Prefectural University of Medicine)H-Index: 5
Last. Hajime Hosoi (Kyoto Prefectural University of Medicine)H-Index: 33
view all 4 authors...
Hydroxychloroquine (HCQ) is an international-standard ‘anchor’ drug for treatment of systemic lupus erythematosus (SLE). After being approved in Japan half a century later in the Western countries,...
1 CitationsSource
#1Masashi MizumotoH-Index: 28
#2Hiroshi FujiH-Index: 14
Last. Hideyuki SakuraiH-Index: 32
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Abstract Children and adolescents and young adults (AYAs) with cancer are often treated with a multidisciplinary approach. This includes use of radiotherapy, which is important for local control, but may also cause adverse events in the long term, including second cancer. The risks for limited growth and development, endocrine dysfunction, reduced fertility and second cancer in children and AYAs are reduced by proton beam therapy (PBT), which has a dose distribution that decreases irradiation of...
#1Hiroaki Kondo (Kyoto Prefectural University of Medicine)
#2Takuyo KanayamaH-Index: 2
Last. Hajime Hosoi (Kyoto Prefectural University of Medicine)H-Index: 33
view all 8 authors...
#1Satoshi Sakaue (Kyoto Prefectural University of Medicine)H-Index: 2
#2Tatsuji Hasegawa (Kyoto Prefectural University of Medicine)H-Index: 7
Last. Hajime Hosoi (Kyoto Prefectural University of Medicine)H-Index: 33
view all 9 authors...
BACKGROUND Few studies have examined the effect of low-grade intraventricular hemorrhage (IVH) on the white matter in the cerebellum and its association with neurodevelopment. We evaluated cerebellar white matter at term-equivalent age (TEA) in preterm infants with low-grade IVH. Furthermore, we assessed neurodevelopmental outcomes at three years of age to examine the influence of low-grade IVH on neurodevelopment. METHODS Thirteen infants with low-grade IVH and 26 without IVH, born at <30 weeks...
#1Hiroshi Kubo (Kyoto Prefectural University of Medicine)H-Index: 1
#2Shigeki Yagyu (Kyoto Prefectural University of Medicine)H-Index: 14
Last. Hajime Hosoi (Kyoto Prefectural University of Medicine)H-Index: 33
view all 9 authors...
Abstract Ephrin type-B receptor 4 (EPHB4), expressed in tumors including rhabdomyosarcoma, is a suitable target for chimeric antigen receptor (CAR)-T cells. Ligand independent activation of EPHB4 causes cell proliferation and malignant transformation in rhabdomyosarcoma, whereas ligand-dependent stimulation of EPHB4 induces apoptosis in rhabdomyosarcoma. Therefore, we hypothesized that ligand-based EPHB4-specific CAR-T cells may kill rhabdomyosarcoma cells without stimulating downstream cell pro...
1 CitationsSource
#1Tomoo Daifu (Kyoto University)H-Index: 2
#2Masamitsu Mikami (Kyoto University)H-Index: 4
Last. Yasuhiko Kamikubo (Kyoto University)H-Index: 14
view all 23 authors...
Malignant rhabdoid tumor (MRT) is a rare and highly aggressive pediatric malignancy primarily affecting infants and young children. Intensive multimodal therapies currently given to MRT patients are not sufficiently potent to control this highly malignant tumor. Therefore, additive or alternative therapy for these patients with a poor prognosis is necessary. We herein demonstrated that the inhibition of runt-related transcription factor 1 (RUNX1) by novel alkylating conjugated pyrrole-imidazole ...
#1Tamaki Morisako (Kyoto Prefectural University of Medicine)
#2Daisuke Umebayashi (Kyoto Prefectural University of Medicine)H-Index: 1
Last. Naoya Hashimoto (Kyoto Prefectural University of Medicine)H-Index: 30
view all 13 authors...