Tomoko Iehara
Kyoto Prefectural University of Medicine
Fusion geneCancerInternal medicineSurgeryPathologyOncologyMolecular biologyStage (cooking)PediatricsApoptosisImmunologyChemotherapyNeuroblastomaRhabdomyosarcomaCell cycleCancer researchCell growthMedicineCell cultureBiology
100Publications
21H-index
2,539Citations
Publications 100
Newest
Abstract Intraperitoneal venous malformations are uncommon; therefore, the prognosis of patients has not been determined and appropriate treatments have not been established. Here, we report a neonate with extensive intraperitoneal venous malformation. She did not have developmental disorder nor functional disability; thus, she was observed without treatment. However, the patient died suddenly of obstructive venous return disorder due to thrombosis in a vein draining from the venous malformation...
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#1Hiroshi Kubo (Kyoto Prefectural University of Medicine)H-Index: 1
#2Shigeki Yagyu (Kyoto Prefectural University of Medicine)H-Index: 14
Last. Hajime Hosoi (Kyoto Prefectural University of Medicine)H-Index: 33
view all 9 authors...
Abstract Ephrin type-B receptor 4 (EPHB4), expressed in tumors including rhabdomyosarcoma, is a suitable target for chimeric antigen receptor (CAR)-T cells. Ligand independent activation of EPHB4 causes cell proliferation and malignant transformation in rhabdomyosarcoma, whereas ligand-dependent stimulation of EPHB4 induces apoptosis in rhabdomyosarcoma. Therefore, we hypothesized that ligand-based EPHB4-specific CAR-T cells may kill rhabdomyosarcoma cells without stimulating downstream cell pro...
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#1Satoshi MiyagakiH-Index: 2
#2Ken KikuchiH-Index: 14
Last. Hajime HosoiH-Index: 33
view all 6 authors...
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#1Tomoo Daifu (Kyoto University)H-Index: 2
#2Masamitsu Mikami (Kyoto University)H-Index: 4
Last. Yasuhiko Kamikubo (Kyoto University)H-Index: 14
view all 23 authors...
Malignant rhabdoid tumor (MRT) is a rare and highly aggressive pediatric malignancy primarily affecting infants and young children. Intensive multimodal therapies currently given to MRT patients are not sufficiently potent to control this highly malignant tumor. Therefore, additive or alternative therapy for these patients with a poor prognosis is necessary. We herein demonstrated that the inhibition of runt-related transcription factor 1 (RUNX1) by novel alkylating conjugated pyrrole-imidazole ...
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#1Tomoko Iehara (Kyoto Prefectural University of Medicine)H-Index: 21
Preventing COVID-19 infection in pediatric patients with hematological disease and cancer is important. Thus, patients and those around them should avoid crowds, wear masks, and perform hand hygiene. It is necessary to try to prevent nosocomial infections during hospitalization. Moreover, determining COVID-19 complications and the condition of patients with hematological disease and cancer, and determining a personalized treatment strategy that prioritizes the treatment of high-risk conditions i...
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#1Tamaki Morisako (Kyoto Prefectural University of Medicine)
#2Daisuke Umebayashi (Kyoto Prefectural University of Medicine)H-Index: 1
Last. Naoya Hashimoto (Kyoto Prefectural University of Medicine)H-Index: 30
view all 13 authors...
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#1Takumi Yamanaka (Kyoto Prefectural University of Medicine)H-Index: 3
#2Yoshinobu Takahashi (Kyoto Prefectural University of Medicine)H-Index: 8
Last. Naoya Hashimoto (Kyoto Prefectural University of Medicine)H-Index: 30
view all 13 authors...
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#1Yasumichi Kuwahara (Kyoto Prefectural University of Medicine)H-Index: 11
#2Tomoko Iehara (Kyoto Prefectural University of Medicine)H-Index: 21
Last. Hajime Hosoi (Kyoto Prefectural University of Medicine)H-Index: 33
view all 17 authors...
Background/aim Malignant rhabdoid tumor (MRT) is a rare, aggressive neoplasm found in young children, caused by inactivation of a single gene, SNF5 (INI1, SMARCB1). MRT cases with multifocal tumors at diagnosis are categorized as synchronous MRT, often with a germline mutation of SNF5. The aim of this study was to establish new models useful in clarifying the biological basis of synchronous MRT. Materials and methods We established two novel MRT cell lines, designated as KP-MRT-KS and KP-MRT-KSa...
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#1Yohei Sugimoto (Kyoto Prefectural University of Medicine)H-Index: 1
#2Yoshiki Katsumi (Kyoto Prefectural University of Medicine)H-Index: 8
Last. Hajime Hosoi (Kyoto Prefectural University of Medicine)H-Index: 33
view all 14 authors...
Rhabdoid tumor is an aggressive, early childhood tumor. Biallelic inactivation of the SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (SMARCB1)/integrase interactor 1 (INI1) gene is the only common genetic feature in rhabdoid tumors. Loss of SMARCB1 function results in downregulation of several tumor suppressor genes including p16, p21, and NOXA. The novel histone deacetylase inhibitor, OBP-801, induces p21 and has shown efficacy against various canc...
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#1Tomoko Iehara (Kyoto Prefectural University of Medicine)H-Index: 21
#2Atsushi Manabe (Hokkaido University)H-Index: 20
Last. Hajime Hosoi (Kyoto Prefectural University of Medicine)H-Index: 33
view all 3 authors...
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